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BMC Pediatrics
Published in: BMC Pediatrics 1/2024

Open Access 01-12-2024 | Cholangiocarcinoma | Case Report

Cholangiocarcinoma identified in perforated choledochal cyst in a 3-year-old boy

Authors: Lun Yu, Wenli Xiu, Aimei Yue, Xiwei Hao, Zhong Jiang, Jie Wu, Qian Dong

Published in: BMC Pediatrics | Issue 1/2024

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Abstract

Cholangiocarcinoma in patients with Choledochal cysts is rare in childhood; however, it seriously affects the prognosis of the disease. The key to addressing this situation lies in completely removing the extrahepatic cyst. We herein present a case report of a 3-year-old boy with cholangiocarcinoma associated with a choledochal cyst (CDC). Preoperative 3D simulation, based on CT data, played an important role in the treatment of this patient.
Literature
1.
Baison GN, Bonds MM, Helton WS, et al. Choledochal cysts: similarities and differences between Asian and western countries. World J Gastroenterol. 2019;25:3334–43.CrossRefPubMedPubMedCentral
2.
Soares KC, Goldstein SD, Ghaseb MA, et al. Pediatric choledochal cysts: diagnosis and current management. PEDIATR SURG INT. 2017;33:637–50.CrossRefPubMed
3.
4.
Ohba G, Yamamoto H, Nakayama M, et al. Single-stage operation for perforated choledochal cyst. J PEDIATR SURG. 2018;53:653–5.CrossRefPubMed
5.
Madadi-Sanjani O, Wirth TC, Kuebler JF, et al. Choledochal Cyst and Malignancy: a Plea for lifelong Follow-Up. EUR J PEDIATR SURG. 2019;29:143–9.CrossRefPubMed
6.
Iwai N, Deguchi E, Yanagihara J, et al. Cancer arising in a choledochal cyst in a 12-year-old girl. J PEDIATR SURG. 1990;25:1261–3.CrossRefPubMed
7.
Tanaka S, Kubota M, Yagi M, et al. An 11-year-old male patient demonstrating cholangiocarcinoma associated with congenital biliary dilatation. J PEDIATR SURG. 2006;41:e15–9.CrossRefPubMed
8.
Saikusa N, Naito S, Iinuma Y, et al. Invasive cholangiocarcinoma identified in congenital biliary dilatation in a 3-year-old boy. J PEDIATR SURG. 2009;44:2202–5.CrossRefPubMed
9.
Chiang L, Chui CH, Low Y, et al. Perforation: a rare complication of choledochal cysts in children. PEDIATR SURG INT. 2011;27:823–7.CrossRefPubMed
10.
Lee MJ, Kim MJ, Yoon CS. MR cholangiopancreatography findings in children with spontaneous bile duct perforation. PEDIATR RADIOL. 2010;40:687–92.CrossRefPubMed
11.
Kasai Y, Aoki R, Nagano N, et al. Usefulness of thin-slice contrast-enhanced computed Tomography in detecting perforation site in congenital biliary dilatation: a Case Report. J NIPPON MED SCH. 2023;89:623–8.CrossRefPubMed
12.
Chen W, Zhao L, Wang J, et al. Hepatic vascular variations and visual three-dimensional reconstruction technique in pediatric patients with choledochal cyst. SURG RADIOL ANAT. 2020;42:1489–99.CrossRefPubMed
13.
Li X, Duan R, He Y, et al. Application of three-dimensional visualization technology in the anatomical variations of hilar bile ducts in Chinese population. Front Surg. 2022;9:934183.CrossRefPubMedPubMedCentral
14.
Zhao J, Zhou XJ, Zhu CZ, et al. 3D simulation assisted resection of giant hepatic mesenchymal hamartoma in children. Comput Assist Surg (Abingdon). 2017;22:54–9.CrossRefPubMed
15.
Xiu W, Liu J, Li T, et al. Application value of computer-assisted surgery system in pediatric hepatic hemangioma. PEDIATR SURG INT. 2021;37:1575–83.CrossRefPubMed
16.
Liu Y, Xia N, Duan Y, et al. Application of computer-assisted surgery in pediatric mediastinal tumor surgery. Int J Med Robot. 2023;19:e2489.CrossRefPubMed
17.
Ishibashi H, Shimada M, Kamisawa T, et al. Japanese clinical practice guidelines for congenital biliary dilatation. J Hepatobiliary Pancreat Sci. 2017;24:1–16.CrossRefPubMed
18.
Kamisawa T, Ando H, Suyama M, et al. Japanese clinical practice guidelines for pancreaticobiliary maljunction. J GASTROENTEROL. 2012;47:731–59.CrossRefPubMed
19.
Tsuchida A, Itoi T, Aoki T, et al. Carcinogenetic process in gallbladder mucosa with pancreaticobiliary maljunction (review). ONCOL REP. 2003;10:1693–9.PubMed
20.
Mori H, Masahata K, Umeda S, et al. Risk of carcinogenesis in the biliary epithelium of children with congenital biliary dilatation through epigenetic and genetic regulation. SURG TODAY. 2022;52:215–23.CrossRefPubMed
21.
Ono S, Tokiwa K, Iwai N. Cellular activity in the gallbladder of children with anomalous arrangement of the pancreaticobiliary duct. J PEDIATR SURG. 1999;34:962–6.CrossRefPubMed
22.
Gao R, Ke M, Shi J, et al. Establishment and validation of a predictive nomogram for the risk of premalignant lesions in children with choledochal cyst. FRONT PEDIATR. 2023;11:1108788.CrossRefPubMedPubMedCentral
23.
Sastry AV, Abbadessa B, Wayne MG, et al. What is the incidence of biliary carcinoma in choledochal cysts, when do they develop, and how should it affect management? WORLD J SURG. 2015;39:487–92.CrossRefPubMed
24.
Xia HT, Yang T, Liang B, et al. Treatment and outcomes of adults with remnant intrapancreatic choledochal cysts. SURGERY. 2016;159:418–25.CrossRefPubMed
25.
Chun YS, Pawlik TM, Vauthey JN. 8th Edition of the AJCC Cancer staging Manual: pancreas and hepatobiliary cancers. ANN SURG ONCOL. 2018;25:845–7.CrossRefPubMed
26.
Iwano K, Kurita A, Yazumi S. Carcinoma in situ of the perihilar bile duct diagnosed by peroral cholangioscopy. J Hepatobiliary Pancreat Sci. 2022;29:e84–5.CrossRefPubMed
27.
Hong SM, Pawlik TM, Cho H, et al. Depth of tumor invasion better predicts prognosis than the current American Joint Committee on Cancer T classification for distal bile duct carcinoma. SURGERY. 2009;146:250–7.CrossRefPubMed
28.
Nakanishi Y, Zen Y, Kawakami H, et al. Extrahepatic bile duct carcinoma with extensive intraepithelial spread: a clinicopathological study of 21 cases. Mod Pathol. 2008;21:807–16.CrossRefPubMed
Metadata
Title
Cholangiocarcinoma identified in perforated choledochal cyst in a 3-year-old boy
Authors
Lun Yu
Wenli Xiu
Aimei Yue
Xiwei Hao
Zhong Jiang
Jie Wu
Qian Dong
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Pediatrics / Issue 1/2024
Electronic ISSN: 1471-2431
DOI
https://doi.org/10.1186/s12887-024-04709-y

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