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Journal of Gastroenterology
Published in: Journal of Gastroenterology 1/2014

01-01-2014 | Review

Pathological diagnosis of flat epithelial lesions of the biliary tract with emphasis on biliary intraepithelial neoplasia

Authors: Yasunori Sato, Motoko Sasaki, Kenichi Harada, Shinichi Aishima, Toshio Fukusato, Hidenori Ojima, Yae Kanai, Masayoshi Kage, Yasuni Nakanuma, Hirohito Tsubouchi, Hepatolithiasis Subdivision of Intractable Hepatobiliary Diseases Study Group of Japan (Chairman, Hirohito Tsubouchi)

Published in: Journal of Gastroenterology | Issue 1/2014

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Abstract

Flat epithelial lesions of the biliary tract cannot be detected by the image analysis, and the diagnosis entirely depends on pathological examination. The biliary tract is often affected by inflammatory conditions, and the resultant changes of the biliary epithelium make it difficult to differentiate them from neoplasia. Thus, the pathological diagnosis of biliary flat epithelial lesions can be challenging. In the biliary tract, there are several forms of intraepithelial neoplasia of the flat type, and biliary intraepithelial neoplasia (BilIN) is known as one of such lesions that represent the multistep cholangiocarcinogenesis. In this article, the diagnostic criteria and the differential diagnosis of biliary flat epithelial lesions, particularly focusing on BilIN, were presented and discussed to provide help to advance clinical and research applications of the BilIN system.
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Metadata
Title
Pathological diagnosis of flat epithelial lesions of the biliary tract with emphasis on biliary intraepithelial neoplasia
Authors
Yasunori Sato
Motoko Sasaki
Kenichi Harada
Shinichi Aishima
Toshio Fukusato
Hidenori Ojima
Yae Kanai
Masayoshi Kage
Yasuni Nakanuma
Hirohito Tsubouchi
Hepatolithiasis Subdivision of Intractable Hepatobiliary Diseases Study Group of Japan (Chairman, Hirohito Tsubouchi)
Publication date
01-01-2014
Publisher
Springer Japan
Published in
Journal of Gastroenterology / Issue 1/2014
Print ISSN: 0944-1174
Electronic ISSN: 1435-5922
DOI
https://doi.org/10.1007/s00535-013-0810-5

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