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European Radiology
Published in: European Radiology 3/2015

01-03-2015 | Magnetic Resonance

Chronic kidney disease: pathological and functional assessment with diffusion tensor imaging at 3T MR

Authors: Zhiling Liu, Ying Xu, Jie Zhang, Junhui Zhen, Rong Wang, Shifeng Cai, Xianshun Yuan, Qingwei Liu

Published in: European Radiology | Issue 3/2015

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Abstract

Objective

Our objective was to evaluate pathological and functional changes in chronic kidney disease (CKD) using diffusion tensor imaging (DTI) at 3 T.

Methods

There were fifty-one patients with CKD who required biopsy and 19 healthy volunteers who were examined using DTI at 3 T. The mean values of fractional anisotropy (FA) and the apparent diffusion coefficient (ADC) were obtained from the renal parenchyma (cortex and medulla). Correlations between imaging results and the estimated glomerular filtration rate (eGFR), as well as pathological damage (glomerular lesion and tubulointerstitial injury), were evaluated.

Results

The renal cortical FA was significantly lower than the medullary in both normal and affected kidneys (p < 0.001). The parenchymal FA was significantly lower in patients than healthy controls, regardless of whether eGFR was reduced. There were positive correlations between eGFR and FA (cortex, r = 0.689, p = 0.000; and medulla, r = 0.696, p = 0.000), and between eGFR and ADC (cortex, r = 0.310, p = 0.017; and medulla, r = 0.356, p = 0.010). Negative correlations were found between FA and the glomerular lesion (cortex, r = -0.499, p = 0.000; and medulla, r = -0.530, p = 0.000), and between FA and tubulointerstitial injury (cortex, r = -0.631, p = 0.000; and medulla, r = -0.724, p = 0.000).

Conclusion

DTI is valuable for noninvasive assessment of renal function and pathology in patients with CKD. A decrease in FA could identify the glomerular lesions, tubulointerstitial injuries, and eGFR.

Key Points

• DTI can evaluate CKD regardless of whether the eGFR is reduced.
• DTI allows the assessment of renal pathology changes.
• FA appears sensitive and stable in detecting renal pathology and function.
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Metadata
Title
Chronic kidney disease: pathological and functional assessment with diffusion tensor imaging at 3T MR
Authors
Zhiling Liu
Ying Xu
Jie Zhang
Junhui Zhen
Rong Wang
Shifeng Cai
Xianshun Yuan
Qingwei Liu
Publication date
01-03-2015
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 3/2015
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-014-3461-x

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