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01-08-2016 | Original Article

Cerebral blood flow and metabolism associated with cerebral microbleeds in small vessel disease

Authors: Tetsuya Hashimoto, Chiaki Yokota, Kazuhiro Koshino, Ryo Shimomura, Tenyu Hino, Tetsuaki Moriguchi, Yuki Hori, Toshiyuki Uehara, Kazuo Minematsu, Hidehiro Iida, Kazunori Toyoda

Published in: Annals of Nuclear Medicine | Issue 7/2016

Abstract

Objective

Cerebral microbleeds (CMBs), probably reflecting microangiopathy, have not yet sufficiently been examined in association with cerebral blood flow (CBF) and metabolism. We investigated the relationships between CMBs, and CBF and metabolism in symptomatic small vessel disease.

Methods

We enrolled 22 patients with symptomatic small vessel disease without severe stenosis (>50 %) in major cerebral arteries. Volumes of white matter lesions (WMLs) and number of CMBs were assessed on images of fluid-attenuated inversion recovery and gradient-echo T2*-weighted magnetic resonance imaging, respectively. Patients were divided into two groups according to the median number of CMBs (group I <5, n = 10; group II ≥5, n = 12). Parametric images of CBF, cerebral metabolic rate of oxygen (CMRO₂), oxygen extraction fraction and cerebral blood volume were estimated using positron emission tomography and ¹⁵O-labeled gases. The functional values in the cortex–subcortex, basal ganglia, and centrum semiovale were compared between the two groups.

Results

Volumes of WMLs of group II were larger than those of group I (median: 38.4; range: 25.1–91.5 mL vs. median: 11.3; range: 4.2–73.4 mL, p = 0.01). In the centrum semiovale, the mean CBF of group II was significantly lower than that of group I (12.6 ± 2.6 vs. 15.6 ± 3.3 mL/100 g/min, p = 0.04). In the other regions, there were no significant differences in either CBF or CMRO₂ between the two groups.

Conclusions

Our study indicated that increases in the number of CMBs with larger volumes of WMLs were associated with cerebral ischemia in the deep white matter in patients with symptomatic small vessel disease.

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Title: Cerebral blood flow and metabolism associated with cerebral microbleeds in small vessel disease
Authors: Tetsuya Hashimoto
Chiaki Yokota
Kazuhiro Koshino
Ryo Shimomura
Tenyu Hino
Tetsuaki Moriguchi
Yuki Hori
Toshiyuki Uehara
Kazuo Minematsu
Hidehiro Iida
Kazunori Toyoda
Publication date: 01-08-2016
Publisher: Springer Japan
Published in: Annals of Nuclear Medicine / Issue 7/2016
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-016-1086-7

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Springer Medicine

Cerebral blood flow and metabolism associated with cerebral microbleeds in small vessel disease

Abstract

Objective

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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