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Journal of the Association for Research in Otolaryngology

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Open Access 27-11-2023 | Research Article

Noise-Induced Hearing Threshold Shift Correlated with Body Weight and External-Ear Amplification in Chinchilla: a Preliminary Analysis

Authors: Sarah K. Grinn, Monica Trevino, Edward Lobarinas

Published in: Journal of the Association for Research in Otolaryngology | Issue 6/2023

Abstract

Background

External-ear amplification (EEA) has been shown to vary from 5–19 dB-A in large datasets of pediatric, adolescent, and adult human participants. However, variable EEA is an overlooked characteristic that likely plays a role in individual noise-induced hearing loss (NIHL) susceptibility. A noise exposure varying 5–19 dB-A translates to high-EEA individuals theoretically experiencing 3–4 times greater NIHL risk than low-EEA individuals.

Objective

The purpose of this preliminary analysis was to test the hypothesis that higher EEA is correlated with increased noise-induced threshold shift susceptibility.

Design

Nine chinchillas were exposed to 4-kHz octave-band noise at 89 dB-SPL for 24 h. Auditory brainstem response thresholds were obtained pre-exposure, 24-h post-exposure, and 4-week post-exposure. Relationships between EEA and threshold shift were analyzed.

Results

Open-ear EEA ranged 11–19 dB-SPL, and occluded-ear EEA ranged 10–21 dB-SPL. Higher occluded-ear EEA was correlated with increased NIHL susceptibility (p = 0.04), as was lower body weight (p = 0.01). Male animals exhibited more threshold shift than female animals (p = 0.02), lower body weight than female animals (p = 0.02), and higher occluded-ear EEA (male mean = 18 dB; female mean = 15 dB).

Conclusions

Taken together, increased threshold shift susceptibility was observed in the smallest animals, animals with the highest occluded-ear EEA, and in male animals (which tended to have higher occluded-ear EEA). Given the established relationship between smaller body size and higher occluded-ear EEA, these preliminary results suggest that body size (and occluded-ear EEA; a function of body size) could be a potential, underlying driver of NIHL susceptibility differences, rather than true sex differences.

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Title: Noise-Induced Hearing Threshold Shift Correlated with Body Weight and External-Ear Amplification in Chinchilla: a Preliminary Analysis
Authors: Sarah K. Grinn
Monica Trevino
Edward Lobarinas
Publication date: 27-11-2023
Publisher: Springer US
Published in: Journal of the Association for Research in Otolaryngology / Issue 6/2023
Print ISSN: 1525-3961
Electronic ISSN: 1438-7573
DOI: https://doi.org/10.1007/s10162-023-00913-2

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Noise-Induced Hearing Threshold Shift Correlated with Body Weight and External-Ear Amplification in Chinchilla: a Preliminary Analysis

Abstract

Background

Objective

Design

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Objective

Design

Results

Conclusions

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