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Cancer Causes & Control
Published in: Cancer Causes & Control 9/2009

01-11-2009 | Original paper

Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer

Authors: Konstantinos K. Tsilidis, Kathy J. Helzlsouer, Michael W. Smith, Victoriya Grinberg, Judith Hoffman-Bolton, Sandra L. Clipp, Kala Visvanathan, Elizabeth A. Platz

Published in: Cancer Causes & Control | Issue 9/2009

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Abstract

Objective and methods

The association of 17 candidate single nucleotide polymorphisms (SNPs) in IL10 and other immune response genes (CRP, TLR4, IL6, IL1B, IL8, TNF, RNASEL) and genes related to obesity (PPARG, TCF7L2, ADIPOQ, LEP) with colorectal cancer was investigated. Haplotype tagging SNPs were chosen for IL10, CRP, and TLR4. Incident colorectal cancer cases (n = 208) and matched controls (n = 381) were identified between baseline in 1989 and 2003 among participants in the CLUE II cohort. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using conditional logistic regression.

Results

Compared with the AA genotype at the candidate IL10-1082 locus (rs1800896), carrying one (OR, 0.79; 95% CI, 0.53–1.18) or two (OR, 0.58; 95% CI, 0.35–0.95) G alleles, a known higher producer of the anti-inflammatory cytokine IL-10, was associated with lower risk of colorectal cancer (p trend = 0.03). Statistically significant associations with colorectal cancer were observed for three tagSNPs in IL10 (rs1800890, rs3024496, rs3024498) and one common haplotype, but these associations were due to high linkage disequilibrium with IL10-1082. Two CRP haplotypes (global p = 0.04) and TLR4 tagSNPs (rs7873784, rs11536891), but not TLR4 haplotypes, were associated with colorectal cancer.

Conclusions

Our study suggests that polymorphisms in IL10, and also possibly in CRP and other genes related to immune response or obesity may be associated with colorectal cancer.
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Metadata
Title
Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer
Authors
Konstantinos K. Tsilidis
Kathy J. Helzlsouer
Michael W. Smith
Victoriya Grinberg
Judith Hoffman-Bolton
Sandra L. Clipp
Kala Visvanathan
Elizabeth A. Platz
Publication date
01-11-2009
Publisher
Springer Netherlands
Published in
Cancer Causes & Control / Issue 9/2009
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-009-9427-7

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