Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Digestive Diseases and Sciences
Published in: Digestive Diseases and Sciences 4/2017

01-04-2017 | Paradigm Shifts In Perspectives

Development of Monoclonal Antibodies: The Dawn of mAb Rule

Author: Jonathan D. Kaunitz

Published in: Digestive Diseases and Sciences | Issue 4/2017

Login to get access

Excerpt

Underlying most major therapeutic advances are fundamental discoveries that shake scientific discourse to its core, usually generating Nobel prizes and entirely new fields of study. In this eighth installment of the series entitled “Paradigm Shifts in Perspective,” Drs. Sofia and Rubin highlight the considerable impact that therapeutic monoclonal antibodies (mAbs) have made on gastrointestinal practice. …
Literature
1.
2.
3.
Bjørneboe M, Gormsen H. Experimental studies on the role of plasma cells as antibody producers. 1942. APMIS. 2007;115:440–483.CrossRefPubMed
4.
5.
Osserman EF, Lawlor DP. Abnormal serum and urine proteins in thirty five cases of multiple myeloma, as studied by filter paper electrophoresis. Am J Med. 1955;18:462–476.CrossRefPubMed
6.
Waldenstrom J. Monoclonal and polyclonal gammopathies and the biological system of gamma globulins. Prog Allergy. 1962;6:320–348.PubMed
7.
Awdeh ZL, Askonas BA, Williamson AR. The homogeneous-gamma-G-immunoglobulin produced by mouse plasmacytoma 5563 and its subsequent heterogeneity in serum. Biochem J. 1967;102:548–553.CrossRefPubMedPubMedCentral
8.
Askonas BA, Williamson AR, Wright BE. Selection of a single antibody-forming cell clone and its propagation in syngeneic mice. Proc Natl Acad Sci USA. 1970;67:1398–1403.CrossRefPubMedPubMedCentral
9.
Köhler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature. 1975;256:495–497.CrossRefPubMed
10.
Liu JK. The history of monoclonal antibody development—progress, remaining challenges and future innovations. Ann Med Surg (Lond). 2014;3:113–116.CrossRef
11.
Smith SL. Ten years of orthoclone OKT3 (muromonab-CD3): a review. J Transpl Coord. 1996;6:109–119.CrossRefPubMed
12.
Danese S, Vuitton L, Peyrin-Biroulet L. Biologic agents for IBD: practical insights. Nat Rev Gastroenterol Hepatol. 2015;12:537–545.CrossRefPubMed
Metadata
Title
Development of Monoclonal Antibodies: The Dawn of mAb Rule
Author
Jonathan D. Kaunitz
Publication date
01-04-2017
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 4/2017
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-017-4478-1

Other articles of this Issue 4/2017

Digestive Diseases and Sciences 4/2017 Go to the issue

Original Article

Acute Liver Failure Due to Hepatitis E Virus Infection Is Associated with Better Survival than Other Etiologies in Indian Patients

Original Article

Mortality Following Catheter Drainage Versus Thoracentesis in Cirrhotic Patients with Pleural Effusion

Editorial

Psychological Comorbidity and Chronic Heartburn: Which Is the Chicken and Which Is the Egg?

Editorial

Performance Improvement: Quality Is in the Cards

Original Article

Prevalence of Psychiatric Comorbidity in Symptomatic Gastroesophageal Reflux Subgroups

Correspondence

Diagnostic Value of Small Bowel Capsule Endoscopy in Isolated Ileitis: A Methodological Mistake
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits