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Published in: Digestive Diseases and Sciences 4/2017

01-04-2017 | UNM Clinical Case Conferences

Avoiding “Rash” Conclusions: Challenge of IgA Vasculitis in Adults

Authors: S. Hu, A. Birg, M. Hovaida, M. W. Gavin, D. McCarthy

Published in: Digestive Diseases and Sciences | Issue 4/2017

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Abstract

IgA vasculitis is primarily a pediatric disease that is rarely encountered in adults. With adults, gastrointestinal manifestations are quite common, yet are nonspecific and may overlap with other diseases, particularly Crohn’s disease, which can make the diagnosis a challenging task. Treatment is controversial given the disease course is usually self-limited with few serious complications. We present a case of IgA vasculitis in an adult patient with limited extraintestinal findings illustrating the complexity of arriving at the correct diagnosis.
Literature
1.
go back to reference Hernatadt HM, Bartlett M, Kausman JY, Macgregor D, et al. Complicated Henoch–Schonlein purpura. J Paediatr Child Health. 2015;51:639–642.CrossRef Hernatadt HM, Bartlett M, Kausman JY, Macgregor D, et al. Complicated Henoch–Schonlein purpura. J Paediatr Child Health. 2015;51:639–642.CrossRef
2.
go back to reference Yong AM-Y, Lee S-X, Tay Y-K. The profile of adult onset Henoch–Schönlein purpura in an Asian population. Int J Dermatol. 2015;54:1236–1241.CrossRefPubMed Yong AM-Y, Lee S-X, Tay Y-K. The profile of adult onset Henoch–Schönlein purpura in an Asian population. Int J Dermatol. 2015;54:1236–1241.CrossRefPubMed
3.
4.
go back to reference Kang Y, Park J-S, Ha Y-J, et al. Differences in clinical manifestations and outcomes between adult and child patients with Henoch–Schönlein purpura. J Korean Med Sci. 2014;29:198–203.CrossRefPubMedPubMedCentral Kang Y, Park J-S, Ha Y-J, et al. Differences in clinical manifestations and outcomes between adult and child patients with Henoch–Schönlein purpura. J Korean Med Sci. 2014;29:198–203.CrossRefPubMedPubMedCentral
5.
go back to reference Sheth K, Bockorny M, Elaba Z, et al. Adult onset Henoch–Schönlein purpura: case report and review of literature. Conn Med. 2015;79:81–85.PubMed Sheth K, Bockorny M, Elaba Z, et al. Adult onset Henoch–Schönlein purpura: case report and review of literature. Conn Med. 2015;79:81–85.PubMed
6.
go back to reference Rigante D, Castellazzi L, Bosco A, et al. Is there a crossroad between infections, genetics, and Henoch–Schönlein purpura? Autoimmun Rev. 2013;12:1016–1021.CrossRefPubMed Rigante D, Castellazzi L, Bosco A, et al. Is there a crossroad between infections, genetics, and Henoch–Schönlein purpura? Autoimmun Rev. 2013;12:1016–1021.CrossRefPubMed
7.
go back to reference Cojocariu C, Stanciu C, Ancuta C, et al. Immunoglobulin A vasculitis complicated with Clostridium difficile infection: a rare case report and brief review of the literature. J Gastrointest Liver Dis. 2016;25:235–238. Cojocariu C, Stanciu C, Ancuta C, et al. Immunoglobulin A vasculitis complicated with Clostridium difficile infection: a rare case report and brief review of the literature. J Gastrointest Liver Dis. 2016;25:235–238.
8.
go back to reference Audemard-Verger A, Pillebout E, Guillevin L, et al. IgA vasculitis (Henoch–Shönlein purpura) in adults: diagnostic and therapeutic aspects. Autoimmun Rev. 2015;14:579–585.CrossRefPubMed Audemard-Verger A, Pillebout E, Guillevin L, et al. IgA vasculitis (Henoch–Shönlein purpura) in adults: diagnostic and therapeutic aspects. Autoimmun Rev. 2015;14:579–585.CrossRefPubMed
9.
go back to reference Sibartie V, O’Leary P, Peirce TH. Mesenteric vasculitis in adults with Henoch–Schonlein purpura: a not-so-benign condition. Iran J Med Sci. 2009;181:269–271.CrossRef Sibartie V, O’Leary P, Peirce TH. Mesenteric vasculitis in adults with Henoch–Schonlein purpura: a not-so-benign condition. Iran J Med Sci. 2009;181:269–271.CrossRef
10.
11.
go back to reference Zhang Yan, Huang Xinglan. Gastrointestinal involvement in Henoch–Schönlein purpura. Scand J Gastroenterol. 2008;43:1038–1043.CrossRefPubMed Zhang Yan, Huang Xinglan. Gastrointestinal involvement in Henoch–Schönlein purpura. Scand J Gastroenterol. 2008;43:1038–1043.CrossRefPubMed
12.
go back to reference Esaki M, Matsumoto T, Nakamura S, et al. GI involvement in Henoch–Schönlein purpura. Gastrointest Endosc. 2002;56:920–923.CrossRefPubMed Esaki M, Matsumoto T, Nakamura S, et al. GI involvement in Henoch–Schönlein purpura. Gastrointest Endosc. 2002;56:920–923.CrossRefPubMed
13.
go back to reference Nishiyama R, Nakajima N, Ogihara A, et al. Endoscope images of Schönlein–Henoch purpura. Digestion. 2008;77:236–241.CrossRefPubMed Nishiyama R, Nakajima N, Ogihara A, et al. Endoscope images of Schönlein–Henoch purpura. Digestion. 2008;77:236–241.CrossRefPubMed
14.
go back to reference Sampat HN, McAllister BP, Gaines DD, et al. Terminal ileitis as a feature of Henoch–Schönlein purpura masquerading as Crohn disease in adults. J Clin Rheumatol. 2016;22:82–85.CrossRefPubMed Sampat HN, McAllister BP, Gaines DD, et al. Terminal ileitis as a feature of Henoch–Schönlein purpura masquerading as Crohn disease in adults. J Clin Rheumatol. 2016;22:82–85.CrossRefPubMed
15.
go back to reference Hayakawa T, Imaeda H, Nakamura M, et al. Association of pseudomembranous colitis with Henoch–Schönlein purpura. J Gastroenterol. 2005;40:641–645.CrossRefPubMed Hayakawa T, Imaeda H, Nakamura M, et al. Association of pseudomembranous colitis with Henoch–Schönlein purpura. J Gastroenterol. 2005;40:641–645.CrossRefPubMed
Metadata
Title
Avoiding “Rash” Conclusions: Challenge of IgA Vasculitis in Adults
Authors
S. Hu
A. Birg
M. Hovaida
M. W. Gavin
D. McCarthy
Publication date
01-04-2017
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 4/2017
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-017-4505-2

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