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BMC Oral Health
Published in: BMC Oral Health 1/2023

Open Access 01-12-2023 | Caries | Research

Associations between missing teeth and the risk of cancer in Korea: a nationwide cohort study

Authors: Eun Joo Kang, Seok-joo Moon, Kyoungmin Lee, In Hae Park, Jung Sun Kim, Yoon Ji Choi

Published in: BMC Oral Health | Issue 1/2023

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Abstract

Background

Poor dental health is correlated with an increased risk of cancer. Using a nationwide population cohort database, we investigated which cancer is highly associated with poor dental health and which dental indicator mostly influences cancer risk.

Methods

This study was conducted using the National Health Checkups (NHC) and National Health Insurance System (NHIS) database in Korea. NHC in Korea includes dental examinations. We retrieved subjects who underwent NHC between 2002 and 2003 and their medical information in NHIS database was followed until December 31,2015.

Results

Data for 200,170 who participated in the NHC between 2002 and 2003 were analysed. During the maximum follow-up period of 13 years, 15,506 (7.75%) subjects were diagnosed with cancer. The median time to cancer diagnosis after the dental examination was 87 months (range, 51–119 months). The proportion of people with missing teeth was higher in the cancer-diagnosed group than in the non-diagnosed group (26.27% vs. 22.59%, p < 0.001). Among several dental health factors, missing teeth were significantly associated with higher cancer risk. Subjects with missing teeth showed a 12% increased cancer risk compared to those without missing teeth (odds ratio [OR] 1.12, 95% confidence interval [CI], 1.08–1.16). The risk was significantly higher, especially in lung, head and neck, pancreatic, liver, biliary, and esophageal cancers (OR 1.27 [95% CI, 1.14–1.41], 1.32 [95% CI, 1.13–1.55], 1.27 [95% CI, 1.02–1.58], 1.24 [95% CI, 1.1–1.4], 1.28 [95% CI, 1.03–1.6], 1.4 [95% CI, 1.04–1.88], respectively).

Conclusions

Missing teeth were the most important dental indicator associated with cancer risk. Korean adults with missing teeth should be cautious about the risk of several cancers, particularly head and neck, lung, gastrointestinal, hepatobiliary, and pancreatic cancer.
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Metadata
Title
Associations between missing teeth and the risk of cancer in Korea: a nationwide cohort study
Authors
Eun Joo Kang
Seok-joo Moon
Kyoungmin Lee
In Hae Park
Jung Sun Kim
Yoon Ji Choi
Publication date
01-12-2023
Publisher
BioMed Central
Keyword
Caries
Published in
BMC Oral Health / Issue 1/2023
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-023-02997-x

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