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Respiratory Medicine Obstructive Lung Diseases

Obstructive Lung Diseases

Should we think twice when prescribing PPIs?

Proton pump inhibitors are a common and effective treatment for acid-related disorders, but reported adverse effects demand consideration.

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Editor's Choice

Support for high-flow nasal oxygen from RENOVATE trial

High-flow nasal oxygen is noninferior to noninvasive ventilation for preventing endotracheal intubation and death in patients with different causes of acute respiratory failure.

Tezepelumab fails to reduce severe COPD exacerbations

Treatment with the monoclonal antibody tezepelumab does not significantly reduce the annualized rate of moderate or severe chronic obstructive pulmonary disease exacerbations.

Benralizumab best for treating acute eosinophilic exacerbations

Benralizumab significantly reduces treatment failure rates and improves symptoms of eosinophilic exacerbations versus prednisolone in people with asthma or chronic obstructive pulmonary disease.

Clinical remission possible for severe asthma

Clinical remission is a realistic treatment goal for a minority of people with severe asthma treated with biologics.

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Keynote webinar | Spotlight on medication adherence

Medication non-adherence is a major barrier to effective healthcare delivery; half of all patients do not follow their doctor’s recommendations or treatment plan.

Our experts explain the fundamentals with a practical discussion of how to manage non-adherence in two common scenarios: hypertension and asthma control.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
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Video
SPONSORED

Targeting COPD with type 2 inflammation: emerging biologic landscape

1.5 European CME credits (ECMEC®s)

Watch an insightful session tailored for pulmonologists and healthcare professionals eager to enhance their understanding of COPD and the latest advances in biologic therapies.

Sponsored by:
  • Sanofi
Developed by: Springer Healthcare
Watch now
Video

Case Studies

Tracheal stenosis misdiagnosed as asthma

This case highlights that tracheal stenosis should be considered as a differential diagnosis in children presenting with the signs and symptoms of respiratory distress, particularly if the patient has a history of intubation.

Remission of eosinophilic esophagitis in an elderly patient treated with benralizumab

A case of EoE complicated by bronchial asthma in an elderly patient. The EoE did not respond to conventional therapy, but improved rapidly after benralizumab was introduced and did not recur after it was discontinued.

Superior vena cava syndrome induced by COPD

Superior vena cava (SVC) syndrome occurs when the SVC is either partially or completely obstructed. In this case of an elderly patient with dyspnea, a thoracic CT showed SVC caused by lung hyperinflation due to chronic obstructive pulmonary disease. 

Current Reviews

Efficacy of Biologics in Reducing Exacerbations Requiring Hospitalization or an Emergency Department Visit in Patients with Moderate or Severe, Uncontrolled Asthma

Severe asthma is associated with increased mortality, morbidity, and healthcare resource utilization [ 1 – 3 ]. Furthermore, direct medical costs for treatment and hospitalization associated with severe, uncontrolled asthma are three times greater …

Appraisal of β-Blocker Use in Patients with Cardiovascular Disease and Chronic Obstructive Pulmonary Disease

β-blockers are a fundamental component of cardiovascular disease (CVD) management, while β2-agonists are used to treat chronic obstructive pulmonary disease (COPD). Current guidelines recommend that these conditions be treated as usual, even when …

PI3K Inhibitors as Potential Therapeutic Agents for the Treatment of COPD with Associated Atherosclerosis

Chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) share a complex and multifactorial relationship characterized by overlapping risk factors, systemic inflammation, and intertwined pathophysiological mechanisms, with …

Monoclonal Antibodies for the Treatment of Chronic Obstructive Pulmonary Disease

Chronic obstructive pulmonary disease (COPD) is a common and complex disease characterized by persistent airflow limitation and the presence of exacerbations, resulting in significant morbidity and mortality. Although the pathogenesis of COPD is …

CME & eLearning

SPONSORED

Webinar

1.5 European CME credits (ECMEC®s)

Enhance your understanding of COPD with type 2 inflammation and learn about the evolving treatment landscape, in this webinar tailored for pulmonologists and healthcare professionals with an interest in respiratory medicine.

Sponsored by:
  • Sanofi
Developed by: Springer Healthcare

Infographic

This expert-led infographic explains how to recognize and manage COPD exacerbations and explores the impact of these exacerbations at the patient and physician level.

Supported by:
  • Sanofi and Regeneron
Developed by: Springer Healthcare

Further Reading

Predictive value of modified frailty index-5 to major complications after videothoracoscopic pulmonary resections

Although minimally invasive methods have become widespread, pulmonary resections due to lung cancer continue to be an important cause of postoperative morbidity. Herein, we have investigated the predicting efficacy of modified frailty index-5 …

Intranasal Immunotherapy with Allergen-Loaded Extracellular Vesicles from Mast Cells Alleviates Allergic Asthma Inflammation in a Murine Model

Allergen immunotherapy (AIT) is the only treatment that can alter the course of allergic diseases by inducing immune tolerance through long-term, repeated low-dose allergen exposure. Nonetheless, AIT persistently faces challenges necessitating …

Inaccurate and misleading meta-analysis of E-cigarettes and population-based diseases

A random-effects meta-analysis by Glantz et al. recently concluded that the odds of several diseases among current e-cigarette users and smokers were similar. This report details serious deficiencies. We used descriptive analysis methods to assess …

Effect of CPAP therapy on vitamin D status in patients with obstructive sleep apnea and chronic obstructive pulmonary disease overlap syndrome

Overlap syndrome (OS) is defined as the concomitant presence of apneas and hypopneas during sleep along with chronic obstructive pulmonary disease (COPD) in the same patient [ 1 ]. Although it is unclear whether each disorder increases the …

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