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Journal of Nuclear Cardiology
Published in: Journal of Nuclear Cardiology 4/2023

07-06-2022 | Cardiomyopathy | Images that Teach

High-resolution PET demonstrates extensive ischemia/fibrosis mismatch in a patient with hypertrophic cardiomyopathy: the power of multimodality image fusion

Authors: A. M. Crean, G. S. Small, B. J. W. Chow, T. D. Ruddy, R. S. B. Beanlands, R. A. deKemp

Published in: Journal of Nuclear Cardiology | Issue 4/2023

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Excerpt

Chest pain is common in patients with hypertrophic cardiomyopathy (HCM)1, although it is very often not due to epicardial coronary disease2. Both outflow tract obstruction and microvascular dysfunction have been suggested as potential mechanisms of angina. Small intramural coronary artery dysplasia (SICAD) is ubiquitous in this condition3, and repetitive microvascular ischemia could be a promoter of interstitial fibrosis—which is present in almost three quarters of HCM patients to varying degrees. …
Literature
1.
Elliott PM, Kaski JC, Prasad K, Seo H, Slade AK, Goldman JH. Chest pain during daily life in patients with hypertrophic cardiomyopathy: An ambulatory electrocardiographic study. Eur Heart J 1996;17:1056-64.CrossRefPubMed
2.
Shariat M, Thavendiranathan P, Nguyen E, Wintersperger B, Paul N, Rakowski H, et al. Utility of coronary CT angiography in outpatients with hypertrophic cardiomyopathy presenting with angina symptoms. J Cardiovasc Comput Tomogr 2014;8:429-37.CrossRefPubMed
3.
Johansson B, Mörner S, Waldenström A, Stål P. Myocardial capillary supply is limited in hypertrophic cardiomyopathy: A morphological analysis. Int J Cardiol 2008;126:252-7.CrossRefPubMed
4.
Johnson NP, Gould KL. Integrating noninvasive absolute flow, coronary flow reserve, and ischemic thresholds into a comprehensive map of physiological severity. JACC Cardiovasc Imaging 2012;5:430-40.CrossRefPubMed
Metadata
Title
High-resolution PET demonstrates extensive ischemia/fibrosis mismatch in a patient with hypertrophic cardiomyopathy: the power of multimodality image fusion
Authors
A. M. Crean
G. S. Small
B. J. W. Chow
T. D. Ruddy
R. S. B. Beanlands
R. A. deKemp
Publication date
07-06-2022
Publisher
Springer International Publishing
Published in
Journal of Nuclear Cardiology / Issue 4/2023
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI
https://doi.org/10.1007/s12350-022-02993-8

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