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Acta Neurologica Belgica

16-04-2024 | Aura | Original article

Alteration in the expression of long non-coding RNAs in the circulation of migraineurs

Authors: Mohammad Taheri, Reyhaneh Eghtedarian, Solat Eslami, Bashdar Mahmud Hussen, Soudeh Ghafouri-Fard, Seyed Abdulmajid Ayatollahi

Published in: Acta Neurologica Belgica

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Abstract

Background

Current studies have shown emerging roles of lncRNAs in the pathobiology of neuropathic pain and migraine.

Methods

We have chosen five lncRNAs, namely, PVT1, DSCAM-AS, MEG3, LINC-ROR, and SPRY4-IT1 for assessment of their expression in the circulation of migraineurs.

Results

Expressions of PVT1 and MEG3 were higher in total migraineurs and both subgroups compared with controls (P < 0.0001). Meanwhile, expression of both lncRNA was higher in migraineurs with aura versus migraineurs without aura (P value < 0.0001 and = 0.01, respectively). Expression of DSCAM-AS1 was not different between any groups of patients compared with controls. Expression of LINC-ROR was elevated in total patients and patients with aura compared with controls (P value = 0.0002 and < 0.0001, respectively). It was also over-expressed in migraineurs with aura vs. migraineurs without aura (P = 0.01). Finally, expression of SPRY4-IT1 was higher in total patients and patients without aura compared with migraine-free persons (P values < 0.0001). Expressions of five mentioned lncRNAs were correlated in almost all study groups. In patients without aura, correlations were significant only for two pairs (SPRY4-IT1/PVT1 and SPRY4-IT1/DSCAM-AS1). PVT1 and MEG3 had the appropriate AUC, sensitivity and specificity values for separation of total migraineurs and both groups of patients from controls. The highest AUC value was reported for PVT1 in separation of migraineurs with aura from healthy controls (AUC = 0.98).

Conclusion

Cumulatively, our study shows evidence for deregulation of lncRNAs in migraineurs.
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Metadata
Title
Alteration in the expression of long non-coding RNAs in the circulation of migraineurs
Authors
Mohammad Taheri
Reyhaneh Eghtedarian
Solat Eslami
Bashdar Mahmud Hussen
Soudeh Ghafouri-Fard
Seyed Abdulmajid Ayatollahi
Publication date
16-04-2024
Publisher
Springer International Publishing
Published in
Acta Neurologica Belgica
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI
https://doi.org/10.1007/s13760-024-02513-0