Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
BMC Medical Genetics
Published in: BMC Medical Genetics 1/2014

Open Access 01-12-2014 | Research article

Associations between variants on ADIPOQ and ADIPOR1 with colorectal cancer risk: a chinese case-control study and updated meta-analysis

Authors: Yiyi Ou, Peizhan Chen, Ziyuan Zhou, Chenglin Li, Jinyi Liu, Kazuo Tajima, Junsheng Guo, Jia Cao, Hui Wang

Published in: BMC Medical Genetics | Issue 1/2014

Login to get access

Abstract

Background

Epidemiological studies have suggested that variants on adiponectin (ADIPOQ) and its receptor ADIPOR1 (adiponectin receptor 1) are associated with colorectal cancer (CRC) risk; however, the results were inconclusive. The aim of the study was to evaluate the associations between the variants on ADIPOQ and ADIPOR1 and the CRC risk with a hospital-based case-control study in the Chinese population along with meta-analysis of available epidemiological studies.

Methods

With a hospital-based case-control study of 341 cases and 727 controls, the associations between the common variants on ADIPOQ (rs266729, rs822395, rs2241766 and rs1501299) and ADIPOR1 (rs1342387 and rs12733285) and CRC susceptibility were evaluated. Meta-analysis of the published epidemiological studies was performed to investigate the associations between the variants and CRC risk.

Results

For the population study, we found that variant rs1342387 of ADIPOR1 was associated with a reduced risk for CRC [adjusted odds ratio (OR) = 0.74, 95% confidential intervals (95% CI) = 0.57-0.97; CT/TT vs. CC]. The meta-analysis also suggested a significant association for rs1342387 and CRC risk; the pooled OR was 0.79 (95% CI = 0.66-0.95) for the CT/TT carriers compared to CC homozygotes under the random-effects model (Q = 8.06, df = 4, P = 0.089; I2 = 50.4%). The case-control study found no significant association for variants rs266729, rs822395, rs2241766, and rs1501299 on ADIPOQ or variant rs12733285 on ADIPOR1 and CRC susceptibility, which were consistent with results from the meta-analysis studies.

Conclusions

These data suggested that variant rs1342387 on ADIPOR1 may be a novel CRC susceptibility factor.
Appendix
Available only for authorised users
Literature
1.
Siddiqui AA: Metabolic syndrome and its association with colorectal cancer: a review. Am J Med Sci. 2011, 341: 227-231. 10.1097/MAJ.0b013e3181df9055.CrossRefPubMed
2.
Tsai CJ, Giovannucci EL: Hyperinsulinemia, Insulin Resistance, Vitamin D, and Colorectal Cancer Among Whites and African Americans. Dig Dis Sci. 2012, 57: 2497-503. 10.1007/s10620-012-2198-0.CrossRefPubMed
3.
Esteve E, Ricart W, Fernandez-Real JM: Adipocytokines and insulin resistance: the possible role of lipocalin-2, retinol binding protein-4, and adiponectin. Diabetes Care. 2009, 32 (Suppl 2): S362-367. 10.2337/dc09-S340.CrossRefPubMedPubMedCentral
4.
Wei EK, Giovannucci E, Fuchs CS, Willett WC, Mantzoros CS: Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study. J Natl Cancer Inst. 2005, 97: 1688-1694. 10.1093/jnci/dji376.CrossRefPubMed
5.
Yoon MJ, Lee GY, Chung JJ, Ahn YH, Hong SH, Kim JB: Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha. Diabetes. 2006, 55: 2562-2570. 10.2337/db05-1322.CrossRefPubMed
6.
Rasmussen MS, Lihn AS, Pedersen SB, Bruun JM, Rasmussen M, Richelsen B: Adiponectin receptors in human adipose tissue: effects of obesity, weight loss, and fat depots. Obesity (Silver Spring). 2006, 14: 28-35. 10.1038/oby.2006.5.CrossRef
7.
Fujisawa T, Endo H, Tomimoto A, Sugiyama M, Takahashi H, Saito S, Inamori M, Nakajima N, Watanabe M, Kubota N, Yamauchi T, Kadowaki T, Wada K, Nakagama H, Nakajima A: Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition. Gut. 2008, 57: 1531-1538. 10.1136/gut.2008.159293.CrossRefPubMedPubMedCentral
8.
Nishihara T, Baba M, Matsuda M, Inoue M, Nishizawa Y, Fukuhara A, Araki H, Kihara S, Funahashi T, Tamura S, Hayashi N, Iishi H, Shimomura I: Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by azoxymethane in mice. World J Gastroenterol. 2008, 14: 6473-6480. 10.3748/wjg.14.6473.CrossRefPubMedPubMedCentral
9.
Kaklamani VG, Wisinski KB, Sadim M, Gulden C, Do A, Offit K, Baron JA, Ahsan H, Mantzoros C, Pasche B: Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk. JAMA. 2008, 300: 1523-1531. 10.1001/jama.300.13.1523.CrossRefPubMedPubMedCentral
10.
Pechlivanis S, Bermejo JL, Pardini B, Naccarati A, Vodickova L, Novotny J, Hemminki K, Vodicka P, Forsti A: Genetic variation in adipokine genes and risk of colorectal cancer. Eur J Endocrinol. 2009, 160: 933-940. 10.1530/EJE-09-0039.CrossRefPubMed
11.
12.
He B, Pan Y, Zhang Y, Bao Q, Chen L, Nie Z, Gu L, Xu Y, Wang S: Effects of genetic variations in the adiponectin pathway genes on the risk of colorectal cancer in the Chinese population. BMC Med Genet. 2011, 12: 94-10.1186/1471-2350-12-94.CrossRefPubMedPubMedCentral
13.
Liu L, Zhong R, Wei S, Yin JY, Xiang H, Zou L, Chen W, Chen JG, Zheng XW, Huang LJ, Zhu BB, Chen Q, Duan SY, Rui R, Yang BF, Sun JW, Xie DS, Xu YH, Miao XP, Nie SF: Interactions between Genetic Variants in the Adiponectin, Adiponectin Receptor 1 and Environmental Factors on the Risk of Colorectal Cancer. PLoS One. 2011, 6: e27301-10.1371/journal.pone.0027301.CrossRefPubMedPubMedCentral
14.
Li M, Zhou Y, Chen P, Yang H, Yuan X, Tajima K, Cao J, Wang H: Genetic variants on chromosome 8q24 and colorectal neoplasia risk: a case-control study in China and a meta-analysis of the published literature. PLoS One. 2011, 6: e18251-10.1371/journal.pone.0018251.CrossRefPubMedPubMedCentral
15.
Wu X, Chen P, Ou Y, Liu J, Li C, Wang H, Qiang F: Association of variants on ADIPOQ and AdipoR1 and the prognosis of gastric cancer patients after gastrectomy treatment. Mol Biol Rep 2014, [Epub ahead of print].,
16.
Loibl S, von Minckwitz G, Schwedler K, Schmidt KA, Hoper D, Kaufmann M, Costa SD: Mitomycin C, 5-fluorouracil and folinic acid (Mi-Fu-Fo) as salvage chemotherapy in breast cancer patients with liver metastases and impaired hepatic function: a phase II study. Anticancer Drugs. 2004, 15: 719-724. 10.1097/01.cad.0000136692.99971.ec.CrossRefPubMed
17.
Egger M, Davey Smith G, Schneider M, Minder C: Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997, 315: 629-634. 10.1136/bmj.315.7109.629.CrossRefPubMedPubMedCentral
18.
Yang H, Zhou Y, Zhou Z, Liu J, Yuan X, Matsuo K, Takezaki T, Tajima K, Cao J: A novel polymorphism rs1329149 of CYP2E1 and a known polymorphism rs671 of ALDH2 of alcohol metabolizing enzymes are associated with colorectal cancer in a southwestern Chinese population. Cancer Epidemiol Biomarkers Prev. 2009, 18: 2522-2527. 10.1158/1055-9965.EPI-09-0398.CrossRefPubMed
19.
Carvajal-Carmona LG, Spain S, Kerr D, Houlston R, Cazier JB, Tomlinson I: Common variation at the adiponectin locus is not associated with colorectal cancer risk in the UK. Hum Mol Genet. 2009, 18: 1889-1892. 10.1093/hmg/ddp109.CrossRefPubMed
20.
Al Khaldi RM, Al Mulla F, Al Awadhi S, Kapila K, Mojiminiyi OA: Associations of single nucleotide polymorphisms in the adiponectin gene with adiponectin levels and cardio-metabolic risk factors in patients with cancer. Dis Markers. 2011, 30: 197-212. 10.1155/2011/832165.CrossRefPubMedPubMedCentral
21.
Yi N, Kaklamani VG, Pasche B: Bayesian analysis of genetic interactions in case-control studies, with application to adiponectin genes and colorectal cancer risk. Ann Hum Genet. 2011, 75: 90-104. 10.1111/j.1469-1809.2010.00605.x.CrossRefPubMed
22.
Tsilidis KK, Helzlsouer KJ, Smith MW, Grinberg V, Hoffman-Bolton J, Clipp SL, Visvanathan K, Platz EA: Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer. Cancer Causes Control. 2009, 20: 1739-1751. 10.1007/s10552-009-9427-7.CrossRefPubMedPubMedCentral
23.
Partida-Perez M, de la Luz A-MM, Peregrina-Sandoval J, Macias-Gomez N, Moreno-Ortiz J, Leal-Ugarte E, Cardenas-Meza M, Centeno-Flores M, Maciel-Gutierrez V, Cabrales E, Cervantes-Ortiz S, Gutiérrez-Angulo M: Association of LEP and ADIPOQ common variants with colorectal cancer in Mexican patients. Cancer Biomark. 2010, 7: 117-121.PubMed
24.
Al-Harithy RN, Al-Zahrani MH: The adiponectin gene, ADIPOQ, and genetic susceptibility to colon cancer. Oncol Lett. 2012, 3: 176-180.PubMed
25.
Keku TO, Vidal A, Oliver S, Hoyo C, Hall IJ, Omofoye O, McDoom M, Worley K, Galanko J, Sandler RS, Millikan R: Genetic variants in IGF-I, IGF-II, IGFBP-3, and adiponectin genes and colon cancer risk in African Americans and Whites. Cancer Causes Control. 2012, 23: 1127-38. 10.1007/s10552-012-9981-2.CrossRefPubMedPubMedCentral
26.
Hu X, Yuan P, Yan J, Feng F, Li X, Liu W, Yang Y: Gene Polymorphisms of +45 T > G, -866G > A, and Ala54Thr on the Risk of Colorectal Cancer: A Matched Case-Control Study. PLoS One. 2013, 8: e67275-10.1371/journal.pone.0067275.CrossRefPubMedPubMedCentral
27.
Qi L, Doria A, Giorgi E, Hu FB: Variations in adiponectin receptor genes and susceptibility to type 2 diabetes in women: a tagging-single nucleotide polymorphism haplotype analysis. Diabetes. 2007, 56: 1586-91. 10.2337/db06-1447.CrossRefPubMed
28.
Siitonen N, Pulkkinen L, Mager U, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M: Association of sequence variations in the gene encoding adiponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish Diabetes Prevention Study. Diabetologia. 2006, 49: 1795-1805. 10.1007/s00125-006-0291-7.CrossRefPubMed
29.
Damcott CM, Ott SH, Pollin TI, Reinhart LJ, Wang J, O'Connell JR, Mitchell BD, Shuldiner AR: Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish. Diabetes. 2005, 54: 2245-2250. 10.2337/diabetes.54.7.2245.CrossRefPubMed
30.
Crimmins NA, Martin LJ: Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance. Obes Rev. 2007, 8: 419-423. 10.1111/j.1467-789X.2007.00348.x.CrossRefPubMed
31.
Ong KL, Li M, Tso AW, Xu A, Cherny SS, Sham PC, Tse HF, Lam TH, Cheung BM, Lam KS: Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese. Eur J Endocrinol. 2010, 163: 251-257. 10.1530/EJE-10-0251.CrossRefPubMed
32.
Persson J, Lindberg K, Gustafsson TP, Eriksson P, Paulsson-Berne G, Lundman P: Low plasma adiponectin concentration is associated with myocardial infarction in young individuals. J Intern Med. 2010, 268: 194-205. 10.1111/j.1365-2796.2010.02247.x.CrossRefPubMed
33.
Prior SL, Gable DR, Cooper JA, Bain SC, Hurel SJ, Humphries SE, Stephens JW: Association between the adiponectin promoter rs266729 gene variant and oxidative stress in patients with diabetes mellitus. Eur Heart J. 2009, 30: 1263-1269. 10.1093/eurheartj/ehp090.CrossRefPubMed
34.
Han LY, Wu QH, Jiao ML, Hao YH, Liang LB, Gao LJ, Legge DG, Quan H, Zhao MM, Ning N, Kang Z, Sun H: Associations between single-nucleotide polymorphisms (+45 T > G, +276G > T, -11377C > G, -11391G > A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysis. Diabetologia. 2011, 54 (9): 2303-2314. 10.1007/s00125-011-2202-9.CrossRefPubMed
35.
Zhao T, Zhao J: Genetic effects of adiponectin on blood lipids and blood pressure. Clin Endocrinol (Oxf). 2011, 74: 214-222. 10.1111/j.1365-2265.2010.03902.x.CrossRef
36.
Pischon T, Pai JK, Manson JE, Hu FB, Rexrode KM, Hunter D, Rimm EB: Single nucleotide polymorphisms at the adiponectin locus and risk of coronary heart disease in men and women. Obesity (Silver Spring). 2007, 15: 2051-2060. 10.1038/oby.2007.244.CrossRef
37.
Kyriakou T, Collins LJ, Spencer-Jones NJ, Malcolm C, Wang X, Snieder H, Swaminathan R, Burling KA, Hart DJ, Spector TD, O'Dell SD: Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity. J Hum Genet. 2008, 53: 718-727. 10.1007/s10038-008-0303-1.CrossRefPubMedPubMedCentral
38.
Laumen H, Saningong AD, Heid IM, Hess J, Herder C, Claussnitzer M, Baumert J, Lamina C, Rathmann W, Sedlmeier EM, Klopp N, Thorand B, Wichmann HE, Illig T, Hauner H: Functional characterization of promoter variants of the adiponectin gene complemented by epidemiological data. Diabetes. 2009, 58: 984-991. 10.2337/db07-1646.CrossRefPubMed
39.
Xu Y, He B, Pan Y, Gu L, Nie Z, Chen L, Li R, Gao T, Wang S: The roles of ADIPOQ genetic variations in cancer risk: evidence from published studies. Mol Biol Rep. 2013, 40: 1135-1144. 10.1007/s11033-012-2154-2.CrossRefPubMed
Metadata
Title
Associations between variants on ADIPOQ and ADIPOR1 with colorectal cancer risk: a chinese case-control study and updated meta-analysis
Authors
Yiyi Ou
Peizhan Chen
Ziyuan Zhou
Chenglin Li
Jinyi Liu
Kazuo Tajima
Junsheng Guo
Jia Cao
Hui Wang
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Medical Genetics / Issue 1/2014
Electronic ISSN: 1471-2350
DOI
https://doi.org/10.1186/s12881-014-0137-y

Other articles of this Issue 1/2014

BMC Medical Genetics 1/2014 Go to the issue

Research article

Autism-epilepsy phenotype with macrocephaly suggests PTEN, but not GLIALCAM, genetic screening

Case report

A coalescence of two syndromes in a girl with terminal deletion and inverted duplication of chromosome 5

Study protocol

A recall-by-genotype study of CHRNA5-A3-B4genotype, cotinine and smoking topography: study protocol

Research article

No evidence for copy number and methylation variation in H19 and KCNQ10T1 imprinting control regions in children born small for gestational age

Research article

Identification of CDH23 mutations in Korean families with hearing loss by whole-exome sequencing

Research article

Clinical and GAA gene mutation analysis in mainland Chinese patients with late-onset Pompe disease: identifying c.2238G > C as the most common mutation