Published in:
01-06-2012 | Research Letter
Association of genetic variations of PRDM16 with metabolic syndrome in a general Xinjiang Uygur population
Authors:
Ju Hong Zhang, Nan Fang Li, Zhi Tao Yan, De Lian Zhang, Hong Mei Wang, Yan Ying Guo, Zhou Ling
Published in:
Endocrine
|
Issue 3/2012
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Excerpt
The function of brown fat in metabolic syndrome (MetS) has been followed with great interest in recent years. Positive regulatory domain containing 16 (PRDM16) has been shown to control a bidirectional cell fate switch between skeletal myoblasts and brown adipocytes [
1]. We hypothesized that genetic variants within the
PRDM16 gene may be associated with MetS. At present, only one study so far has reported a genetic association between
PPRDM16 and MetS [
2]. So, the aim of this study was to search for common and novel sequence variations in
PRDM16 and to determine whether variants in this gene influence susceptibility to MetS. …
