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01-06-2020 | Biomarkers | Original Contribution

Dietary patterns associated with inflammatory biomarkers in a Northern German population

Authors: Janett Barbaresko, Johanna Rienks, Kolade Oluwagbemigun, Gunnar Jacobs, Wolfgang Lieb, Matthias Laudes, Ute Nöthlings

Published in: European Journal of Nutrition | Issue 4/2020

Abstract

Purpose

The aim of the present study was to derive overall and sex-specific dietary patterns associated with inflammatory biomarkers in a general population sample from Northern Germany.

Methods

The present analysis included 1158 participants (477 men, 681 women, mean age: 53.1 years; mean body mass index: 26.2 kg/m²) of the Food Chain Plus (FoCus) cohort in Kiel, Germany. Participants completed a semi-quantitative food frequency questionnaire and provided blood samples. Reduced rank regression with C-reactive protein (CRP) and Interleukin 6 (IL-6) as response variables was used to derive dietary patterns. After a mean follow-up of 1.7 years, a second blood sample was obtained in a subsample of 112 individuals. Multiple regression models were used to examine the association between dietary patterns at baseline and inflammatory biomarkers at follow-up.

Results

The overall pattern characterised by high intakes of soft drinks, meat, potatoes and sauce, and low intakes of other cereals (except pasta/rice), wine, nuts, seeds, vegetarian dishes, vegetable oil, and fish was positively associated with CRP (OR 2.20; 95% CI 1.12, 4.35) and IL-6 (OR 3.14; 95% CI 1.26, 7.87) at follow-up. In men, the dietary pattern was higher in soft drinks, processed meat and low in cereals and plant-based fats. In women, the pattern was characterised by soft drinks, meat, vegetables and low in other cereals, wine, nuts, and seeds. The association between sex-specific patterns with inflammatory biomarkers was weaker for CRP.

Conclusion

We identified dietary patterns positively associated with established biomarkers of chronic low-grade inflammation.

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Title: Dietary patterns associated with inflammatory biomarkers in a Northern German population
Authors: Janett Barbaresko
Johanna Rienks
Kolade Oluwagbemigun
Gunnar Jacobs
Wolfgang Lieb
Matthias Laudes
Ute Nöthlings
Publication date: 01-06-2020
Publisher: Springer Berlin Heidelberg
Keyword: Biomarkers
Published in: European Journal of Nutrition / Issue 4/2020
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-019-02000-w

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