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European Archives of Paediatric Dentistry

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11-03-2023 | Caries | Original Scientific Article

Dental caries and dental developmental defects as adverse effects of antineoplastic treatment in childhood cancer survivors

Authors: K. Seremidi, K. Kavvadia, A. Kattamis, A. Polychronopoulou

Published in: European Archives of Paediatric Dentistry | Issue 3/2023

Abstract

Purpose

To evaluate the prevalence of dental caries and dental developmental defects (DDD) in childhood cancer survivors (CCS) and identify disease and treatment-related risk factors.

Methods

CCS aged up to 21 years, diagnosed with a malignancy before the age of 10 years and in remission for at least one year were included. Data were collected from patients’ medical records and through a clinical examination where presence of dental caries and prevalence of DDD were recorded. Fisher’s exact test was used to assess possible correlations and multivariate regression analysis to determine risk factors for defect development.

Results

Seventy CCS with a mean chronological age of 11.2 years at the time of examination, mean age at cancer diagnosis of 4.17 years, and a mean post-treatment follow-up time of 5.48 years were included. Mean DMFT/dmft was 1.31, with 29% of survivors presenting with at least one carious lesion. Younger patients on the day of examination and patients treated with higher radiation dose, showed significantly higher prevalence of dental caries. The prevalence of DDD was 59%, with demarcated opacities being the defect most commonly observed (40%). Age at dental examination, diagnosis, age at diagnosis, and time that have elapsed since the end of treatment were the factors significantly affecting its prevalence. Regression analysis revealed that age at examination was the only factor significantly associated with the presence of coronal defects.

Conclusion

A great number of CCS presented with at least one carious lesion or a DDD, with the prevalence being significantly associated with various disease-specific characteristics, but age at dental examination the only significant predictor.

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Title: Dental caries and dental developmental defects as adverse effects of antineoplastic treatment in childhood cancer survivors
Authors: K. Seremidi
K. Kavvadia
A. Kattamis
A. Polychronopoulou
Publication date: 11-03-2023
Publisher: Springer Berlin Heidelberg
Keyword: Caries
Published in: European Archives of Paediatric Dentistry / Issue 3/2023
Print ISSN: 1818-6300
Electronic ISSN: 1996-9805
DOI: https://doi.org/10.1007/s40368-023-00789-z

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Springer Medicine

Dental caries and dental developmental defects as adverse effects of antineoplastic treatment in childhood cancer survivors

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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