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Molecular Diagnosis & Therapy
Published in: Molecular Diagnosis & Therapy 3/2008

01-05-2008 | CNS Disorders

Cerebral Small Vessel Disease

Genetic Risk Assessment for Prevention and Treatment

Authors: Ada Lam, M. Anne Hamilton-Bruce, Jim Jannes, Dr Simon A. Koblar

Published in: Molecular Diagnosis & Therapy | Issue 3/2008

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Abstract

Cerebrovascular disease is a major burden to individuals and their communities worldwide. Stroke is one of the leading causes of death and disability, and the prevention and treatment of stroke can be improved with a better understanding of its causation. Cerebral small vessel disease (SVD) is a subset of cerebrovascular disease, and has an equally large impact on an individual’s quality of life. Although many risk factors are involved, we propose that genetics has a significant role in the pathogenesis of SVD through a complex interplay of environmental and multigenetic factors. Advances in molecular technology have enabled the human genome to be investigated both at a population and, more recently, an individual level. A better understanding of the molecular basis of SVD will enable the development of therapies to help in its prevention and treatment. This review assesses the molecular genetics underlying cerebral SVD.
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Metadata
Title
Cerebral Small Vessel Disease
Genetic Risk Assessment for Prevention and Treatment
Authors
Ada Lam
M. Anne Hamilton-Bruce
Jim Jannes
Dr Simon A. Koblar
Publication date
01-05-2008
Publisher
Springer International Publishing
Published in
Molecular Diagnosis & Therapy / Issue 3/2008
Print ISSN: 1177-1062
Electronic ISSN: 1179-2000
DOI
https://doi.org/10.1007/BF03256279

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