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Advances in Therapy

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01-02-2022 | Breast Cancer | Review

Role of Exemestane in the Treatment of Estrogen-Receptor-Positive Breast Cancer: A Narrative Review of Recent Evidence

Authors: Yongmei Wang, Fanbo Jing, Haibo Wang

Published in: Advances in Therapy | Issue 2/2022

Abstract

Introduction

Breast cancer (BC) is the most common type of cancer diagnosed among women worldwide with an estimated 2.3 million new cases every year. Almost two-thirds of all patients with BC have estrogen receptor-positive (ER+) tumors. In this review, the clinical evidence of exemestane in different treatment settings in ER+ BC is presented and summarized.

Search strategy

A search strategy with the keywords “breast cancer [MeSH Terms]” AND “exemestane [Title/Abstract]” was devised and a search was performed in PubMed.

Results

The efficacy of exemestane in different treatment settings has been established by numerous clinical studies. Exemestane is recommended as an adjuvant treatment in postmenopausal women previously treated with tamoxifen in trials comparing 5 years of tamoxifen with 2–3 years of tamoxifen combined with 2–3 years of exemestane, which proved that treatment with exemestane provided better survival outcomes. Similarly, exemestane could be considered as a safe treatment option for neoadjuvant treatment, prevention of chemotherapy, and treatment of advanced BC either alone or in combination with other targeted therapy drugs in both pre- and postmenopausal women.

Conclusion

Exemestane could be considered as a reasonable therapeutic option in the treatment of ER+ BC at any stage in pre- and postmenopausal women.

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Title: Role of Exemestane in the Treatment of Estrogen-Receptor-Positive Breast Cancer: A Narrative Review of Recent Evidence
Authors: Yongmei Wang
Fanbo Jing
Haibo Wang
Publication date: 01-02-2022
Publisher: Springer Healthcare
Keywords: Breast Cancer
Breast Cancer
Exemestane
Tamoxifen
Fulvestrant
Estrogens
Anastrozole
Everolimus
Published in: Advances in Therapy / Issue 2/2022
Print ISSN: 0741-238X
Electronic ISSN: 1865-8652
DOI: https://doi.org/10.1007/s12325-021-01924-2

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