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Neuroscience Bulletin
Published in: Neuroscience Bulletin 1/2016

01-02-2016 | Original Article

Association of Optic Radiation Integrity with Cortical Thickness in Children with Anisometropic Amblyopia

Authors: Shun Qi, Yun-Feng Mu, Long-Biao Cui, Rong Li, Mei Shi, Ying Liu, Jun-Qing Xu, Jian Zhang, Jian Yang, Hong Yin

Published in: Neuroscience Bulletin | Issue 1/2016

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Abstract

Previous studies have indicated regional abnormalities of both gray and white matter in amblyopia. However, alterations of cortical thickness associated with changes in white matter integrity have rarely been reported. In this study, structural magnetic resonance imaging and diffusion tensor imaging (DTI) data were obtained from 15 children with anisometropic amblyopia and 15 age- and gender-matched children with normal sight. Combining DTI and surface-based morphometry, we examined a potential linkage between disrupted white matter integrity and altered cortical thickness. The fractional anisotropy (FA) values in the optic radiations (ORs) of children with anisometropic amblyopia were lower than in controls (P < 0.05). The cortical thickness in amblyopic children was lower than controls in the following subregions: lingual cortex, lateral occipitotemporal gyrus, cuneus, occipital lobe, inferior parietal lobe, and temporal lobe (P < 0.05, corrected), but was higher in the calcarine gyrus (P < 0.05, corrected). Node-by-node correlation analysis of changes in cortical thickness revealed a significant association between a lower FA value in the OR and diminished cortical thickness in the following subregions: medial lingual cortex, lateral occipitotemporal gyrus, lateral, superior, and medial occipital cortex, and lunate cortex. We also found a relationship between changes of cortical thickness and white matter OR integrity in amblyopia. These findings indicate that developmental changes occur simultaneously in the OR and visual cortex in amblyopia, and provide key information on complex damage of brain networks in anisometropic amblyopia. Our results also support the hypothesis that the pathogenesis of anisometropic amblyopia is neurodevelopmental.
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Metadata
Title
Association of Optic Radiation Integrity with Cortical Thickness in Children with Anisometropic Amblyopia
Authors
Shun Qi
Yun-Feng Mu
Long-Biao Cui
Rong Li
Mei Shi
Ying Liu
Jun-Qing Xu
Jian Zhang
Jian Yang
Hong Yin
Publication date
01-02-2016
Publisher
Springer Singapore
Published in
Neuroscience Bulletin / Issue 1/2016
Print ISSN: 1673-7067
Electronic ISSN: 1995-8218
DOI
https://doi.org/10.1007/s12264-015-0005-6

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