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Intensive Care Medicine

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01-03-2005 | Original

Cerebro-pulmonary interactions during the application of low levels of positive end-expiratory pressure

Authors: Luciana Mascia, Salvatore Grasso, Tommaso Fiore, Francesco Bruno, Maurizio Berardino, Alessandro Ducati

Published in: Intensive Care Medicine | Issue 3/2005

Abstract

Objective

In patients with severe brain injury and acute lung injury the use of positive end-expiratory pressure (PEEP) is limited by conflicting results on its effect on intracranial pressure. We hypothesised that the occurrence of alveolar hyperinflation during the application of PEEP would lead to an increase in PaCO₂ responsible for a rise in intracranial pressure.

Design

Prospective interventional study.

Setting

Intensive Care Unit of University Hospitals.

Patients and participants

Twelve severely brain-injured patients with acute lung injury and intracranial pressure higher than applied PEEP.

Interventions

5 and 10 cmH₂O of PEEP was randomly applied.

Measurements and results

In all patients intracranial pressure, flow velocity by transcranial Doppler of middle cerebral artery, and jugular oxygen saturation were recorded. Static volume-pressure curves of the respiratory system were obtained, recruited volume and elastance calculated to classify patients as recruiters and non-recruiters. In recruiters (= 6 patients), elastance decreased (P<0.01) and PaO₂ increased (P<0.005), while in non-recruiters (= 6 patients) elastance and PaCO₂ significantly increased (P<0.001). Intracranial pressure, Doppler flow velocity, and jugular saturation remained constant in recruiters but significantly increased (P<0.0001) in non-recruiters. A significant correlation was found between changes in intracranial pressure and elastance (r² = 0.8 P<0.0001) and between changes in PaCO₂ and intracranial pressure (P<0.001, r² = 0.4) and elastance (P<0.001, r² = 0.4), respectively.

Conclusions

When PEEP induced alveolar hyperinflation leading to a significant increase in PaCO₂, intracranial pressure significantly increased, whereas when PEEP caused alveolar recruitment intracranial pressure did not change.

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Title: Cerebro-pulmonary interactions during the application of low levels of positive end-expiratory pressure
Authors: Luciana Mascia
Salvatore Grasso
Tommaso Fiore
Francesco Bruno
Maurizio Berardino
Alessandro Ducati
Publication date: 01-03-2005
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 3/2005
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-004-2491-2

At a glance: The STEP trials

Springer Medicine

Cerebro-pulmonary interactions during the application of low levels of positive end-expiratory pressure

Abstract

Objective

Design

Setting

Patients and participants

Interventions

Measurements and results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Design

Setting

Patients and participants

Interventions

Measurements and results

Conclusions

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