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11-04-2024 Respiratory Medicine News

Oral corticosteroids reduce wheeze severity in preschoolers

Children with preschool wheeze experience a significantly greater reduction in wheeze severity 4 hours after treatment with the oral corticosteroid prednisolone versus placebo.

Editor's Choice

Type 2 inflammation worsens lung function decline

07-03-2024 Respiratory Medicine News

The presence of type 2 inflammation is associated with accelerated lung function decline in people with chronic airway disease.

Machine learning approaches to predict asthma exacerbations

Open Access Bronchial Asthma Review

The use of AI and ML to predict asthma exacerbations is rapidly evolving. The review authors provide a snapshot of the existing scientific evidence and propose potential avenues for future applications.

Predictors for clinical remission on biologic therapy characterized for severe asthma

03-11-2023 Bronchial Asthma News

Researchers have defined clinical remission as a biologic treatment goal in patients with severe asthma and identified those patients most likely to achieve it.

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Current Reviews

Eosinophilic granulomatosis with polyangiitis and its association with montelukast: a case-based review

Churg-Strauss Syndrome CASE BASED REVIEW

The association between the use of certain medications (including sulfonamides, hydralazine, and procainamide) and the occurrence of drug-induced lupus or hepatitis is well established. More recently, cases of immune-related adverse events ranging …

Prenatal Exposure to Air Pollutants Associated with Allergic Diseases in Children: Which Pollutant, When Exposure, and What Disease? A Systematic Review and Meta-analysis

This systematic review aims to identify the association between prenatal exposure to air pollutants and allergic diseases in children, focusing on specific pollutants, timing of exposure, and associated diseases. We searched PubMed, Scopus, and …

Fungal Sensitization and Human Allergic Disease

Hypersensitivity reactions to fungi have been implicated in a wide range of human disease, with exposures occurring indoors and outdoors [ 1 ]. Allergenic extracts are available for a minority of fungi implicated in human disease. For those fungi …

Outcomes of Extracorporeal Life Support (ECLS) in Acute Severe Asthma: A Narrative Review

Open Access ECMO REVIEW: EXTRACORPOREAL LIFE SUPPORT (ECLS) IN ACUTE SEVERE ASTHMA

Status asthmaticus/acute severe asthma (ASA) is characterized by severe expiratory air flow limitation leading to hypercapnic and hypoxic respiratory failure and carries a mortality rate as high as 7% despite mechanical ventilation [ 1 ].

Further Reading

Airway and Systemic Immunoglobulin Profiling and Immune Response in Adult Asthma

Open Access Bronchial Asthma RESEARCH

Asthma prevalence has seen a staggering rise with disease burden reaching epidemic proportions in the western world [ 1 , 2 ]. 3–10% of asthmatics have severe asthma where symptoms remain poorly controlled despite optimal treatment with inhaled …

Effect of fractional exhaled nitric oxide (FENO)-based asthma management during pregnancy versus usual care on infant development, temperament, sensory function and autism signs

Open Access Bronchial Asthma RESEARCH

Asthma during pregnancy is associated with a range of adverse perinatal outcomes. It is also linked to increased rates of neurodevelopmental conditions in the offspring. We aimed to assess whether fractional exhaled nitric oxide (FENO)-based …

Heat-Induced Secretion of Heat Shock Proteins 70 and 90 Does not Affect the Expression of the Glucocorticoid Receptor in Primary Airway Cells in COPD

Chronic obstructive pulmonary disease (COPD) is a clinical syndrome resulting from a complex, cumulative and dynamic gene-environment interaction over lifetime [ 1 ]. The disease cannot be cured, and only a limited symptom control can be achieved [ …2

Pharmacological Basis of Differences in Dose Response, Dose Equivalence, and Duration of Action of Inhaled Corticosteroids

Open Access Ciclesonide Original Research

Asthma treatment guidelines and the Global Initiative for Asthma strategy document classify inhaled corticosteroid (ICS) regimens via low-, medium-, and high-dose categories [ 1 , 2 ], often with reference to the now discontinued beclomethasone …