Published in:
01-02-2021 | Cholangiocarcinoma | Case Report
A case of mixed neuroendocrine non-neuroendocrine neoplasm of the distal bile duct with biliary intraepithelial neoplasia
Authors:
Miyuki Kaino, Seiji Kaino, Wakana Goma, Eizaburo Hideura, Tomoki Hitosugi, Yohei Harima, Yohei Urata, Yohei Nakamura
Published in:
Clinical Journal of Gastroenterology
|
Issue 1/2021
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Abstract
A 72-year-old man with obstructive jaundice, diagnosed with distal biliary carcinoma, underwent pylorus-preserving pancreaticoduodenectomy. The patient was histopathologically and immunohistochemically diagnosed with mixed neuroendocrine non-neuroendocrine neoplasm. Pathological examination revealed that the well-differentiated adenocarcinoma components occupied the superficial portion of the bile duct and the neuroendocrine carcinoma components were located in the deeper portion of the bile duct. Pathological examination showed that a portion of the biliary intraepithelial neoplasia arose from the proximal bile duct and then extended to the gallbladder. The patient was administered tegafur/gimeracil/oteracil as adjuvant chemotherapy, and the lesion did not recur for 6 months postoperatively.