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BMC Immunology
Published in: BMC Immunology 1/2021

Open Access 01-12-2021 | Central Nervous System Trauma | Research article

Anti-inflammatory protein TNFα-stimulated gene-6 (TSG-6) reduces inflammatory response after brain injury in mice

Authors: Kazadi Nadine Mutoji, Mingxia Sun, Amanda Nash, Sudan Puri, Vincent Hascall, Vivien J. Coulson-Thomas

Published in: BMC Immunology | Issue 1/2021

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Abstract

Background

Current research suggests that the glial scar surrounding penetrating brain injuries is instrumental in preserving the surrounding uninjured tissue by limiting the inflammatory response to the injury site. We recently showed that tumor necrosis factor (TNF)-stimulated gene-6 (TSG-6), a well-established anti-inflammatory molecule, is present within the glial scar. In the present study we investigated the role of TSG-6 within the glial scar using TSG-6 null and littermate control mice subjected to penetrating brain injuries.

Results

Our findings show that mice lacking TSG-6 present a more severe inflammatory response after injury, which was correlated with an enlarged area of astrogliosis beyond the injury site.

Conclusion

Our data provides evidence that TSG-6 has an anti-inflammatory role within the glial scar.
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Metadata
Title
Anti-inflammatory protein TNFα-stimulated gene-6 (TSG-6) reduces inflammatory response after brain injury in mice
Authors
Kazadi Nadine Mutoji
Mingxia Sun
Amanda Nash
Sudan Puri
Vincent Hascall
Vivien J. Coulson-Thomas
Publication date
01-12-2021
Publisher
BioMed Central
Published in
BMC Immunology / Issue 1/2021
Electronic ISSN: 1471-2172
DOI
https://doi.org/10.1186/s12865-021-00443-7

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