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World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2016

Open Access 01-12-2016 | Case report

Traumatic neuroma of the superficial peroneal nerve in a patient: a case report and review of the literature

Authors: Jian Kang, Pinglin Yang, Quanjin Zang, Xijing He

Published in: World Journal of Surgical Oncology | Issue 1/2016

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Abstract

Background

Traumatic neuromas are rare benign tumors, which are common in trauma or post-operation and accompanied with obvious symptoms of pain. This study will show the superficial peroneal nerve neuroma occurring after resection of hemangioma.

Case presentation

A 44-year-old male had an operation of the right leg cavernous hemangioma resection in 1995. Half a year after the operation, pain around the wound appeared and gradually aggravated. The patient had the lesion exploration resection in 2013, and the pathological result showed traumatic neuroma. Within half a year of the second operation, severe pain showed up again, so neuroma resection proceeded in May 2015. The postoperative pathological and immunohistochemical results showed traumatic neuroma. According to the postoperative follow-up, there were no symptoms of pain appearing again.

Literature review

The pain is obvious, and B ultrasonography is the most efficient way to find neuromas. Both conservative and operative therapy have their advantages and disadvantages.

Conclusions

There remain many unanswered questions in relation to the treatment of traumatic neuromas, and further research is required, although we have already had adequate understanding of traumatic neuromas.
Literature
1.
Li Q, Gao EL, Yang YL, et al. Traumatic neuroma in a patient with breast cancer after mastectomy: a case report and review of the literature. World J Surg Oncol. 2012;10:35.CrossRefPubMedPubMedCentral
2.
3.
Hoverson KR, Sasaki GT, Wohltmann WE. Traumatic neuroma of the penis. Dermatol Online J. 2014;20(1):21252.PubMed
4.
Allen KP, Hatanpaa KJ, Lemeshev Y, et al. Intratemporal traumatic neuromas of the facial nerve: evidence for multiple etiologies. Otol Neurotol. 2014;35(2):e69–72.CrossRefPubMed
5.
Lee EJ, Calcaterra TC, Zuckerbraun L. Traumatic neuromas of the head and neck. Ear Nose Throat J. 1998;77(8):670–4. 676.PubMed
6.
Rainsbury JW, Whiteside OJ, Bottrill ID. Traumatic facial nerve neuroma following mastoid surgery: a case report and literature review. J Laryngol Otol. 2007;121(6):601–5.CrossRefPubMed
7.
Yabuuchi H, Kuroiwa T, Fukuya T, et al. Traumatic neuroma and recurrent lymphadenopathy after neck dissection: comparison of radiologic features. Radiology. 2004;233(2):523–9.CrossRefPubMed
8.
Provost N, Bonaldi VM, Sarazin L, et al. Amputation stump neuroma: ultrasound features. J Clin Ultrasound. 1997;25(2):85–9.CrossRefPubMed
9.
Zochodne DW, Theriault M, Sharkey KA, et al. Peptides and neuromas: calcitonin gene-related peptide, substance P, and mast cells in a mechanosensitive human sural neuroma. Muscle Nerve. 1997;20(7):875–80.CrossRefPubMed
10.
Ashkar L, Omeroglu A, Halwani F, et al. Post-traumatic neuroma following breast surgery. Breast J. 2013;19(6):671–2.CrossRefPubMed
11.
Koch H, Haas F, Hubmer M, et al. Treatment of painful neuroma by resection and nerve stump transplantation into a vein. Ann Plast Surg. 2003;51(1):45–50.CrossRefPubMed
12.
Thomas AJ, Bull MJ, Howard AC, et al. Peri operative ultrasound guided needle localisation of amputation stump neuroma. Injury. 1999;30(10):689–91.CrossRefPubMed
13.
Fisher GT, Boswick Jr JA. Neuroma formation following digital amputations. J Trauma. 1983;23(2):136–42.CrossRefPubMed
14.
15.
Lai J, Porreca F, Hunter JC, et al. Voltage-gated sodium channels and hyperalgesia. Annu Rev Pharmacol Toxicol. 2004;44:371–97.CrossRefPubMed
16.
Gold MS, Weinreich D, Kim CS, et al. Redistribution of Na(V)1.8 in uninjured axons enables neuropathic pain. J Neurosci. 2003;23(1):158–66.PubMed
17.
Nennesmo I, Reinholt F. Mast cells in nerve end neuromas of mice. Neurosci Lett. 1986;69(3):296–301.CrossRefPubMed
18.
Dawson LF, Phillips JK, Finch PM, et al. Expression of alpha1-adrenoceptors on peripheral nociceptive neurons. Neuroscience. 2011;175:300–14.CrossRefPubMed
19.
Balkowiec-Iskra E, Vermehren-Schmaedick A, Balkowiec A. Tumor necrosis factor-alpha increases brain-derived neurotrophic factor expression in trigeminal ganglion neurons in an activity-dependent manner. Neuroscience. 2011;180:322–33.CrossRefPubMedPubMedCentral
20.
21.
Hagenacker T, Ledwig D, Busselberg D. Feedback mechanisms in the regulation of intracellular calcium ([Ca2+]i) in the peripheral nociceptive system: role of TRPV-1 and pain related receptors. Cell Calcium. 2008;43(3):215–27.CrossRefPubMed
22.
23.
Stokvis A, Coert JH, van Neck JW. Insufficient pain relief after surgical neuroma treatment: prognostic factors and central sensitisation. J Plast Reconstr Aesthet Surg. 2010;63(9):1538–43.CrossRefPubMed
24.
Li CY, Song YH, Higuera ES, et al. Spinal dorsal horn calcium channel alpha2delta-1 subunit upregulation contributes to peripheral nerve injury-induced tactile allodynia. J Neurosci. 2004;24(39):8494–9.CrossRefPubMedPubMedCentral
25.
Flor H. Phantom-limb pain: characteristics, causes, and treatment. Lancet Neurol. 2002;1(3):182–9.CrossRefPubMed
26.
Sturm V, Kroger M, Penzholz H. Problems of peripheral nerve surgery in amputation stump pain and phantom limbs. Chirurg. 1975;46(9):389–91.PubMed
27.
28.
Fornage BD. Peripheral nerves of the extremities: imaging with US. Radiology. 1988;167(1):179–82.CrossRefPubMed
29.
Hughes DG, Wilson DJ. Ultrasound appearances of peripheral nerve tumours. Br J Radiol. 1986;59(706):1041–3.CrossRefPubMed
30.
Reuter KL, Raptopoulos V, DeGirolami U, et al. Ultrasonography of a plexiform neurofibroma of the popliteal fossa. J Ultrasound Med. 1982;1(5):209–11.PubMed
31.
Gruber H, Glodny B, Kopf H, et al. Practical experience with sonographically guided phenol instillation of stump neuroma: predictors of effects, success, and outcome. AJR Am J Roentgenol. 2008;190(5):1263–9.CrossRefPubMed
32.
Chabal C, Jacobson L, Russell LC, et al. Pain response to perineuromal injection of normal saline, epinephrine, and lidocaine in humans. Pain. 1992;49(1):9–12.CrossRefPubMed
33.
Dworkin RH, O’Connor AB, Audette J, et al. Recommendations for the pharmacological management of neuropathic pain: an overview and literature update. Mayo Clin Proc. 2010;85(3 Suppl):S3–14.CrossRefPubMedPubMedCentral
34.
Dooley DJ, Taylor CP, Donevan S, et al. Ca2+ channel alpha2delta ligands: novel modulators of neurotransmission. Trends Pharmacol Sci. 2007;28(2):75–82.CrossRefPubMed
35.
Greenfield J, Rea Jr J, Ilfeld FW. Morton’s interdigital neuroma. Indications for treatment by local injections versus surgery. Clin Orthop Relat Res. 1984;185:142–4.PubMed
36.
Hughes RJ, Ali K, Jones H, et al. Treatment of Morton’s neuroma with alcohol injection under sonographic guidance: follow-up of 101 cases. AJR Am J Roentgenol. 2007;188(6):1535–9.CrossRefPubMed
37.
Leung A, Fallah A, Shukla S. Transcutaneous magnetic stimulation (TMS) in alleviating post-traumatic peripheral neuropathic pain states: a case series. Pain Med. 2014;15(7):1196–9.CrossRefPubMed
38.
Dahl E, Cohen SP. Perineural injection of etanercept as a treatment for postamputation pain. Clin J Pain. 2008;24(2):172–5.CrossRefPubMed
39.
Restrepo-Garces CE, Marinov A, McHardy P, et al. Pulsed radiofrequency under ultrasound guidance for persistent stump-neuroma pain. Pain Pract. 2011;11(1):98–102.CrossRefPubMed
40.
Guse DM, Moran SL. Outcomes of the surgical treatment of peripheral neuromas of the hand and forearm: a 25-year comparative outcome study. Ann Plast Surg. 2013;71(6):654–8.CrossRefPubMed
41.
Metadata
Title
Traumatic neuroma of the superficial peroneal nerve in a patient: a case report and review of the literature
Authors
Jian Kang
Pinglin Yang
Quanjin Zang
Xijing He
Publication date
01-12-2016
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2016
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/s12957-016-0990-6

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