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01-10-2021 | Astrocytoma | Original Article

Revisiting vimentin: a negative surrogate marker of molecularly defined oligodendroglioma in adult type diffuse glioma

Authors: Seong-Ik Kim, Kwanghoon Lee, Jeongmo Bae, Sungyoung Lee, Hongseok Yun, Chul-Kee Park, Seung Hong Choi, Christopher Alec Maquiling, Sung-Hye Park, Jae-Kyung Won

Published in: Brain Tumor Pathology | Issue 4/2021

Abstract

Vimentin is a marker of epithelial-mesenchymal transformation and indicates poor prognosis in various cancers, but its role in diffuse gliomas remains unknown. We investigated the vimentin expression of diffuse gliomas according to the upcoming 2021 WHO classification, its variations due to mutational status, and its prognostic effects. We analyzed vimentin immunohistochemistry in 315 gliomas: a test set (n = 164) and a validation set (n = 151). RNA-seq and mutational information from The Cancer Genome Atlas (TCGA, n = 422) were also used for validation. Vimentin was diffusely positive in astrocytic tumors but negative in oligodendroglial tumors (ODGs) and its expression was significantly higher in isocitrate dehydrogenase (IDH) wild-type tumors. High vimentin expression was correlated with poor prognosis (hazard ratio [HR]: 5.99), but it was dependent on the new WHO grade which reflects both histologic features and genetics (HR: 1.28). Using the significant difference in vimentin expression between ODGs and astrocytic tumors, the positive and negative predictive values of the vimentin-based diagnosis for ODGs were 93.5% and 97.8% in the validation set. Along with additional alpha-thalassemia/mental retardation, X-linked (ATRX) immunohistostaining, the values were 98.3% and 97.8%, respectively. Vimentin is a useful ancillary marker for identifying ODGs when combined with routine histochemistry markers.

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Title: Revisiting vimentin: a negative surrogate marker of molecularly defined oligodendroglioma in adult type diffuse glioma
Authors: Seong-Ik Kim
Kwanghoon Lee
Jeongmo Bae
Sungyoung Lee
Hongseok Yun
Chul-Kee Park
Seung Hong Choi
Christopher Alec Maquiling
Sung-Hye Park
Jae-Kyung Won
Publication date: 01-10-2021
Publisher: Springer Singapore
Keywords: Astrocytoma
Glioma
Glioma
Astrocytoma
Astrocytoma
Oligodendroglioma
Glioma
Published in: Brain Tumor Pathology / Issue 4/2021
Print ISSN: 1433-7398
Electronic ISSN: 1861-387X
DOI: https://doi.org/10.1007/s10014-021-00411-4

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Revisiting vimentin: a negative surrogate marker of molecularly defined oligodendroglioma in adult type diffuse glioma

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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