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BMC Oral Health
Published in: BMC Oral Health 1/2023

Open Access 01-12-2023 | Research

Clinical relevance of serum lipids in the carcinogenesis of oral squamous cell carcinoma

Authors: Ling Qian, Bo Qian, Juanyong Xu, Jingjing Yang, Guoying Wu, Yuping Zhao, Qinglan Liu, Zhiran Yuan, Yuan Fan, Huaiqi Li

Published in: BMC Oral Health | Issue 1/2023

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Abstract

Background

Dyslipidaemia is associated with cancers. However, the specific expression of serum lipids in oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC) remains unclear, and it remains unknown whether serum lipids are associated with the development of OPMD and OSCC. This study investigated the serum lipid profiles of OPMD and OSCC patients, and the association of serum lipids with the occurrence of OPMD and OSCC.

Methods

A total of 532 patients were recruited from the Affiliated Hospital of Stomatology, Nanjing Medical University. Serum lipid parameters including total cholesterol (TC), triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A (Apo-A), apolipoprotein B (Apo-B), and lipoprotein (a) (Lpa) were analysed, and clinicopathological data were collected for further analysis. Furthermore, a regression model was used to evaluate the relationship between serum lipids and the occurrence of OSCC and OPMD.

Results

After adjusting for age and sex, no significant differences were observed in serum lipid or body mass index (BMI) between OSCC patients and controls (P > 0.05). HDL-C, Apo-A, and Apo-B levels were lower in OSCC patients than in OPMD patients (P < 0.05); HDL-C and Apo-A levels were higher in OPMD patients than in controls (P < 0.05). Furthermore, female OSCC patients had higher Apo-A and BMI values than males. The HDL-C level was lower in patients under 60 years of age than in elders (P < 0.05); and age was related to a higher risk of developing OSCC. Female patients with OPMD had higher TC, HDL-C, and Apo-A levels than males (P < 0.05); OPMD patients over 60 years of age had higher HDL-C than youngers (P < 0.05), whereas the LDL-C level was lower in elders (P < 0.05). The HDL-C and BMI values of the patients with oral leukoplakia (OLK) with dysplasia were more elevated than those of the oral lichen planus group, and the LDL-C, and Apo-A levels in patients with OLK with dysplasia were decreased (P < 0.05). Sex, high HDL-C and Apo-A values were associated with the development of OPMD.

Conclusion

Serum lipids exhibited certain differences according to the occurrence and development of OSCC; high levels of HDL-C and Apo-A might be markers for predicting OPMD.
Literature
1.
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49.CrossRefPubMed
2.
Bonner JA, Harari PM, Giralt J, Cohen RB, Jones CU, Sur RK, Raben D, Baselga J, Spencer SA, Zhu J, Youssoufian H, Rowinsky EK, Ang KK. Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol. 2010;11(1):21–8.CrossRefPubMed
3.
Ferris RL, Blumenschein G Jr, Fayette J, Guigay J, Colevas AD, Licitra L, Harrington K, Kasper S, Vokes EE, Even C, Worden F, Saba NF, Iglesias Docampo LC, Haddad R, Rordorf T, Kiyota N, Tahara M, Monga M, Lynch M, Geese WJ, Kopit J, Shaw JW, Gillison ML. Nivolumab for recurrent squamous-cell carcinoma of the Head and Neck. N Engl J Med. 2016;375(19):1856–67.CrossRefPubMedPubMedCentral
4.
James A, Bonner PMH, Giralt J, Azarnia N, Shin DM, Cohen RB, Jones CU, Sur R, Raben D, Jassem J, Ove R, Kies MS. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 2006;354(6):567–78. Jose Baselga, Hagop Youssoufian, Nadia Amellal, Eric K. Rowinsky, K. Kian Ang.CrossRef
5.
Warnakulasuriya S. Oral potentially malignant disorders: a comprehensive review on clinical aspects and management. Oral Oncol. 2020;102:104550.CrossRefPubMed
6.
Warnakulasuriya S, Kujan O, Aguirre-Urizar JM, Bagan JV, Gonzalez-Moles MA, Kerr AR, Lodi G, Mello FW, Monteiro L, Ogden GR, Sloan P, Johnson NW. Oral potentially malignant disorders: a consensus report from an international seminar on nomenclature and classification, convened by the WHO collaborating centre for oral Cancer. Oral Dis. 2021;27(8):1862–80.CrossRefPubMed
7.
Kerr AR, Lodi G. Management of oral potentially malignant disorders. Oral Dis. 2021;27(8):2008–25.CrossRefPubMed
8.
Iocca O, Sollecito TP, Alawi F, Weinstein GS, Newman JG, De Virgilio A, Di Maio P, Spriano G, Pardinas Lopez S, Shanti RM. Potentially malignant disorders of the oral cavity and oral dysplasia: a systematic review and meta-analysis of malignant transformation rate by subtype. Head Neck. 2020;42(3):539–55.CrossRefPubMed
9.
10.
Cotte AK, Aires V, Fredon M, Limagne E, Derangere V, Thibaudin M, Humblin E, Scagliarini A, de Barros JP, Hillon P, Ghiringhelli F, Delmas D. Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance. Nat Commun. 2018;9(1):322.CrossRefPubMedPubMedCentral
11.
Koundouros N, Poulogiannis G. Reprogramming of fatty acid metabolism in cancer. Br J Cancer. 2020;122(1):4–22.CrossRefPubMed
12.
13.
Schiliro C, Firestein BL. Mechanisms of Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation.Cells. 2021;10(5).
14.
Qin WH, Yang ZS, Li M, Chen Y, Zhao XF, Qin YY, Song JQ, Wang BB, Yuan B, Cui XL, Shen F, He J, Bi YF, Ning G, Fu J, Wang HY. High serum levels of cholesterol increase Antitumor Functions of Nature Killer cells and reduce growth of liver tumors in mice. Gastroenterology. 2020;158(6):1713–27.CrossRefPubMed
15.
Hao B, Yu M, Sang C, Bi B, Chen J. Dyslipidemia and non-small cell lung cancer risk in chinese population: a case-control study. Lipids Health Dis. 2018;17(1):278.CrossRefPubMedPubMedCentral
16.
Tang M, Song C, Zhang Y, Xu X, Wang C, Zhang Z, Chen T. Levels of pretreatment blood lipids are prognostic factors in advanced NSCLC patients treated with anlotinib. Lipids Health Dis. 2021;20(1):165.CrossRefPubMedPubMedCentral
17.
Lin F, Zheng R, Yu C, Su Y, Yan X, Qu F. Predictive role of serum cholesterol and triglycerides in cervical cancer survival. Int J Gynecol Cancer. 2021;31(2):171–6.CrossRefPubMed
18.
Patel KK, Kashfi K. Lipoproteins and cancer: the role of HDL-C, LDL-C, and cholesterol-lowering drugs. Biochem Pharmacol. 2022;196:114654.CrossRefPubMed
19.
Fang Z, He M, Song M. Serum lipid profiles and risk of colorectal cancer: a prospective cohort study in the UK Biobank. Br J Cancer. 2021;124(3):663–70.CrossRefPubMed
20.
Harborg S, Ahern TP, Feldt M, Rosendahl AH, Cronin-Fenton D, Melander O, Borgquist S. Circulating lipids and breast cancer prognosis in the Malmo diet and cancer study. Breast Cancer Res Treat. 2022;191(3):611–21.CrossRefPubMed
21.
Li G, Da M, Zhang W, Wu H, Ye J, Chen J, Ma L, Gu N, Wu Y, Song X. Alteration of serum lipid profile and its prognostic value in head and neck squamous cell carcinoma. J Oral Pathol Med. 2016;45(3):167–72.CrossRefPubMed
22.
Wilms T, Boldrup L, Gu X, Coates PJ, Sgaramella N, Nylander K. High Levels of Low-Density Lipoproteins Correlate with Improved Survival in Patients with Squamous Cell Carcinoma of the Head and Neck.Biomedicines. 2021;9(5).
23.
Gupta S, Gupta S. Alterations in serum lipid profile patterns in oral cancer and oral precancerous lesions and conditions—a clinical study. Indian J Dentistry. 2011;2(2):1–7.CrossRef
24.
Subbulakshmi AC, Mohan N, Thiruneervannan R, Naveen S. Comparative evaluation of serum lipid Profile in patients with oral Submucous fibrosis and oral squamous cell carcinoma with that of control subjects: a Case Control Study. J Pharm Bioallied Sci. 2017;9(Suppl 1):191–S6.CrossRef
25.
Wang X, Wang Y, Wang M, Chen X, Cui W, Chen X. The association between serum lipid levels and histological type of breast cancer. Eur J Med Res. 2022;27(1):154.CrossRefPubMedPubMedCentral
26.
Goto W, Kashiwagi S, Kamei Y, Watanabe C, Aomatsu N, Ikeda K, Ogawa Y, Hirakawa K, Ohira M. Relationship between serum lipid levels and the immune microenvironment in breast cancer patients: a retrospective study. BMC Cancer. 2022;22(1):167.CrossRefPubMedPubMedCentral
27.
Yang Z, Tang H, Lu S, Sun X, Rao B. Relationship between serum lipid level and colorectal cancer: a systemic review and meta-analysis. BMJ Open. 2022;12(6):e052373.CrossRefPubMedPubMedCentral
28.
Mitchell JM, Flight RM, Moseley HNB. Untargeted Lipidomics of Non-Small Cell Lung Carcinoma Demonstrates Differentially Abundant Lipid Classes in Cancer vs.Non-Cancer Tissue. Metabolites. 2021;11(11).
29.
Buechler C, Aslanidis C. Role of lipids in pathophysiology, diagnosis and therapy of hepatocellular carcinoma. Biochim Biophys Acta Mol Cell Biol Lipids. 2020;1865(5):158658.CrossRefPubMed
30.
31.
Filali-Mouncef Y, Hunter C, Roccio F, Zagkou S, Dupont N, Primard C, Proikas-Cezanne T, Reggiori F. The menage a trois of autophagy, lipid droplets and liver disease. Autophagy. 2022;18(1):50–72.CrossRefPubMed
32.
Paoli A, Mancin L, Giacona MC, Bianco A, Caprio M. Effects of a ketogenic diet in overweight women with polycystic ovary syndrome. J Transl Med. 2020;18(1):104.CrossRefPubMedPubMedCentral
33.
Xuan Q, Hu C, Zhang Y, Wang Q, Zhao X, Liu X, Wang C, Jia W, Xu G. Serum lipidomics profiles reveal potential lipid markers for prediabetes and type 2 diabetes in patients from multiple communities. Front Endocrinol (Lausanne). 2022;13:966823.CrossRefPubMed
34.
Choi RH, Tatum SM, Symons JD, Summers SA, Holland WL. Ceramides and other sphingolipids as drivers of cardiovascular disease. Nat Rev Cardiol. 2021;18(10):701–11.CrossRefPubMedPubMedCentral
35.
Lohe VK, Degwekar SS, Bhowate RR, Kadu RP, Dangore SB. Evaluation of correlation of serum lipid profile in patients with oral cancer and precancer and its association with tobacco abuse. J Oral Pathol Med. 2010;39(2):141–8.CrossRefPubMed
36.
Arnold M, Ferlay J, van Berge Henegouwen MI, Soerjomataram I. Global burden of oesophageal and gastric cancer by histology and subsite in 2018. Gut. 2020;69(9):1564–71.CrossRefPubMed
37.
Oh LJ, Asher R, Veness M, Smee R, Goldstein D, Gopalakrishna Iyer N, Balasubramanian D, Low TH, Palme CE, Gupta R, Clark J. Effect of age and gender in non-smokers with oral squamous cell carcinoma: multi-institutional study. Oral Oncol. 2021;116:105210.CrossRefPubMed
38.
Luo J, Yang H, Song BL. Mechanisms and regulation of cholesterol homeostasis. Nat Rev Mol Cell Biol. 2020;21(4):225–45.CrossRefPubMed
39.
Garcia-Ruiz C, de la Conde L, Ribas V, Fernandez-Checa JC. Mitochondrial cholesterol and Cancer. Semin Cancer Biol. 2021;73:76–85.CrossRefPubMed
40.
41.
Georgila K, Vyrla D, Drakos E. Apolipoprotein A-I (ApoA-I), Immunity, Inflammation and Cancer.Cancers (Basel). 2019;11(8).
42.
Wang C, Lin T, Wang X, Yu Z, Zhuge X, Cui W, Wang M, Wang Z, Guo C, Chen X. Low high-density lipoprotein cholesterol levels are associated with malignant intraductal papillary mucinous neoplasms: a multicenter study. Lipids Health Dis. 2021;20(1):94.CrossRefPubMedPubMedCentral
Metadata
Title
Clinical relevance of serum lipids in the carcinogenesis of oral squamous cell carcinoma
Authors
Ling Qian
Bo Qian
Juanyong Xu
Jingjing Yang
Guoying Wu
Yuping Zhao
Qinglan Liu
Zhiran Yuan
Yuan Fan
Huaiqi Li
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2023
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-023-02859-6

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