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01-11-2018 | Correspondence

On the origin of tau seeding activity in Alzheimer’s disease

Authors: Helmut Heinsen, Lea T. Grinberg

Published in: Acta Neuropathologica | Issue 5/2018

Excerpt

In the paper “Tau seeding activity begins in the transentorhinal (TRE)/entorhinal (EC) regions and anticipates phospho-tau pathology in Alzheimer’s disease and PART” [10] published on May 11, 2018, Kaufman and colleagues aimed to investigate the origin of tau propagation using their HEK293 cell-based bioassay to quantify tau seeding activity of four brain regions from cases at progressive AD stages. This study was based on the premise that the hierarchical spread of tau pathology in AD occurs by prion-like transcellular propagation and, thus, brain areas representing the beginning of the chain of events associated with AD-tau pathogenesis should show the earliest evidence of tau seeding. Among other assertions, the authors suggest that this study design can answer whether precortical tau accrual represented here by locus coeruleus (LC) constitute AD’s earliest stage or is merely an epiphenomenon. …

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Title: On the origin of tau seeding activity in Alzheimer’s disease
Authors: Helmut Heinsen
Lea T. Grinberg
Publication date: 01-11-2018
Publisher: Springer Berlin Heidelberg
Published in: Acta Neuropathologica / Issue 5/2018
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-018-1890-3

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