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Published in: Abdominal Radiology 5/2016

Open Access 01-05-2016 | Pictorial Essay

Benign causes of diffusion restriction foci in the peripheral zone of the prostate: diagnosis and differential diagnosis

Authors: Nirjhor M. Bhowmik, Jinxing Yu, Ann S. Fulcher, Mary A. Turner

Published in: Abdominal Radiology | Issue 5/2016

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Abstract

Multiparametric-MRI is an important tool in the diagnosis of prostate cancer (PCa), particularly diffusion-weighted imaging for peripheral zone (PZ) cancer in the untreated prostate. However, there are many benign entities that demonstrate diffusion restriction in the PZ mimicking PCa resulting in diagnostic challenges. Fortunately, these benign entities usually have unique MR features that may help to distinguish them from PCa. The purpose of this pictorial review is to discuss benign entities with diffusion restriction in the PZ and to emphasize the key MR features of these entities that may help to differentiate them from PCa.
Literature
3.
go back to reference Coley CM, Barry MJ, Mulley AG, et al. (1997) Screening for prostate cancer. Ann Intern Med 126:480–484CrossRef Coley CM, Barry MJ, Mulley AG, et al. (1997) Screening for prostate cancer. Ann Intern Med 126:480–484CrossRef
4.
go back to reference Moul JW (2000) Prostate specific antigen only progression of prostate cancer. J Urol 163:1632–1642CrossRefPubMed Moul JW (2000) Prostate specific antigen only progression of prostate cancer. J Urol 163:1632–1642CrossRefPubMed
6.
go back to reference Vargas HA, Akin O, Franiel T, et al. (2011) Diffusion weighted endorectal MR imaging at 3 T for prostate cancer: tumor detection and assessment of aggressiveness. Radiology 259:775–784CrossRefPubMedPubMedCentral Vargas HA, Akin O, Franiel T, et al. (2011) Diffusion weighted endorectal MR imaging at 3 T for prostate cancer: tumor detection and assessment of aggressiveness. Radiology 259:775–784CrossRefPubMedPubMedCentral
7.
go back to reference Somford DM, Futterer JJ, Hambrock T, Barentsz JO (2008) Diffusion and perfusion MR imaging of the prostate. Magn Reson Imaging Clin N Am 16:685–695CrossRefPubMed Somford DM, Futterer JJ, Hambrock T, Barentsz JO (2008) Diffusion and perfusion MR imaging of the prostate. Magn Reson Imaging Clin N Am 16:685–695CrossRefPubMed
9.
go back to reference Pucar D, Shukla-Dave A, Hricak H, et al. (2005) Prostate cancer: correlation of MR imaging and MR spectroscopy with pathologic findings after radiation therapy-initial experience. Radiology 236:545–553CrossRefPubMedPubMedCentral Pucar D, Shukla-Dave A, Hricak H, et al. (2005) Prostate cancer: correlation of MR imaging and MR spectroscopy with pathologic findings after radiation therapy-initial experience. Radiology 236:545–553CrossRefPubMedPubMedCentral
10.
go back to reference Haider MA, Kwast TH, Tanguay J, et al. (2007) Combined T2-weighted and diffusion-weighted MRI for localization of prostate cancer. AJR Am J Roentgenol 189:323–328CrossRefPubMed Haider MA, Kwast TH, Tanguay J, et al. (2007) Combined T2-weighted and diffusion-weighted MRI for localization of prostate cancer. AJR Am J Roentgenol 189:323–328CrossRefPubMed
11.
go back to reference Hoeks CM, Barentsz JO, Hambrock T, et al. (2011) Prostate cancer: multiparametric MR imaging for detection, localization, and staging. Radiology 261:46–66CrossRefPubMed Hoeks CM, Barentsz JO, Hambrock T, et al. (2011) Prostate cancer: multiparametric MR imaging for detection, localization, and staging. Radiology 261:46–66CrossRefPubMed
12.
go back to reference Franiel T, Ludemann L, Rudolph B, et al. (2008) Evaluation of normal prostate tissue, chronic prostatitis, and prostate cancer by quantitative perfusion analysis using a dynamic contrast-enhanced inversion- prepared dual-contrast gradient echo sequence. Invest Radiol 43:481–487CrossRefPubMed Franiel T, Ludemann L, Rudolph B, et al. (2008) Evaluation of normal prostate tissue, chronic prostatitis, and prostate cancer by quantitative perfusion analysis using a dynamic contrast-enhanced inversion- prepared dual-contrast gradient echo sequence. Invest Radiol 43:481–487CrossRefPubMed
13.
go back to reference Shukla-Dave A, Hricak H, Eberhardt SC, et al. (2004) Chronic prostatitis: MR imaging and 1H MR spectroscopic imaging findings—initial observations. Radiology 231:717–724CrossRefPubMed Shukla-Dave A, Hricak H, Eberhardt SC, et al. (2004) Chronic prostatitis: MR imaging and 1H MR spectroscopic imaging findings—initial observations. Radiology 231:717–724CrossRefPubMed
14.
go back to reference Rosenkrantz AB, Taneja SS (2014) Radiologist, be aware: ten pitfalls that confound the interpretation of multiparametric prostate MRI. AJR Am J Roentgenol 202:109–120CrossRefPubMed Rosenkrantz AB, Taneja SS (2014) Radiologist, be aware: ten pitfalls that confound the interpretation of multiparametric prostate MRI. AJR Am J Roentgenol 202:109–120CrossRefPubMed
15.
go back to reference Park SY, Kim CK, et al. (2014) Diffusion-tensor MRI at 3T: differentiation of central gland prostate cancer from benign prostatic hyperplasia. AJR 202:254–262CrossRef Park SY, Kim CK, et al. (2014) Diffusion-tensor MRI at 3T: differentiation of central gland prostate cancer from benign prostatic hyperplasia. AJR 202:254–262CrossRef
18.
go back to reference Vargas HA, Akin O, Franiel T, et al. (2012) Normal central zone of the prostate and central zone involvement by prostate cancer: clinical and MR imaging implications. Radiology 262:894–902CrossRefPubMedPubMedCentral Vargas HA, Akin O, Franiel T, et al. (2012) Normal central zone of the prostate and central zone involvement by prostate cancer: clinical and MR imaging implications. Radiology 262:894–902CrossRefPubMedPubMedCentral
19.
go back to reference Schiebler ML, Tomaszewski JE, Bezzi M, et al. (1989) Prostatic carcinoma and benign prostatic hyperplasia: correlation of high-resolution MR and histopathologic findings. Radiology 172:131–137CrossRefPubMed Schiebler ML, Tomaszewski JE, Bezzi M, et al. (1989) Prostatic carcinoma and benign prostatic hyperplasia: correlation of high-resolution MR and histopathologic findings. Radiology 172:131–137CrossRefPubMed
20.
go back to reference Kiyoshima K, Yokomizo A, Yoshida T, et al. (2004) Anatomical features of periprostatic tissue and its surroundings: a histological analysis of 79 radical retropubic prostatectomy specimens. J Clin Oncol 34:463–468 Kiyoshima K, Yokomizo A, Yoshida T, et al. (2004) Anatomical features of periprostatic tissue and its surroundings: a histological analysis of 79 radical retropubic prostatectomy specimens. J Clin Oncol 34:463–468
21.
go back to reference White S, Hricak H, Forstner R, et al. (1995) Prostate cancer: effect of postbiopsy hemorrhage on interpretation of MR images. Radiology 195:385–390CrossRefPubMed White S, Hricak H, Forstner R, et al. (1995) Prostate cancer: effect of postbiopsy hemorrhage on interpretation of MR images. Radiology 195:385–390CrossRefPubMed
22.
go back to reference Tamada T, Sone T, Jo Y, et al. (2008) Prostate cancer: relationships between postbiopsy hemorrhage and tumor detectability at MR diagnosis. Radiology 248:531–539CrossRefPubMed Tamada T, Sone T, Jo Y, et al. (2008) Prostate cancer: relationships between postbiopsy hemorrhage and tumor detectability at MR diagnosis. Radiology 248:531–539CrossRefPubMed
23.
go back to reference Rosenkrantz AB, Kopec M, Kong X, et al. (2010) Prostate cancer vs. post-biopsy hemorrhage: diagnosis with T2- and diffusion-weighted imaging. J Magn Reson Imaging 31:1387–1394CrossRefPubMed Rosenkrantz AB, Kopec M, Kong X, et al. (2010) Prostate cancer vs. post-biopsy hemorrhage: diagnosis with T2- and diffusion-weighted imaging. J Magn Reson Imaging 31:1387–1394CrossRefPubMed
24.
go back to reference Barrett T, Vargas HA, Akin O, Goldman DA, Hricak H (2012) Value of the hemorrhage exclusion sign on T1-weighted prostate MR images for the detection of prostate cancer. Radiology 263:751–757CrossRefPubMedPubMedCentral Barrett T, Vargas HA, Akin O, Goldman DA, Hricak H (2012) Value of the hemorrhage exclusion sign on T1-weighted prostate MR images for the detection of prostate cancer. Radiology 263:751–757CrossRefPubMedPubMedCentral
25.
go back to reference Phillips ME, Kressel HY, Spritzer CE, et al. (1987) Normal prostate and adjacent structures: MR imaging at 1.5 T. Radiology 164:381–385CrossRefPubMed Phillips ME, Kressel HY, Spritzer CE, et al. (1987) Normal prostate and adjacent structures: MR imaging at 1.5 T. Radiology 164:381–385CrossRefPubMed
27.
go back to reference Nunes LW, Schiebler MS, Rauschning W, et al. (1995) The normal prostate and periprostatic structures: correlation between MR images made with an endorectal coil and cadaveric microtome sections. AJR 164:923–927CrossRefPubMed Nunes LW, Schiebler MS, Rauschning W, et al. (1995) The normal prostate and periprostatic structures: correlation between MR images made with an endorectal coil and cadaveric microtome sections. AJR 164:923–927CrossRefPubMed
28.
go back to reference Poon PY, Bronskill MJ, Poon CS, et al. (1991) Identification of the periprostatic venous plexus by MR imaging. J Comput Assist Tomogr 15:265–268CrossRefPubMed Poon PY, Bronskill MJ, Poon CS, et al. (1991) Identification of the periprostatic venous plexus by MR imaging. J Comput Assist Tomogr 15:265–268CrossRefPubMed
29.
go back to reference Tempany CM, Rahmouni AD, et al. (1991) Invasion of the neurovascular bundle by prostate cancer: evaluation with MR imaging. Radiology 181:107–112CrossRefPubMed Tempany CM, Rahmouni AD, et al. (1991) Invasion of the neurovascular bundle by prostate cancer: evaluation with MR imaging. Radiology 181:107–112CrossRefPubMed
30.
go back to reference Mohan H, Bal A, Punia RP, Bawa AS (2005) Granulomatous prostatitis: an infrequent diagnosis. Int J Urol 12:474–478CrossRefPubMed Mohan H, Bal A, Punia RP, Bawa AS (2005) Granulomatous prostatitis: an infrequent diagnosis. Int J Urol 12:474–478CrossRefPubMed
31.
go back to reference Bour L, Schull A, Delongchamps NB, et al. (2013) Multiparametric MRI features of granulomatous prostatitis and tubercular prostate abscess. Diagn Interv Imaging 94:84–90CrossRefPubMed Bour L, Schull A, Delongchamps NB, et al. (2013) Multiparametric MRI features of granulomatous prostatitis and tubercular prostate abscess. Diagn Interv Imaging 94:84–90CrossRefPubMed
32.
go back to reference Oppenheimer JR, Kahane H, Epstein JI (1997) Granulomatous prostatitis on needle biopsy. Arch Pathol Lab Med 121:724–729PubMed Oppenheimer JR, Kahane H, Epstein JI (1997) Granulomatous prostatitis on needle biopsy. Arch Pathol Lab Med 121:724–729PubMed
33.
go back to reference Gray H (1999) The unabridged gray’s anatomy. Philadelphia: Running Press Kids Gray H (1999) The unabridged gray’s anatomy. Philadelphia: Running Press Kids
Metadata
Title
Benign causes of diffusion restriction foci in the peripheral zone of the prostate: diagnosis and differential diagnosis
Authors
Nirjhor M. Bhowmik
Jinxing Yu
Ann S. Fulcher
Mary A. Turner
Publication date
01-05-2016
Publisher
Springer US
Published in
Abdominal Radiology / Issue 5/2016
Print ISSN: 2366-004X
Electronic ISSN: 2366-0058
DOI
https://doi.org/10.1007/s00261-016-0719-6

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