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Intensive Care Medicine

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01-03-2005 | Experimental

Breath-to-breath analysis of abdominal and rib cage motion in surfactant-depleted piglets during high-frequency oscillatory ventilation

Authors: Dick G. Markhorst, Jos R. C. Jansen, Adrianus J. van Vught, Huibert R. van Genderingen

Published in: Intensive Care Medicine | Issue 3/2005

Abstract

Objective

To assess the value of monitoring abdominal and rib cage tidal displacement as an indicator of optimal mean airway pressure (Paw) during high-frequency oscillatory ventilation (HFOV).

Design and setting

Prospective observational study in a university research laboratory.

Animals

Eight piglets weighing 12.0±0.5 kg, surfactant depleted by lung lavage.

Interventions

Compliance of the respiratory system (C_rs) was calculated from a quasistatic pressure volume loop. After initiation of HFOV lung volume was recruited by increasing Paw to 40 cmH₂O. Then mean Paw was decreased in steps until PaO₂/FIO₂ was below 100 mmHg. Proximal pressure amplitude remained constant.

Measurements and results

Abdominal and rib cage tidal displacement was determined using respiratory inductive plethysmography. During HFOV there was maximum in tidal volume (Vt) in seven of eight piglets. At maximal mean Paw abdominal and rib cage displacement were in phase. Phase difference between abdominal and rib cage displacement increased to a maximum of 178±28° at minimum mean Paw. A minimum in abdominal displacement and a maximum of Vt was found near the optimal mean Paw, defined as the lowest mean Paw where shunt fraction is below 0.1.

Conclusions

During HFOV abdominal and rib cage displacement displayed mean Paw dependent asynchrony. Maximal Vt and minimal abdominal displacement coincided with optimal C_rs, oxygenation, and ventilation, suggesting potential clinical relevance of monitoring Vt and abdominal displacement during HFOV.

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Title: Breath-to-breath analysis of abdominal and rib cage motion in surfactant-depleted piglets during high-frequency oscillatory ventilation
Authors: Dick G. Markhorst
Jos R. C. Jansen
Adrianus J. van Vught
Huibert R. van Genderingen
Publication date: 01-03-2005
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 3/2005
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-004-2535-7

2024 ASCO Annual Meeting

Springer Medicine

Breath-to-breath analysis of abdominal and rib cage motion in surfactant-depleted piglets during high-frequency oscillatory ventilation

Abstract

Objective

Design and setting

Animals

Interventions

Measurements and results

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Objective

Design and setting

Animals

Interventions

Measurements and results

Conclusions

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