Published in:
Open Access
01-12-2014 | Research article
Blood pressure values and depression in hypertensive individuals at high cardiovascular risk
Authors:
Cilia Mejia-Lancheros, Ramón Estruch, Miguel Angel Martínez-González, Jordi Salas-Salvadó, Dolores Corella, Enrique Gómez-Gracia, Miquel Fiol, José Manuel Santos, Montse Fitó, Fernando Arós, Lluis Serra-Majem, Xavier Pintó, Josep Basora, José Vicente Sorlí, Miguel-Angel Muñoz, the PREDIMED Study Investigators
Published in:
BMC Cardiovascular Disorders
|
Issue 1/2014
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Abstract
Background
Hypertension and depression are both important risk factors for cardiovascular diseases. Nevertheless, the association of blood pressure on and depression has not been completely established. This study aims to analyze whether depression may influence the control of blood pressure in hypertensive individuals at high cardiovascular risk.
Methods
Cross-sectional study, embedded within the PREDIMED clinical trial, of 5954 hypertensive patients with high cardiovascular risk factor profiles. The relationship between blood pressure control and depression was analyzed. A multivariate analysis (logistic and log-linear regression), adjusting for potential confounders (socio-demographic factors, body mass index, lifestyle, diabetes, dyslipidemia, and antihypertensive treatment), was performed.
Results
Depressive patients, with and without antidepressant treatment, had better blood pressure control (OR: 1.28, CI 95%: 1.06-1.55, and OR: 1.30, CI 95%: 1.03-1.65, respectively) than non-depressive ones. Regarding blood pressure levels, systolic blood pressure values (mmHg) were found to be lower in both treated and untreated depressive patients (Log coefficient Beta: -1.59, 95% CI: -0.50 to -2.69 and Log coefficient Beta: -3.49, 95% CI: -2.10 to -4.87, respectively).
Conclusions
Among hypertensive patients at high cardiovascular risk, the control of blood pressure was better in those diagnosed with depression.