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Published in: Lung 2/2024

27-03-2024 | Buprenorphine | DYSPHAGIA and PNEUMONIA

Dysphagia as a Missing Link Between Post-surgical- and Opioid-Related Pneumonia

Authors: Michael Frazure, Clinton L. Greene, Kimberly E. Iceman, Dena R. Howland, Teresa Pitts

Published in: Lung | Issue 2/2024

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Abstract

Purpose

Postoperative pneumonia remains a common complication of surgery, despite increased attention. The purpose of our study was to determine the effects of routine surgery and post-surgical opioid administration on airway protection risk.

Methods

Eight healthy adult cats were evaluated to determine changes in airway protection status and for evidence of dysphagia in two experiments. (1) In four female cats, airway protection status was tracked following routine abdominal surgery (spay surgery) plus low-dose opioid administration (buprenorphine 0.015 mg/kg, IM, q8-12 h; n = 5). (2) Using a cross-over design, four naive cats (2 male, 2 female) were treated with moderate-dose (0.02 mg/kg) or high-dose (0.04 mg/kg) buprenorphine (IM, q8-12 h; n = 5).

Results

Airway protection was significantly affected in both experiments, but the most severe deficits occurred post-surgically as 75% of the animals exhibited silent aspiration.

Conclusion

Oropharyngeal swallow is impaired by the partial mu-opioid receptor agonist buprenorphine, most remarkably in the postoperative setting. These findings have implications for the prevention and management of aspiration pneumonia in vulnerable populations.
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Metadata
Title
Dysphagia as a Missing Link Between Post-surgical- and Opioid-Related Pneumonia
Authors
Michael Frazure
Clinton L. Greene
Kimberly E. Iceman
Dena R. Howland
Teresa Pitts
Publication date
27-03-2024
Publisher
Springer US
Published in
Lung / Issue 2/2024
Print ISSN: 0341-2040
Electronic ISSN: 1432-1750
DOI
https://doi.org/10.1007/s00408-024-00672-8

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