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BMC Oral Health
Published in: BMC Oral Health 1/2023

Open Access 01-12-2023 | Arterial Occlusive Disease | Research

The effect of APN, hs-CRP and APN/hs-CRP in periodontitis with DAA

Authors: Rui Cheng, Xiaojiang Xu, Shurong Yang, Zhongqian mi, Yong Zhao, Chong Wang, Xuexue Shi, Jinhua Gao, Feiyan Yu, Xiuyun Ren

Published in: BMC Oral Health | Issue 1/2023

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Abstract

Background

Common chronic infections induced low-grade inflammation has been correlated with atherosclerosis as supported by strong evidence. The balance between pro-and anti-inflammatory factors was exploited to elucidate the effects of chronic periodontitis on diabetes-associated atherosclerosis.

Methods

Study subjects encompassed 30 SPF male rats randomly divided into four groups: A group (NC), B group (T2DM), C group (CP), D group (DM + CP). After developing the model, blood samples were collected from the angular vein analyze serum APN, hs-CRP, and blood lipid. the carotid artery was isolated for HE staining.

Result

Compared with group A, the serum APN in group B, C and D decreased gradually with the progression of the disease. Serum hs-CRP in group B, C and D was significantly increased. At T3, T4 and T5 in group B, C and D, APN/hs-CRP significantly decreased. TC, LDL and TG significantly increased in group B, D; HDL significantly decreased in group C. Carotid artery HE staining showed: compared with group A, different degrees of endothelial defect, destruction of elastic fibers in the middle membrane, disorder of smooth muscle arrangement, and partial dissolution 、 fragmentation and Calcium salt deposition necrosis occurred in group B, C and D.

Conclusion

Enhanced systemic inflammation, decreased adiponectin level, and disorganized lipid metabolism with or without type 2 diabetes attributed to local inflammation of periodontitis can result in an imbalance of pro-inflammatory and anti-inflammatory effects. Therefore, it’s more meaningful to predict the progression of DAA with anti-inflammatory/pro-inflammatory variation.
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Metadata
Title
The effect of APN, hs-CRP and APN/hs-CRP in periodontitis with DAA
Authors
Rui Cheng
Xiaojiang Xu
Shurong Yang
Zhongqian mi
Yong Zhao
Chong Wang
Xuexue Shi
Jinhua Gao
Feiyan Yu
Xiuyun Ren
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2023
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-023-02765-x

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