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BMC Pediatrics

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Open Access 01-12-2024 | Acute Kidney Injury | Research

Sustained acute kidney injury as an independent risk factor for neurodevelopmental and growth outcomes in a single NICU center

Authors: Chen-Wei Yen, Ming-Chou Chiang, Shih-Ming Chu, Hsiao-Chin Wang, Li-Chun Wu, Po-Cheng Yen, Mei-Ching Yu

Published in: BMC Pediatrics | Issue 1/2024

Abstract

Purpose

Acute kidney injury (AKI) is commonly seen in neonatal intensive care units (NICUs) and is potentially associated with adverse prognoses in later stages of life. Our study evaluated the impact of sustained AKI (SAKI) on both neurodevelopmental impairment (NDI) and early growth restriction (EGR) in neonates.

Methods

This case-control study retrospectively analyzed the medical records of neonates diagnosed with SAKI in the NICU of a tertiary medical center during the period from January 2007 to December 2020. Cases without subsequent follow-up and those resulting in death were excluded. We analyzed demographic, biochemical, and clinical outcome data.

Results

Of the 93 neonates with SAKI, 51 cases (54.8%) were included in this study, while 42 cases (45.2%) were excluded due to a lack of follow-up or death. An age-matched control group comprised 103 neonates, who had never experienced AKI or SAKI, were selected at random. In total, 59 (38.3%) cases were identified as NDI and 43 (27.9%) as EGR. Multivariate analysis revealed that patients with SAKI had significantly higher risks of developing NDI (odds ratio, [OR] = 4.013, p = 0.001) and EGR (OR = 4.894, p < 0.001). The AKI interval had an area under the receiver operating characteristic curve of 0.754 for NDI at 9.5 days and 0.772 for EGR at 12.5 days.

Conclusions

SAKI is an independent risk factor for both NDI and EGR in neonates. Consequently, regular monitoring, neurological development assessments, and appropriate nutritional advice are crucial to these infants who have experienced renal injury.

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Title: Sustained acute kidney injury as an independent risk factor for neurodevelopmental and growth outcomes in a single NICU center
Authors: Chen-Wei Yen
Ming-Chou Chiang
Shih-Ming Chu
Hsiao-Chin Wang
Li-Chun Wu
Po-Cheng Yen
Mei-Ching Yu
Publication date: 01-12-2024
Publisher: BioMed Central
Keywords: Acute Kidney Injury
Acute Kidney Injury
Published in: BMC Pediatrics / Issue 1/2024
Electronic ISSN: 1471-2431
DOI: https://doi.org/10.1186/s12887-024-04568-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Sustained acute kidney injury as an independent risk factor for neurodevelopmental and growth outcomes in a single NICU center

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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