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01-11-2018 | Correspondence

cIMPACT-NOW update 3: recommended diagnostic criteria for “Diffuse astrocytic glioma, IDH-wildtype, with molecular features of glioblastoma, WHO grade IV”

Authors: Daniel J. Brat, Kenneth Aldape, Howard Colman, Eric C. Holland, David N. Louis, Robert B. Jenkins, B. K. Kleinschmidt-DeMasters, Arie Perry, Guido Reifenberger, Roger Stupp, Andreas von Deimling, Michael Weller

Published in: Acta Neuropathologica | Issue 5/2018

Excerpt

The World Health Organization (WHO) central nervous system tumor classification represents the primary source of updates on diagnostic classes, grades and criteria [17]. However, recent and ongoing advances in our understanding of brain tumor molecular pathogenesis warrant more rapid integration of this information into clinical practice between WHO updates. To accomplish this, cIMPACT-NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy) was established in 2016 [15, 16]. Since then, cIMPACT-NOW has convened three separate working committees to address classification and grading questions and challenges. Working Committee 1 focused on a concern that the classification and grading of Isocitrate Dehydrogenase (IDH)-wildtype diffuse astrocytic gliomas do not reflect our current understanding of the molecular pathogenesis and clinical outcomes associated with these tumors. …

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Title: cIMPACT-NOW update 3: recommended diagnostic criteria for “Diffuse astrocytic glioma, IDH-wildtype, with molecular features of glioblastoma, WHO grade IV”
Authors: Daniel J. Brat
Kenneth Aldape
Howard Colman
Eric C. Holland
David N. Louis
Robert B. Jenkins
B. K. Kleinschmidt-DeMasters
Arie Perry
Guido Reifenberger
Roger Stupp
Andreas von Deimling
Michael Weller
Publication date: 01-11-2018
Publisher: Springer Berlin Heidelberg
Published in: Acta Neuropathologica / Issue 5/2018
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-018-1913-0

At a glance: The STEP trials

Springer Medicine

cIMPACT-NOW update 3: recommended diagnostic criteria for “Diffuse astrocytic glioma, IDH-wildtype, with molecular features of glioblastoma, WHO grade IV”

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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