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Journal of Gastrointestinal Cancer
Published in: Journal of Gastrointestinal Cancer 3/2020

01-09-2020 | Cancer Therapy | Review Article

Anticancer Effects of Herbal Medicine Compounds and Novel Formulations: a Literature Review

Authors: Manal Khalid Abdulridha, Ali H. Al-Marzoqi, Ghaidaa Raheem Lateef Al-awsi, Shaden M. H. Mubarak, Maryam Heidarifard, Abdolmajid Ghasemian

Published in: Journal of Gastrointestinal Cancer | Issue 3/2020

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Abstract

Introduction

Many agents disrupt the cell cycle and its signaling circuits leading to cancer progress. Cancer therapy is performed by surgery, radiation, and chemical drugs remaining some side effects.

Objective

To evaluate the anticancer traits of herbal medicines.

Methods

We collected previously published data in searching engines (Web of Science, PubMed, Medline, and SCOPUS) by searching key words “herbal medicine,” “anticancer effect,” “compounds,” and “fractions.”

Results

Herbal medicines have unraveled anticancer effects mostly through cancer cells apoptosis via blocking NF-κB pathway by curcumin and terpenoides; CD95 signaling and enhancement of CD95L expression by resveratrol; and inhibiting tyrosine kinas, angiogenesis, and cell cycle arrest in G2/M phase by β-lapachone-genistein and cytochrome-c release into the cytosol and caspase-9 activation by biocalein and quercetin. Additionally, impeding cell cycle in the G1 phase in ovarian cancer cells by 7-hydroxystaurosporine, immune cells enrichment (neutrophils and NK cells activation by Viscum album L., T cells and NK cells activation and cytokines such as tumor necrosis factor release by Ganoderma lucidum and microRNAs regulation (by Sinomeniumacutum, shikonin, Oleaeuropaea, curcumin and ginseng). These effects have implications for proper cancer cells elimination. It has been revealed that cytotoxic effects of herbal compounds (mostly those secondary metabolites) have exerted anticancer properties against several cancer cell lines. In addition, targeting microRNAs, nanoparticle-assisted herbal synergism, and novel drug delivery systems and combination chemotherapies have also emerged exerting higher efficacies for specific cell targeting as novel cancer therapy approaches.

Conclusion

Considering side effects, toxicity, and higher costs of common cancer therapy approaches, application of novel herbal medicine-based therapies will confer promising insights for health outcomes.
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Metadata
Title
Anticancer Effects of Herbal Medicine Compounds and Novel Formulations: a Literature Review
Authors
Manal Khalid Abdulridha
Ali H. Al-Marzoqi
Ghaidaa Raheem Lateef Al-awsi
Shaden M. H. Mubarak
Maryam Heidarifard
Abdolmajid Ghasemian
Publication date
01-09-2020
Publisher
Springer US
Keyword
Cancer Therapy
Published in
Journal of Gastrointestinal Cancer / Issue 3/2020
Print ISSN: 1941-6628
Electronic ISSN: 1941-6636
DOI
https://doi.org/10.1007/s12029-020-00385-0

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