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Cancer Immunology, Immunotherapy

Issue 3/2023

Content (22 Articles)

Open Access Acute Myeloid Leukemia Original Article

Invariant NKT cells metabolically adapt to the acute myeloid leukaemia environment

Victoria Stavrou, Livingstone Fultang, Sarah Booth, Daniele De Simone, Arekdiusz Bartnik, Ugo Scarpa, Luciana Gneo, Silvia Panetti, Sandeep Potluri, Meaad Almowaled, Jonathan Barlow, Andris Jankevics, Gavin Lloyd, Andrew Southam, David A. Priestman, Paul Cheng, Warwick Dunn, Frances Platt, Hitoshi Endou, Charles Craddock, Karen Keeshan, Francis Mussai, Carmela De Santo

SCLC Original Article

Protein Expression of immune checkpoints STING and MHCII in small cell lung cancer

David Dora, Christopher Rivard, Hui Yu, Shivaun Lueke Pickard, Viktoria Laszlo, Tunde Harko, Zsolt Megyesfalvi, Csongor Gerdan, Elek Dinya, Konrad Hoetzenecker, Fred R. Hirsch, Zoltan Lohinai, Balazs Dome

NSCLC Original Article

Interplay between plasmacytoid dendritic cells and tumor-specific T cells in peripheral blood influences long-term survival in non-small cell lung carcinoma

Caroline Laheurte, Evan Seffar, Eléonore Gravelin, Julie Lecuelle, Adeline Renaudin, Laura Boullerot, Marine Malfroy, Amélie Marguier, Benoit Lecoester, Béatrice Gaugler, Philippe Saas, Caroline Truntzer, Francois Ghiringhelli, Olivier Adotevi

Melanoma Original Article

Machine learning algorithm-generated and multi-center validated melanoma prognostic signature with inspiration for treatment management

Zaoqu Liu, Hui Xu, Siyuan Weng, Chunguang Guo, Qin Dang, Yuyuan Zhang, Yuqing Ren, Long Liu, Libo Wang, Xiaoyong Ge, Zhe Xing, Jian Zhang, Peng Luo, Xinwei Han

Open Access Lung Cancer Original Article

Costimulatory molecule expression profile as a biomarker to predict prognosis and chemotherapy response for patients with small cell lung cancer

Peng Wu, Zhihui Zhang, Zhaoyang Yang, Chaoqi Zhang, Yuejun Luo, Guochao Zhang, Lide Wang, Qi Xue, Nan Sun, Jie He

Open Access Melanoma Original Article

PD-1+ mast cell enhanced by PD-1 blocking therapy associated with resistance to immunotherapy

Jun Li, Gang Peng, Kuikui Zhu, Xiaohua Jie, Yingzhuo Xu, Xinrui Rao, Yunhong Xu, Yunshang Chen, Biyuan Xing, Gang Wu, Liangliang Shi

NSCLC Original Article

Blockade of IL-1α and IL-1β signaling by the anti-IL1RAP antibody nadunolimab (CAN04) mediates synergistic anti-tumor efficacy with chemotherapy

Camilla Rydberg Millrud, Adnan Deronic, Caitríona Grönberg, Elin Jaensson Gyllenbäck, Karin von Wachenfeldt, Göran Forsberg, David Liberg

Breast Cancer Original Article

Single-cell and spatial transcriptome analyses revealed cell heterogeneity and immune environment alternations in metastatic axillary lymph nodes in breast cancer

Xiaofan Mao, Dan Zhou, Kairong Lin, Beiying Zhang, Juntao Gao, Fei Ling, Lewei Zhu, Sifei Yu, Peixian Chen, Chuling Zhang, Chunguo Zhang, Guolin Ye, Simon Fong, Guoqiang Chen, Wei Luo

Melanoma Original Article

Divergent clinical outcomes in a phase 2B trial of the TLPLDC vaccine in preventing melanoma recurrence and the impact of dendritic cell collection methodology: a randomized clinical trial

Alexandra M. Adams, Elizabeth L. Carpenter, Guy T. Clifton, Timothy J. Vreeland, Robert C. Chick, Anne E. O’Shea, Patrick M. McCarthy, Phillip M. Kemp Bohan, Annelies T. Hickerson, Franklin A. Valdera, Ankur Tiwari, Diane F. Hale, John R. Hyngstrom, Adam C. Berger, James W. Jakub, Jeffrey J. Sussman, Montaser F. Shaheen, Xianzhong Yu, Thomas E. Wagner, Mark B. Faries, George E. Peoples

Lymphoma Original Article

Compromised activity of natural killer cells in diffuse large b-cell lymphoma is related to lymphoma-induced modification of their surface receptor expression

Tehila Azoulay, Ilana Slouzky, Michal Karmona, Margarita Filatov, Michal Hayun, Yishai Ofran, Galit Sarig, Shimrit Ringelstein-Harlev

Melanoma Original Article

PD-L1 antibody enhanced β-glucan antitumor effects via blockade of the immune checkpoints in a melanoma model

Xin Hu, Yifang Shui, Hiroshi Hirano, Kisato Kusano, Wen-Zhi Guo, Masayuki Fujino, Xiao-Kang Li

Glioblastoma Original Article

Detecting monocyte trafficking in an animal model of glioblastoma using R2* and quantitative susceptibility mapping

Runze Yang, A. Max Hamilton, Hongfu Sun, Khalil S. Rawji, Susobhan Sarkar, Reza Mirzaei, G. Bruce Pike, V. Wee. Yong, Jeff F. Dunn

Open Access Urothelial Cancer Research Report

A blood-based immune marker for resistance to pembrolizumab in patients with metastatic urothelial cancer

Maud Rijnders, Debbie G. J. Robbrecht, Astrid A. M. Oostvogels, Mandy van Brakel, Joost L. Boormans, Maureen J. B. Aarts, Hayri E. Balcioglu, Paul Hamberg, Jens Voortman, Hans M. Westgeest, Martijn P. Lolkema, Ronald de Wit, Astrid A. M. van der Veldt, Reno Debets

Research Report

TCR extracellular domain genetically linked to CD28, 2B4/41BB and DAP10/CD3ζ -engineered NK cells mediates antitumor effects

Shance Li, Chaoting Zhang, Luyan Shen, Xia Teng, Yefei Xiao, Bentong Yu, Zheming Lu

Poxvirus Research Report

Phase II trial of CV301 vaccine combined with atezolizumab in advanced urothelial carcinoma

Guru P. Sonpavde, Benjamin Louis Maughan, Bradley Alexander McGregor, Xiao X. Wei, Kerry L. Kilbridge, Richard J. Lee, Evan Y. Yu, Michael Thomas Schweizer, Robert B. Montgomery, Heather H. Cheng, Andrew Caleb Hsieh, Rohit Jain, Jaspreet S. Grewal, Cesar Pico-Navarro, Zarina Gafoor, Teresa Perschy, Petros Grivas

NSCLC Research Report

The predictive value of inflammatory biomarkers for major pathological response in non-small cell lung cancer patients receiving neoadjuvant chemoimmunotherapy and its association with the immune-related tumor microenvironment: a multi-center study

Chongwu Li, Junqi Wu, Long Jiang, Lei Zhang, Jia Huang, Yu Tian, Yue Zhao, Xiucheng Liu, Lang Xia, Haoran E, Peigen Gao, Likun Hou, Minglei Yang, Minjie Ma, Chunxia Su, Hao Zhang, Hezhong Chen, Yunlang She, Dong Xie, Qingquan Luo, Chang Chen

NSCLC Correction

Correction to: The predictive value of inflammatory biomarkers for major pathological response in non-small cell lung cancer patients receiving neoadjuvant chemoimmunotherapy and its association with the immune-related tumor microenvironment: a multi-center study

Chongwu Li, Junqi Wu, Long Jiang, Lei Zhang, Jia Huang, Yu Tian, Yue Zhao, Xiucheng Liu, Lang Xia, Haoran E, Peigen Gao, Likun Hou, Minglei Yang, Minjie Ma, Chunxia Su, Hao Zhang, Hezhong Chen, Yunlang She, Dong Xie, Qingquan Luo, Chang Chen

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine