Skip to main content
Top
Published in: European Journal of Nutrition 5/2015

01-08-2015 | Original Contribution

Can the use of blood-based biomarkers in addition to anthropometric indices substantially improve the prediction of visceral fat volume as measured by magnetic resonance imaging?

Authors: Jasmine Neamat-Allah, Theron Johnson, Diana Nabers, Anika Hüsing, Birgit Teucher, Verena Katzke, Stefan Delorme, Rudolf Kaaks, Tilman Kühn

Published in: European Journal of Nutrition | Issue 5/2015

Login to get access

Abstract

Purpose

To investigate whether blood-based biomarkers can improve the prediction of visceral fat volume as measured by magnetic resonance imaging (MRI) and thus be used as proxies of visceral adiposity in large-scale epidemiological studies.

Methods

Whole-body MRI was performed to determine overall and regional body compartments in 542 participants aged 48–80 years (52 % men) of the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition. Anthropometric measures were taken, and clinical chemistry profiles including 15 routine biomarkers were obtained. Furthermore, nine novel biomarkers of visceral fat were assayed in a discovery sample of 100 participants. Multivariable regression models were calculated to assess associations between anthropometric variables, biomarkers, and visceral fat volume.

Results

The proportion of variance in visceral fat volume explained by anthropometric measures was 65.2 % in women and 60.8 % in men. By using blood-based biomarkers in addition to anthropometric indices, the variance in visceral fat volume explained could be increased by 4.8 % in women and 4.0 % in men. After backward selection, HbA1c, triglycerides, and adiponectin remained in the final multivariable regression model in women, while in men hsCRP, leukocytes, AST (GOT), GGT, LDL, and adiponectin remained in the final model.

Conclusions

In the present study, blood-based biomarkers moderately improved the prediction of visceral fat volume. This finding suggests that the underestimation of true associations between visceral fat and disease outcomes in epidemiological studies remains critical, even when using comprehensive sets of anthropometric and biomarker variables as proxies of visceral adiposity.
Appendix
Available only for authorised users
Literature
3.
go back to reference Sowers JR (2003) Obesity as a cardiovascular risk factor. Am J Med 115(Suppl 8A):37S–41SCrossRef Sowers JR (2003) Obesity as a cardiovascular risk factor. Am J Med 115(Suppl 8A):37S–41SCrossRef
4.
5.
go back to reference Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M (2008) Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371(9612):569–578. doi:10.1016/S0140-6736(08)60269-X CrossRef Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M (2008) Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371(9612):569–578. doi:10.​1016/​S0140-6736(08)60269-X CrossRef
7.
go back to reference Ross R, Janssen I (2005) Computed tomography and magnetic resonance imaging. In: Heymsfield SB, Lohman TG, Wang Z,Going SB (eds) Human Body Composition, 2nd edn. Human Kinetics, Champaign, pp 89–108 Ross R, Janssen I (2005) Computed tomography and magnetic resonance imaging. In: Heymsfield SB, Lohman TG, Wang Z,Going SB (eds) Human Body Composition, 2nd edn. Human Kinetics, Champaign, pp 89–108
8.
go back to reference Neamat-Allah J, Wald D, Husing A, Teucher B, Wendt A, Delorme S, Dinkel J, Vigl M, Bergmann MM, Feller S, Hierholzer J, Boeing H, Kaaks R (2014) Validation of anthropometric indices of adiposity against whole-body magnetic resonance imaging: a study within the German European Prospective Investigation into Cancer and Nutrition (EPIC) cohorts. PLoS One 9(3):e91586. doi:10.1371/journal.pone.0091586 CrossRef Neamat-Allah J, Wald D, Husing A, Teucher B, Wendt A, Delorme S, Dinkel J, Vigl M, Bergmann MM, Feller S, Hierholzer J, Boeing H, Kaaks R (2014) Validation of anthropometric indices of adiposity against whole-body magnetic resonance imaging: a study within the German European Prospective Investigation into Cancer and Nutrition (EPIC) cohorts. PLoS One 9(3):e91586. doi:10.​1371/​journal.​pone.​0091586 CrossRef
9.
go back to reference Brambilla P, Bedogni G, Moreno LA, Goran MI, Gutin B, Fox KR, Peters DM, Barbeau P, De Simone M, Pietrobelli A (2006) Cross validation of anthropometry against magnetic resonance imaging for the assessment of visceral and subcutaneous adipose tissue in children. Int J Obes (Lond) 30(1):23–30. doi:10.1038/sj.ijo.0803163 CrossRef Brambilla P, Bedogni G, Moreno LA, Goran MI, Gutin B, Fox KR, Peters DM, Barbeau P, De Simone M, Pietrobelli A (2006) Cross validation of anthropometry against magnetic resonance imaging for the assessment of visceral and subcutaneous adipose tissue in children. Int J Obes (Lond) 30(1):23–30. doi:10.​1038/​sj.​ijo.​0803163 CrossRef
10.
go back to reference Thomas EL, Parkinson JR, Frost GS, Goldstone AP, Dore CJ, McCarthy JP, Collins AL, Fitzpatrick JA, Durighel G, Taylor-Robinson SD, Bell JD (2012) The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat. Obesity (Silver Spring) 20(1):76–87. doi:10.1038/oby.2011.142 CrossRef Thomas EL, Parkinson JR, Frost GS, Goldstone AP, Dore CJ, McCarthy JP, Collins AL, Fitzpatrick JA, Durighel G, Taylor-Robinson SD, Bell JD (2012) The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat. Obesity (Silver Spring) 20(1):76–87. doi:10.​1038/​oby.​2011.​142 CrossRef
11.
go back to reference Springer F, Ehehalt S, Sommer J, Ballweg V, Machann J, Binder G, Claussen CD, Schick F, Group DI-S (2012) Predicting volumes of metabolically important whole-body adipose tissue compartments in overweight and obese adolescents by different MRI approaches and anthropometry. Eur J Radiol 81(7):1488–1494. doi:10.1016/j.ejrad.2011.04.006 CrossRef Springer F, Ehehalt S, Sommer J, Ballweg V, Machann J, Binder G, Claussen CD, Schick F, Group DI-S (2012) Predicting volumes of metabolically important whole-body adipose tissue compartments in overweight and obese adolescents by different MRI approaches and anthropometry. Eur J Radiol 81(7):1488–1494. doi:10.​1016/​j.​ejrad.​2011.​04.​006 CrossRef
12.
go back to reference Bonora E, Micciolo R, Ghiatas AA, Lancaster JL, Alyassin A, Muggeo M, DeFronzo RA (1995) Is it possible to derive a reliable estimate of human visceral and subcutaneous abdominal adipose tissue from simple anthropometric measurements? Metabolism 44(12):1617–1625CrossRef Bonora E, Micciolo R, Ghiatas AA, Lancaster JL, Alyassin A, Muggeo M, DeFronzo RA (1995) Is it possible to derive a reliable estimate of human visceral and subcutaneous abdominal adipose tissue from simple anthropometric measurements? Metabolism 44(12):1617–1625CrossRef
13.
go back to reference Ludescher B, Machann J, Eschweiler GW, Vanhofen S, Maenz C, Thamer C, Claussen CD, Schick F (2009) Correlation of fat distribution in whole body MRI with generally used anthropometric data. Invest Radiol 44(11):712–719. doi:10.1097/RLI.0b013e3181afbb1e CrossRef Ludescher B, Machann J, Eschweiler GW, Vanhofen S, Maenz C, Thamer C, Claussen CD, Schick F (2009) Correlation of fat distribution in whole body MRI with generally used anthropometric data. Invest Radiol 44(11):712–719. doi:10.​1097/​RLI.​0b013e3181afbb1e​ CrossRef
14.
go back to reference Ross R, Leger L, Morris D, de Guise J, Guardo R (1992) Quantification of adipose tissue by MRI: relationship with anthropometric variables. J Appl Physiol 72(2):787–795 Ross R, Leger L, Morris D, de Guise J, Guardo R (1992) Quantification of adipose tissue by MRI: relationship with anthropometric variables. J Appl Physiol 72(2):787–795
15.
go back to reference Poll L, Wittsack HJ, Willers R, Modder U, Heinemann L, Kapitza C, Rave K (2004) Correlation between anthropometric parameters and abdominal fat volumes assessed by a magnetic resonance imaging method in patients with diabetes. Diabetes Technol Ther 6(6):844–849. doi:10.1089/dia.2004.6.844 CrossRef Poll L, Wittsack HJ, Willers R, Modder U, Heinemann L, Kapitza C, Rave K (2004) Correlation between anthropometric parameters and abdominal fat volumes assessed by a magnetic resonance imaging method in patients with diabetes. Diabetes Technol Ther 6(6):844–849. doi:10.​1089/​dia.​2004.​6.​844 CrossRef
17.
go back to reference Gavrila A, Chan JL, Yiannakouris N, Kontogianni M, Miller LC, Orlova C, Mantzoros CS (2003) Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans: cross-sectional and interventional studies. J Clin Endocrinol Metab 88(10):4823–4831. doi:10.1210/jc.2003-030214 CrossRef Gavrila A, Chan JL, Yiannakouris N, Kontogianni M, Miller LC, Orlova C, Mantzoros CS (2003) Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans: cross-sectional and interventional studies. J Clin Endocrinol Metab 88(10):4823–4831. doi:10.​1210/​jc.​2003-030214 CrossRef
18.
go back to reference Cnop M, Havel PJ, Utzschneider KM, Carr DB, Sinha MK, Boyko EJ, Retzlaff BM, Knopp RH, Brunzell JD, Kahn SE (2003) Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia 46(4):459–469. doi:10.1007/s00125-003-1074-z Cnop M, Havel PJ, Utzschneider KM, Carr DB, Sinha MK, Boyko EJ, Retzlaff BM, Knopp RH, Brunzell JD, Kahn SE (2003) Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia 46(4):459–469. doi:10.​1007/​s00125-003-1074-z
20.
go back to reference Canale MP, Manca di Villahermosa S, Martino G, Rovella V, Noce A, De Lorenzo A, Di Daniele N (2013) Obesity-related metabolic syndrome: mechanisms of sympathetic overactivity. Int J Endocrinol 2013:865965. doi:10.1155/2013/865965 CrossRef Canale MP, Manca di Villahermosa S, Martino G, Rovella V, Noce A, De Lorenzo A, Di Daniele N (2013) Obesity-related metabolic syndrome: mechanisms of sympathetic overactivity. Int J Endocrinol 2013:865965. doi:10.​1155/​2013/​865965 CrossRef
22.
go back to reference Naour N, Fellahi S, Renucci JF, Poitou C, Rouault C, Basdevant A, Dutour A, Alessi MC, Bastard JP, Clement K, Guerre-Millo M (2009) Potential contribution of adipose tissue to elevated serum cystatin C in human obesity. Obesity (Silver Spring) 17(12):2121–2126. doi:10.1038/oby.2009.96 CrossRef Naour N, Fellahi S, Renucci JF, Poitou C, Rouault C, Basdevant A, Dutour A, Alessi MC, Bastard JP, Clement K, Guerre-Millo M (2009) Potential contribution of adipose tissue to elevated serum cystatin C in human obesity. Obesity (Silver Spring) 17(12):2121–2126. doi:10.​1038/​oby.​2009.​96 CrossRef
23.
go back to reference Chew-Harris JS, Florkowski CM, George PM, Elmslie JL, Endre ZH (2013) The relative effects of fat versus muscle mass on cystatin C and estimates of renal function in healthy young men. Ann Clin Biochem 50(Pt 1):39–46. doi:10.1258/acb.2012.011241 CrossRef Chew-Harris JS, Florkowski CM, George PM, Elmslie JL, Endre ZH (2013) The relative effects of fat versus muscle mass on cystatin C and estimates of renal function in healthy young men. Ann Clin Biochem 50(Pt 1):39–46. doi:10.​1258/​acb.​2012.​011241 CrossRef
24.
go back to reference Kloting N, Graham TE, Berndt J, Kralisch S, Kovacs P, Wason CJ, Fasshauer M, Schon MR, Stumvoll M, Bluher M, Kahn BB (2007) Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass. Cell Metab 6(1):79–87. doi:10.1016/j.cmet.2007.06.002 CrossRef Kloting N, Graham TE, Berndt J, Kralisch S, Kovacs P, Wason CJ, Fasshauer M, Schon MR, Stumvoll M, Bluher M, Kahn BB (2007) Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass. Cell Metab 6(1):79–87. doi:10.​1016/​j.​cmet.​2007.​06.​002 CrossRef
25.
go back to reference Lee JW, Im JA, Lee HR, Shim JY, Youn BS, Lee DC (2007) Visceral adiposity is associated with serum retinol binding protein-4 levels in healthy women. Obesity (Silver Spring) 15(9):2225–2232. doi:10.1038/oby.2007.264 CrossRef Lee JW, Im JA, Lee HR, Shim JY, Youn BS, Lee DC (2007) Visceral adiposity is associated with serum retinol binding protein-4 levels in healthy women. Obesity (Silver Spring) 15(9):2225–2232. doi:10.​1038/​oby.​2007.​264 CrossRef
26.
go back to reference Engeli S, Utz W, Haufe S, Lamounier-Zepter V, Pofahl M, Traber J, Janke J, Luft FC, Boschmann M, Schulz-Menger J, Jordan J (2013) Fatty acid binding protein 4 predicts left ventricular mass and longitudinal function in overweight and obese women. Heart 99(13):944–948. doi:10.1136/heartjnl-2013-303735 CrossRef Engeli S, Utz W, Haufe S, Lamounier-Zepter V, Pofahl M, Traber J, Janke J, Luft FC, Boschmann M, Schulz-Menger J, Jordan J (2013) Fatty acid binding protein 4 predicts left ventricular mass and longitudinal function in overweight and obese women. Heart 99(13):944–948. doi:10.​1136/​heartjnl-2013-303735 CrossRef
27.
go back to reference Gonzalez-Quintela A, Alonso M, Campos J, Vizcaino L, Loidi L, Gude F (2013) Determinants of serum concentrations of lipopolysaccharide-binding protein (LBP) in the adult population: the role of obesity. PLoS One 8(1):e54600. doi:10.1371/journal.pone.0054600 CrossRef Gonzalez-Quintela A, Alonso M, Campos J, Vizcaino L, Loidi L, Gude F (2013) Determinants of serum concentrations of lipopolysaccharide-binding protein (LBP) in the adult population: the role of obesity. PLoS One 8(1):e54600. doi:10.​1371/​journal.​pone.​0054600 CrossRef
28.
go back to reference Moreno-Navarrete JM, Escote X, Ortega F, Serino M, Campbell M, Michalski MC, Laville M, Xifra G, Luche E, Domingo P, Sabater M, Pardo G, Waget A, Salvador J, Giralt M, Rodriguez-Hermosa JI, Camps M, Kolditz CI, Viguerie N, Galitzky J, Decaunes P, Ricart W, Fruhbeck G, Villarroya F, Mingrone G, Langin D, Zorzano A, Vidal H, Vendrell J, Burcelin R, Vidal-Puig A, Fernandez-Real JM (2013) A role for adipocyte-derived lipopolysaccharide-binding protein in inflammation- and obesity-associated adipose tissue dysfunction. Diabetologia 56(11):2524–2537. doi:10.1007/s00125-013-3015-9 CrossRef Moreno-Navarrete JM, Escote X, Ortega F, Serino M, Campbell M, Michalski MC, Laville M, Xifra G, Luche E, Domingo P, Sabater M, Pardo G, Waget A, Salvador J, Giralt M, Rodriguez-Hermosa JI, Camps M, Kolditz CI, Viguerie N, Galitzky J, Decaunes P, Ricart W, Fruhbeck G, Villarroya F, Mingrone G, Langin D, Zorzano A, Vidal H, Vendrell J, Burcelin R, Vidal-Puig A, Fernandez-Real JM (2013) A role for adipocyte-derived lipopolysaccharide-binding protein in inflammation- and obesity-associated adipose tissue dysfunction. Diabetologia 56(11):2524–2537. doi:10.​1007/​s00125-013-3015-9 CrossRef
30.
go back to reference Amato MC, Pizzolanti G, Torregrossa V, Misiano G, Milano S, Giordano C (2014) Visceral adiposity index (VAI) is predictive of an altered adipokine profile in patients with type 2 diabetes. PLoS One 9(3):e91969. doi:10.1371/journal.pone.0091969 CrossRef Amato MC, Pizzolanti G, Torregrossa V, Misiano G, Milano S, Giordano C (2014) Visceral adiposity index (VAI) is predictive of an altered adipokine profile in patients with type 2 diabetes. PLoS One 9(3):e91969. doi:10.​1371/​journal.​pone.​0091969 CrossRef
31.
go back to reference Miyazaki Y, DeFronzo RA (2009) Visceral fat dominant distribution in male type 2 diabetic patients is closely related to hepatic insulin resistance, irrespective of body type. Cardiovasc Diabetol 8:44. doi:10.1186/1475-2840-8-44 CrossRef Miyazaki Y, DeFronzo RA (2009) Visceral fat dominant distribution in male type 2 diabetic patients is closely related to hepatic insulin resistance, irrespective of body type. Cardiovasc Diabetol 8:44. doi:10.​1186/​1475-2840-8-44 CrossRef
32.
go back to reference Shiina Y, Homma Y (2013) Relationships between the visceral fat area on CT and coronary risk factor markers. Intern Med 52(16):1775–1780CrossRef Shiina Y, Homma Y (2013) Relationships between the visceral fat area on CT and coronary risk factor markers. Intern Med 52(16):1775–1780CrossRef
33.
go back to reference Verrijken A, Francque S, Mertens I, Talloen M, Peiffer F, Van Gaal L (2010) Visceral adipose tissue and inflammation correlate with elevated liver tests in a cohort of overweight and obese patients. Int J Obes (Lond) 34(5):899–907. doi:10.1038/ijo.2010.4 CrossRef Verrijken A, Francque S, Mertens I, Talloen M, Peiffer F, Van Gaal L (2010) Visceral adipose tissue and inflammation correlate with elevated liver tests in a cohort of overweight and obese patients. Int J Obes (Lond) 34(5):899–907. doi:10.​1038/​ijo.​2010.​4 CrossRef
35.
go back to reference Riboli E, Hunt KJ, Slimani N, Ferrari P, Norat T, Fahey M, Charrondiere UR, Hemon B, Casagrande C, Vignat J, Overvad K, Tjonneland A, Clavel-Chapelon F, Thiebaut A, Wahrendorf J, Boeing H, Trichopoulos D, Trichopoulou A, Vineis P, Palli D, Bueno-De-Mesquita HB, Peeters PH, Lund E, Engeset D, Gonzalez CA, Barricarte A, Berglund G, Hallmans G, Day NE, Key TJ, Kaaks R, Saracci R (2002) European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection. Public Health Nutr 5(6B):1113–1124. doi:10.1079/PHN2002394 CrossRef Riboli E, Hunt KJ, Slimani N, Ferrari P, Norat T, Fahey M, Charrondiere UR, Hemon B, Casagrande C, Vignat J, Overvad K, Tjonneland A, Clavel-Chapelon F, Thiebaut A, Wahrendorf J, Boeing H, Trichopoulos D, Trichopoulou A, Vineis P, Palli D, Bueno-De-Mesquita HB, Peeters PH, Lund E, Engeset D, Gonzalez CA, Barricarte A, Berglund G, Hallmans G, Day NE, Key TJ, Kaaks R, Saracci R (2002) European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection. Public Health Nutr 5(6B):1113–1124. doi:10.​1079/​PHN2002394 CrossRef
36.
go back to reference Boeing H, Wahrendorf J, Becker N (1999) EPIC-Germany: a source for studies into diet and risk of chronic diseases. European investigation into cancer and nutrition. Ann Nutr Metab 43(4):195–204. doi:10.1159/000012786 CrossRef Boeing H, Wahrendorf J, Becker N (1999) EPIC-Germany: a source for studies into diet and risk of chronic diseases. European investigation into cancer and nutrition. Ann Nutr Metab 43(4):195–204. doi:10.​1159/​000012786 CrossRef
37.
go back to reference Wald D, Teucher B, Dinkel J, Kaaks R, Delorme S, Boeing H, Seidensaal K, Meinzer HP, Heimann T (2012) Automatic quantification of subcutaneous and visceral adipose tissue from whole-body magnetic resonance images suitable for large cohort studies. J Magn Reson Imaging. doi:10.1002/jmri.23775 Wald D, Teucher B, Dinkel J, Kaaks R, Delorme S, Boeing H, Seidensaal K, Meinzer HP, Heimann T (2012) Automatic quantification of subcutaneous and visceral adipose tissue from whole-body magnetic resonance images suitable for large cohort studies. J Magn Reson Imaging. doi:10.​1002/​jmri.​23775
38.
go back to reference Wald D, Teucher B, Dinkel J, Kaaks R, Delorme S, Boeing H, Seidensaal K, Meinzer HP, Heimann T (2012) Automated quantification of adipose and skeletal muscle tissue in whole-body MRI data for epidemiological studies. Medical Imaging 2012: Computer-Aided Diagnosis. In: van Ginneken B, Novak CL (eds) Proceedings of the SPIE, Vol 8315, Article ID 831519, p 7 Wald D, Teucher B, Dinkel J, Kaaks R, Delorme S, Boeing H, Seidensaal K, Meinzer HP, Heimann T (2012) Automated quantification of adipose and skeletal muscle tissue in whole-body MRI data for epidemiological studies. Medical Imaging 2012: Computer-Aided Diagnosis. In: van Ginneken B, Novak CL (eds) Proceedings of the SPIE, Vol 8315, Article ID 831519, p 7
39.
go back to reference Willett WC, Howe GR, Kushi LH (1997) Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr 65(4 Suppl):1220S–1228S; discussion 1229S-1231S Willett WC, Howe GR, Kushi LH (1997) Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr 65(4 Suppl):1220S–1228S; discussion 1229S-1231S
40.
go back to reference Harrell FE (2001) Resampling, Validating, describing, and simplifying the model. In: Regression modeling strategies. Springer, New York, p 87–103 Harrell FE (2001) Resampling, Validating, describing, and simplifying the model. In: Regression modeling strategies. Springer, New York, p 87–103
41.
go back to reference Frederiksen L, Nielsen TL, Wraae K, Hagen C, Frystyk J, Flyvbjerg A, Brixen K, Andersen M (2009) Subcutaneous rather than visceral adipose tissue is associated with adiponectin levels and insulin resistance in young men. J Clin Endocrinol Metab 94(10):4010–4015. doi:10.1210/jc.2009-0980 CrossRef Frederiksen L, Nielsen TL, Wraae K, Hagen C, Frystyk J, Flyvbjerg A, Brixen K, Andersen M (2009) Subcutaneous rather than visceral adipose tissue is associated with adiponectin levels and insulin resistance in young men. J Clin Endocrinol Metab 94(10):4010–4015. doi:10.​1210/​jc.​2009-0980 CrossRef
42.
go back to reference Kishida K, Kim KK, Funahashi T, Matsuzawa Y, Kang HC, Shimomura I (2011) Relationships between circulating adiponectin levels and fat distribution in obese subjects. J Atheroscler Thromb 18(7):592–595CrossRef Kishida K, Kim KK, Funahashi T, Matsuzawa Y, Kang HC, Shimomura I (2011) Relationships between circulating adiponectin levels and fat distribution in obese subjects. J Atheroscler Thromb 18(7):592–595CrossRef
43.
go back to reference Athyros VG, Tziomalos K, Karagiannis A, Anagnostis P, Mikhailidis DP (2010) Should adipokines be considered in the choice of the treatment of obesity-related health problems? Curr Drug Targets 11(1):122–135CrossRef Athyros VG, Tziomalos K, Karagiannis A, Anagnostis P, Mikhailidis DP (2010) Should adipokines be considered in the choice of the treatment of obesity-related health problems? Curr Drug Targets 11(1):122–135CrossRef
46.
go back to reference Yaghootkar H, Lamina C, Scott RA, Dastani Z, Hivert MF, Warren LL, Stancakova A, Buxbaum SG, Lyytikainen LP, Henneman P, Wu Y, Cheung CY, Pankow JS, Jackson AU, Gustafsson S, Zhao JH, Ballantyne CM, Xie W, Bergman RN, Boehnke M, el Bouazzaoui F, Collins FS, Dunn SH, Dupuis J, Forouhi NG, Gillson C, Hattersley AT, Hong J, Kahonen M, Kuusisto J, Kedenko L, Kronenberg F, Doria A, Assimes TL, Ferrannini E, Hansen T, Hao K, Haring H, Knowles JW, Lindgren CM, Nolan JJ, Paananen J, Pedersen O, Quertermous T, Smith U, Consortium G, Consortium R, Lehtimaki T, Liu CT, Loos RJ, McCarthy MI, Morris AD, Vasan RS, Spector TD, Teslovich TM, Tuomilehto J, van Dijk KW, Viikari JS, Zhu N, Langenberg C, Ingelsson E, Semple RK, Sinaiko AR, Palmer CN, Walker M, Lam KS, Paulweber B, Mohlke KL, van Duijn C, Raitakari OT, Bidulescu A, Wareham NJ, Laakso M, Waterworth DM, Lawlor DA, Meigs JB, Richards JB,Frayling TM (2013) Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes. Diabetes 62 (10):3589–3598. doi:10.2337/db13-0128 Yaghootkar H, Lamina C, Scott RA, Dastani Z, Hivert MF, Warren LL, Stancakova A, Buxbaum SG, Lyytikainen LP, Henneman P, Wu Y, Cheung CY, Pankow JS, Jackson AU, Gustafsson S, Zhao JH, Ballantyne CM, Xie W, Bergman RN, Boehnke M, el Bouazzaoui F, Collins FS, Dunn SH, Dupuis J, Forouhi NG, Gillson C, Hattersley AT, Hong J, Kahonen M, Kuusisto J, Kedenko L, Kronenberg F, Doria A, Assimes TL, Ferrannini E, Hansen T, Hao K, Haring H, Knowles JW, Lindgren CM, Nolan JJ, Paananen J, Pedersen O, Quertermous T, Smith U, Consortium G, Consortium R, Lehtimaki T, Liu CT, Loos RJ, McCarthy MI, Morris AD, Vasan RS, Spector TD, Teslovich TM, Tuomilehto J, van Dijk KW, Viikari JS, Zhu N, Langenberg C, Ingelsson E, Semple RK, Sinaiko AR, Palmer CN, Walker M, Lam KS, Paulweber B, Mohlke KL, van Duijn C, Raitakari OT, Bidulescu A, Wareham NJ, Laakso M, Waterworth DM, Lawlor DA, Meigs JB, Richards JB,Frayling TM (2013) Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes. Diabetes 62 (10):3589–3598. doi:10.​2337/​db13-0128
47.
go back to reference Lim U, Turner SD, Franke AA, Cooney RV, Wilkens LR, Ernst T, Albright CL, Novotny R, Chang L, Kolonel LN, Murphy SP, Le Marchand L (2012) Predicting total, abdominal, visceral and hepatic adiposity with circulating biomarkers in Caucasian and Japanese American women. PLoS One 7(8):e43502. doi:10.1371/journal.pone.0043502 CrossRef Lim U, Turner SD, Franke AA, Cooney RV, Wilkens LR, Ernst T, Albright CL, Novotny R, Chang L, Kolonel LN, Murphy SP, Le Marchand L (2012) Predicting total, abdominal, visceral and hepatic adiposity with circulating biomarkers in Caucasian and Japanese American women. PLoS One 7(8):e43502. doi:10.​1371/​journal.​pone.​0043502 CrossRef
48.
go back to reference Wichmann HE, Kaaks R, Hoffmann W, Jockel KH, Greiser KH, Linseisen J (2012) The German national cohort. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 55(6–7):781–787CrossRef Wichmann HE, Kaaks R, Hoffmann W, Jockel KH, Greiser KH, Linseisen J (2012) The German national cohort. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 55(6–7):781–787CrossRef
49.
go back to reference Mahabadi AA, Massaro JM, Rosito GA, Levy D, Murabito JM, Wolf PA, O’Donnell CJ, Fox CS, Hoffmann U (2009) Association of pericardial fat, intrathoracic fat, and visceral abdominal fat with cardiovascular disease burden: the Framingham heart study. Eur Heart J 30(7):850–856. doi:10.1093/eurheartj/ehn573 CrossRef Mahabadi AA, Massaro JM, Rosito GA, Levy D, Murabito JM, Wolf PA, O’Donnell CJ, Fox CS, Hoffmann U (2009) Association of pericardial fat, intrathoracic fat, and visceral abdominal fat with cardiovascular disease burden: the Framingham heart study. Eur Heart J 30(7):850–856. doi:10.​1093/​eurheartj/​ehn573 CrossRef
50.
go back to reference Neeland IJ, Turer AT, Ayers CR, Powell-Wiley TM, Vega GL, Farzaneh-Far R, Grundy SM, Khera A, McGuire DK, de Lemos JA (2012) Dysfunctional adiposity and the risk of prediabetes and type 2 diabetes in obese adults. JAMA 308(11):1150–1159. doi:10.1001/2012.jama.11132 CrossRef Neeland IJ, Turer AT, Ayers CR, Powell-Wiley TM, Vega GL, Farzaneh-Far R, Grundy SM, Khera A, McGuire DK, de Lemos JA (2012) Dysfunctional adiposity and the risk of prediabetes and type 2 diabetes in obese adults. JAMA 308(11):1150–1159. doi:10.​1001/​2012.​jama.​11132 CrossRef
51.
go back to reference Nicklas BJ, Penninx BW, Cesari M, Kritchevsky SB, Newman AB, Kanaya AM, Pahor M, Jingzhong D, Harris TB, Health Aging Body Composition Study (2004) Association of visceral adipose tissue with incident myocardial infarction in older men and women: the health, aging and body composition study. Am J Epidemiol 160(8):741–749. doi:10.1093/aje/kwh281 CrossRef Nicklas BJ, Penninx BW, Cesari M, Kritchevsky SB, Newman AB, Kanaya AM, Pahor M, Jingzhong D, Harris TB, Health Aging Body Composition Study (2004) Association of visceral adipose tissue with incident myocardial infarction in older men and women: the health, aging and body composition study. Am J Epidemiol 160(8):741–749. doi:10.​1093/​aje/​kwh281 CrossRef
52.
go back to reference Rickles AS, Iannuzzi JC, Mironov O, Deeb AP, Sharma A, Fleming FJ, Monson JR (2013) Visceral obesity and colorectal cancer: are we missing the boat with BMI? J Gastrointest Surg 17 (1):133-143; discussion p 143. doi:10.1007/s11605-012-2045-9 Rickles AS, Iannuzzi JC, Mironov O, Deeb AP, Sharma A, Fleming FJ, Monson JR (2013) Visceral obesity and colorectal cancer: are we missing the boat with BMI? J Gastrointest Surg 17 (1):133-143; discussion p 143. doi:10.​1007/​s11605-012-2045-9
Metadata
Title
Can the use of blood-based biomarkers in addition to anthropometric indices substantially improve the prediction of visceral fat volume as measured by magnetic resonance imaging?
Authors
Jasmine Neamat-Allah
Theron Johnson
Diana Nabers
Anika Hüsing
Birgit Teucher
Verena Katzke
Stefan Delorme
Rudolf Kaaks
Tilman Kühn
Publication date
01-08-2015
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nutrition / Issue 5/2015
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-014-0748-2

Other articles of this Issue 5/2015

European Journal of Nutrition 5/2015 Go to the issue
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.