Published in:
01-06-2010 | Gastrointestinal Oncology
Chemoradiotherapy in Adenocarcinoma of the Stomach or Esophagus
Authors:
Christof Hottenrott, MD, Dimosthenis Ziogas, MD
Published in:
Annals of Surgical Oncology
|
Issue 6/2010
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Excerpt
Adjuvant postoperative chemoradiotherapy has been the standard of care for adenocarcinoma of the stomach and esophagogastric junction in the United States. This recommendation is based on the positive results of a phase III randomized controlled trial (INT-0116). However, the extent of surgery with limited D0 or D1 lymphadenectomy in this study has been criticized. This treatment modality has not been adopted as standard approach in Japan and Europe. It is though that better locoregional tumor control and improved distant recurrence can be achieved with D2 surgery and postoperative adjuvant chemotherapy or surgery plus perioperative chemotherapy. …