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Surgical Endoscopy

Published in:

01-01-2018

Clinical implication of endoscopic gross appearance in superficial esophageal squamous carcinoma: revisited

Authors: Cheal Wung Huh, Da Hyun Jung, Jie-Hyun Kim, Dae Won Ma, Young Hoon Youn, Hyojin Park

Published in: Surgical Endoscopy | Issue 1/2018

Abstract

Background

Standard endoscopic appearance is essential for the diagnosis and treatment of superficial esophageal squamous carcinoma (SESC). The aim of this study was to investigate the association between the endoscopic gross appearance and the clinicopathologic characteristics of SESC.

Methods

We retrospectively analyzed the clinicopathologic characteristics of SESC according to gross endoscopic appearance in 275 patients with SESC that underwent esophagectomy or endoscopic resection (ER).

Results

The proportion of type I or type III gross appearance, and that of types IIa, IIb, or IIc, were 26.2 and 73.8%, respectively. Type I or type III gross appearance was significantly associated with the female sex, submucosal invasion, lymphovascular invasion (LVI), and lymph node metastasis (LNM). In addition, younger age, larger tumor size, higher proportion of circumferential extension, type I or type III endoscopic gross appearance, submucosal invasion, moderate or poorly differentiated carcinoma, and LVI were significantly associated with LNM. Multivariate logistic regression analysis determined that independent predictors of LNM in patients with SESC included endoscopic gross appearance, submucosal invasion, and presence of LVI. Additionally, type I or type III endoscopic gross appearance lesions were more likely to have submucosal invasion than types IIa, IIb, or IIc. Risk factors for submucosal invasion included a gross appearance of type I or type III, moderately or poorly differentiated tumors, and presence of LVI.

Conclusions

We found that SESC clinical features are correlated with the endoscopic appearance. Therefore, we suggest that the endoscopic gross appearance may be a candidate for additive criteria in the indications for ER.

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Title: Clinical implication of endoscopic gross appearance in superficial esophageal squamous carcinoma: revisited
Authors: Cheal Wung Huh
Da Hyun Jung
Jie-Hyun Kim
Dae Won Ma
Young Hoon Youn
Hyojin Park
Publication date: 01-01-2018
Publisher: Springer US
Published in: Surgical Endoscopy / Issue 1/2018
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI: https://doi.org/10.1007/s00464-017-5685-8

At a glance: The STEP trials

Springer Medicine

Clinical implication of endoscopic gross appearance in superficial esophageal squamous carcinoma: revisited

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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