Top

Journal of the Association for Research in Otolaryngology

Published in:

Open Access 20-12-2023 | Benign Paroxysmal Positional Vertigo | Editorial

About the Genetic Contribution to Chronic Dizziness and Episodic Vertigo

Author: Jose A. Lopez-Escamez

Published in: Journal of the Association for Research in Otolaryngology | Issue 6/2023

Excerpt

When investigating the genetic underpinnings of any particular trait, there are two prime aspects to consider. Firstly, the condition has to demonstrate some degree of heritability, which is the proportion of phenotypic variance explained by genetic factors [1]. This can be reasonably addressed using genetic epidemiology, including familial aggregation, adoptee, and twin studies [2]. Secondly, the prevalence of the target phenotype is essential to anticipate the genetic architecture of the condition and identify causal genomic variation. Common disorders, with a prevalence > 5%, have a multiallelic (polygenic) structure with many common variants driving the association, each of them with a small effect size. Conversely, rare disorders are most often associated with few rare variants of large effect size [3]. …

Visscher PM, Medland SE, Ferreira MAR, Morley KI, Zhu G, Cornes BK et al (2006) Assumption-free estimation of heritability from genome-wide identity-by-descent sharing between full siblings. PLoS Genet 2(3):e41

Génin E (2020) Missing heritability of complex diseases: case solved? Hum Genet 139(1):103–113CrossRefPubMed

Kumar S, Gerstein M (2023) Unified views on variant impact across many diseases. Trends Genet 39(6):442–450CrossRefPubMed

El Haber N, Hill KD, Cassano AM, Paton LM, Macinnis RJ, Cui JS, Hopper JL, Wark JD (2006) Genetic and environmental influences on variation in balance performance among female twin pairs aged 21–82 years. Am J Epidemiol 164(3):246–256CrossRefPubMed

Wagner H, Melhus H, Pedersen NL, Michaëlsson K (2009) Heritability of impaired balance: a nationwide cohort study in twins. Osteoporos Int 20(4):577–583CrossRefPubMed

Skuladottir AT et al (2021) A genome-wide meta-analysis uncovers six sequence variants conferring risk of vertigo. Commun Biol 4(1):1148CrossRefPubMedPubMedCentral

Clifford RE et al (2023) Genome-wide association study of chronic dizziness in the elderly identifies loci implicating MLLT10, BPTF, LINC01224, and ROS1. J Assoc Res Otalaryngol. Epub ahead of print.

Parra-Perez AM, Lopez-Escamez JA (2023) Types of inheritance and genes associated with familial Meniere disease. J Assoc Res Otolaryngol 24(3):269–279CrossRefPubMedPubMedCentral

Uffelmann E, Huang QQ, Munung NS et al (2021) Genome-wide association studies. Nat Rev Methods Primers 1:59

10.

Lempert T, Olesen J, Furman J, Waterston J, Seemungal B, Carey J, Bisdorff A, Versino M, Evers S, Kheradmand A, Newman-Toker D (2022) Vestibular migraine: diagnostic criteria1. J Vestib Res 32(1):1–6CrossRefPubMedPubMedCentral

11.

Lopez-Escamez JA, Carey J, Chung WH, Goebel JA, Magnusson M, Mandalà M, Newman-Toker DE, Strupp M, Suzuki M, Trabalzini F, Bisdorff A; Classification Committee of the Barany Society; Japan Society for Equilibrium Research; European Academy of Otology and Neurotology (EAONO); Equilibrium Committee of the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS); Korean Balance Society (2015) Diagnostic criteria for Menière’s disease. J Vestib Res 25(1):1–7

12.

Cha YH, Golding JF, Keshavarz B, Furman J, Kim JS, Lopez-Escamez JA, Magnusson M, Yates BJ, Lawson BD (2021) Advisors: Motion sickness diagnostic criteria: consensus document of the Classification Committee of the Bárány Society. J Vestib Res 31(5):327–344CrossRefPubMedPubMedCentral

13.

Staab JP et al (2017) Diagnostic criteria for persistent postural-perceptual dizziness (PPPD): consensus document of the Committee for the Classification of Vestibular Disorders of the Bárány Society. J Vest Res 27:191–208

14.

Cha YH, Baloh RW, Cho C, Magnusson M, Song JJ, Strupp M, Wuyts F, Staab JP (2020) Mal de débarquement syndrome diagnostic criteria: consensus document of the Classification Committee of the Bárány Society. J Vestib Res 30(5):285–293CrossRefPubMedPubMedCentral

15.

Strupp M, Kim JS, Murofushi T, Straumann D, Jen JC, Rosengren SM, Della Santina CC, Kingma H (2017) Bilateral vestibulopathy: diagnostic criteria consensus document of the Classification Committee of the Bárány Society. J Vestib Res 27(4):177–189CrossRefPubMedPubMedCentral

Title: About the Genetic Contribution to Chronic Dizziness and Episodic Vertigo
Author: Jose A. Lopez-Escamez
Publication date: 20-12-2023
Publisher: Springer US
Keywords: Benign Paroxysmal Positional Vertigo
Vestibular Migraine
Published in: Journal of the Association for Research in Otolaryngology / Issue 6/2023
Print ISSN: 1525-3961
Electronic ISSN: 1438-7573
DOI: https://doi.org/10.1007/s10162-023-00921-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

About the Genetic Contribution to Chronic Dizziness and Episodic Vertigo

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 6/2023

Genome-Wide Association Study of Chronic Dizziness in the Elderly Identifies Loci Implicating MLLT10, BPTF, LINC01224, and ROS1

Speech Perception in Noise and Medial Olivocochlear Reflex: Effects of Age, Speech Stimulus, and Response-Related Variables

Review and Perspective on Brain Bases of Tinnitus

Eavesdropping on Tinnitus Using MEG: Lessons Learned and Future Perspectives

Spectral Grouping of Electrically Encoded Sound Predicts Speech-in-Noise Performance in Cochlear Implantees

Noise-Induced Hearing Threshold Shift Correlated with Body Weight and External-Ear Amplification in Chinchilla: a Preliminary Analysis