Abstract
The development of atherosclerotic lesions leading to myocardial infarction (MI) or stroke encompasses a cascade of cellular and molecular events that can well be characterized as a chronic immune-mediated inflammation occurring preferentially in the biologic surrounding of the so called metabolic syndrome. Adipokines, chemokines, cytokines, and their receptors are critically involved in the initiation and perpetuation of atherosclerosis, and they play important roles at all levels in the pathogenesis of this disease. Metabolic risk profiles associated with sedentary lifestyle, obesity, especially intra-abdominal fat accumulation, insulin resistance, and dyslipidemia pave the way for a chronic, immunemediated vascular inflammation around vascular lipid deposits. In the present article, the impact of adiponectin, monocyte and T-cell associated cytokines (with emphasis on Neopterin), individual adipose tissue - distribution, and pleiotropic drug effects on the individual course of atherosclerosis and associated cardiovascular disease are reviewed.
Keywords: Adiposity, immune-mediated inflammation, cardiovascular risk, atherosclerotic lesions, metabolic syndrome, adiponectin, monocyte, T-cell, cytokines, Neopterin, cardiovascular disease (CVD), systemic disease, T-lymphocytes, neopterin,obesity, myocardial infarction (MI), homocystein, lowdensity lipoproteins (LDL), atherogenesis, angiogenesis, high sensitive C-reactive protein (hsCRP), intima-media thickness, remodelling, cytokine, chemokine, metalloproteinase, dendritic, foam,osteoclast, nuclear factor, kappaB ligand, osteoprotegerin, T-helper lymphocytes of type 1 (Th-1), reactive oxygen species (ROS), macrophages, monocyte chemotactic protein (MCP), endocannabinoids, oxidation, anti-atherogenic role, sympathetic nervous system, Hypoxia, kappa-B, hypoadiponectinemia, nitric oxide (NO), endothelial NO synthase (eNOS), asymmetric dimethylarginine, bioavailibility, VSMCs, rheumatoid arthritis (RA), systemic lupus erythematodes
Current Medicinal Chemistry
Title: Inflammation, Adiponectin, Obesity and Cardiovascular Risk
Volume: 17 Issue: 36
Author(s): H. Mangge, G. Almer, M. Truschnig-Wilders, A. Schmidt, R. Gasser and D. Fuchs
Affiliation:
Keywords: Adiposity, immune-mediated inflammation, cardiovascular risk, atherosclerotic lesions, metabolic syndrome, adiponectin, monocyte, T-cell, cytokines, Neopterin, cardiovascular disease (CVD), systemic disease, T-lymphocytes, neopterin,obesity, myocardial infarction (MI), homocystein, lowdensity lipoproteins (LDL), atherogenesis, angiogenesis, high sensitive C-reactive protein (hsCRP), intima-media thickness, remodelling, cytokine, chemokine, metalloproteinase, dendritic, foam,osteoclast, nuclear factor, kappaB ligand, osteoprotegerin, T-helper lymphocytes of type 1 (Th-1), reactive oxygen species (ROS), macrophages, monocyte chemotactic protein (MCP), endocannabinoids, oxidation, anti-atherogenic role, sympathetic nervous system, Hypoxia, kappa-B, hypoadiponectinemia, nitric oxide (NO), endothelial NO synthase (eNOS), asymmetric dimethylarginine, bioavailibility, VSMCs, rheumatoid arthritis (RA), systemic lupus erythematodes
Abstract: The development of atherosclerotic lesions leading to myocardial infarction (MI) or stroke encompasses a cascade of cellular and molecular events that can well be characterized as a chronic immune-mediated inflammation occurring preferentially in the biologic surrounding of the so called metabolic syndrome. Adipokines, chemokines, cytokines, and their receptors are critically involved in the initiation and perpetuation of atherosclerosis, and they play important roles at all levels in the pathogenesis of this disease. Metabolic risk profiles associated with sedentary lifestyle, obesity, especially intra-abdominal fat accumulation, insulin resistance, and dyslipidemia pave the way for a chronic, immunemediated vascular inflammation around vascular lipid deposits. In the present article, the impact of adiponectin, monocyte and T-cell associated cytokines (with emphasis on Neopterin), individual adipose tissue - distribution, and pleiotropic drug effects on the individual course of atherosclerosis and associated cardiovascular disease are reviewed.
Export Options
About this article
Cite this article as:
Mangge H., Almer G., Truschnig-Wilders M., Schmidt A., Gasser R. and Fuchs D., Inflammation, Adiponectin, Obesity and Cardiovascular Risk, Current Medicinal Chemistry 2010; 17 (36) . https://dx.doi.org/10.2174/092986710794183006
DOI https://dx.doi.org/10.2174/092986710794183006 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Periodontal Disease and Potential Association with Systemic Diseases and Conditions (Mini-review)
Applied Clinical Research, Clinical Trials and Regulatory Affairs The Role of Fibrate Treatment in Dyslipidemia: An Overview
Current Pharmaceutical Design Nebivolol: More Than a Highly Selective Beta Blocker
Recent Patents on Cardiovascular Drug Discovery Congenital Parenchymal Lesions of the Lung
Current Respiratory Medicine Reviews Impact of Diabetes on Cardiac and Vascular Disease: Role of Calcium Signaling
Current Medicinal Chemistry Polyphenols: A Potential New Strategy for the Prevention and Treatment of Anxiety and Depression
Current Nutrition & Food Science Beta Blocker Use After Acute Myocardial Infarction in the Patient with Normal Systolic Function: When is it “Ok” to Discontinue?
Current Cardiology Reviews Preconditioning with Chronic Cerebral Hypoperfusion Reduces a Focal Cerebral Ischemic Injury and Increases Apurinic/Apyrimidinic Endonuclease/Redox Factor-1 and Matrix Metalloproteinase-2 Expression
Current Neurovascular Research Angiotensin II and Abdominal Aortic Aneurysms: An update
Current Pharmaceutical Design The Developing Role of Neuregulin1 In Cardiac Regenerative Stem Cell Therapy
Current Pharmaceutical Design A Review of Natural and Synthetic Antioxidants Important for Health and Longevity
Current Medicinal Chemistry Peroxisome Proliferator-Activated Receptor (PPAR) in Metabolic Syndrome and Type 2 Diabetes Mellitus
Current Diabetes Reviews Resveratrol and Its Analogues: Promising Antitumor Agents
Anti-Cancer Agents in Medicinal Chemistry Fragmented ECG as a Risk Marker in Cardiovascular Diseases
Current Cardiology Reviews Inflammation and Chronic Heart Failure: From Biomarkers to Novel Anti-inflammatory Therapeutic Strategies
Medicinal Chemistry Stabilization of Neutral NH2-R-COOH Form of the Antihypertensive Peptides L-Valyl-L-Prolyl-L-Proline and L-Isoleucyl-L-Prolyl-L-Proline
Protein & Peptide Letters Energy Balance and Carcinogenesis: Underlying Pathways and Targets for Intervention
Current Cancer Drug Targets Inflamm-Aging, Cytokines and Aging: State of the Art, New Hypotheses on the Role of Mitochondria and New Perspectives from Systems Biology
Current Pharmaceutical Design Complications of the Chest Wall and the Respiratory System After Surgery and Functional Performance
Current Respiratory Medicine Reviews Susceptibility of Periodontopathogenic and Cariogenic Bacteria to Defensins and Potential Therapeutic Use of Defensins in Oral Diseases
Current Pharmaceutical Design