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European Radiology

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01-02-2016 | Magnetic Resonance

Assessment of renal allograft function early after transplantation with isotropic resolution diffusion tensor imaging

Authors: Wen-jun Fan, Tao Ren, Qiong Li, Pan-li Zuo, Miao-miao Long, Chun-bai Mo, Li-hua Chen, Li-xiang Huang, Wen Shen

Published in: European Radiology | Issue 2/2016

Abstract

Objectives

To investigate the value of diffusion tensor imaging (DTI) and tractography in renal allografts at the early stage after kidney transplantation.

Methods

This study was approved by the institutional ethical review committee, and written informed consent was obtained. A total of 54 renal allograft recipients 2–3 weeks after transplantation and 26 age-matched healthy volunteers underwent renal DTI with a 3.0-T magnetic resonance imaging (MRI) system. Recipients were divided into three groups according to the estimated glomerular filtration rate (eGFR). Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) of the cortex and medulla were measured and compared among the groups. Whole-kidney tractography was performed. Correlation of eGFR with diffusion parameters was evaluated.

Results

In allografts with stable function, the medullary ADC was higher and the cortical FA was lower (p < 0.001) than in healthy kidneys. The cortical ADC, medullary ADC and FA decreased as the allograft function declined, and with a positive correlation with eGFR (p < 0.001); cortical FA did not. Tractography demonstrated a decrease of tract density in impaired functional allografts.

Conclusions

Renal DTI produces reliable results to assess renal allograft function at the early stage after transplantation.

Key Points

• DTI and tractography can evaluate renal allograft function at an early stage

• Medullary FA, cortical and medullary ADC can effectively evaluate allograft function

• Medullary FA, cortical and medullary ADC are correlated with eGFR in renal allografts

• Medullary ADC increased and cortical FA decreased in stable allografts compared to control subjects

• Medullary FA, cortical and medullary ADC decreased and allograft function declined

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Title: Assessment of renal allograft function early after transplantation with isotropic resolution diffusion tensor imaging
Authors: Wen-jun Fan
Tao Ren
Qiong Li
Pan-li Zuo
Miao-miao Long
Chun-bai Mo
Li-hua Chen
Li-xiang Huang
Wen Shen
Publication date: 01-02-2016
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 2/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-015-3841-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Assessment of renal allograft function early after transplantation with isotropic resolution diffusion tensor imaging

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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