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World Journal of Surgical Oncology

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Open Access 01-12-2016 | Research

Associations of DNMT3B −149C>T and −2437T>A polymorphisms and lung cancer risk in Chinese population

Authors: Min Gao, Daqiang He, Fanji Meng, Jianing Li, Yan Shen

Published in: World Journal of Surgical Oncology | Issue 1/2016

Abstract

Background

DNMT3B polymorphisms are associated with the susceptibility of lung cancer. DNMT3B −2437T>A is a novel polymorphism, and its influence on the risk of lung cancer in Chinese was investigated in this study. In addition, effect of DNMT3B −149C>T polymorphism on lung cancer was also explored.

Methods

Genotyping in subjects were performed by PCR-RFLP. Haplotype frequencies were estimated by estimating haplotype software. Adjusted odds ratios (ORs) with 95% confidence intervals (CIs) were calculated by unconditional logistic regression analysis.

Results

Neither of the two polymorphisms was correlated with lung cancer (−149C>T: CT+TT vs CC: OR = 0.78, 95%CI, 0.57 to 1.05, P = 0.361; −2437T>A: AT+AA vs TT: OR = 0.99, 95%CI, 0.74 to 1.33, P = 0.168). In stratification analysis, T-allele carrier genotype of −149C>T polymorphism resulted in a reduced lung cancer risk at stage II, compared with CC (OR = 0.46, 95%CI, 0.28 to 0.77, P = 0.023). In haplotype analysis, when −149C/−2437T was used as reference, the other combined genotypes of the two polymorphisms had no significant effect on lung cancer risk (P > 0.05).

Conclusions

The two DNMT3B polymorphisms are not correlated with lung cancer risk among Chinese population nor the haplotype of them.

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Title: Associations of DNMT3B −149C>T and −2437T>A polymorphisms and lung cancer risk in Chinese population
Authors: Min Gao
Daqiang He
Fanji Meng
Jianing Li
Yan Shen
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2016
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/s12957-016-1052-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Associations of DNMT3B −149C>T and −2437T>A polymorphisms and lung cancer risk in Chinese population

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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