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Environmental Health and Preventive Medicine
Published in: Environmental Health and Preventive Medicine 1/2019

Open Access 01-12-2019 | Arterial Occlusive Disease | Research article

Short stature-related single-nucleotide polymorphism (SNP) activates endothelial repair activity in elderly Japanese

Authors: Yuji Shimizu, Hirotomo Yamanashi, Yuko Noguchi, Jun Koyamatsu, Mako Nagayoshi, Kairi Kiyoura, Shoichi Fukui, Mami Tamai, Shin-Ya Kawashiri, Kazuhiko Arima, Takahiro Maeda

Published in: Environmental Health and Preventive Medicine | Issue 1/2019

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Abstract

Background

Hypertension and atherosclerosis are bidirectionally related, while platelet count could serve as an indicator of endothelial repair. Therefore, high platelet counts could be associated with hypertension by indicating more intense endothelial repair activity. Furthermore, short stature has been shown to constitute a risk of atherosclerosis. Since inflammation-related single-nucleotide polymorphism (SNP (rs3782886)) is reportedly associated with myocardial infarction and short stature, rs3782886 could be associated with a high platelet count and thus more intense endothelial repair activity.

Methods

We conducted a cross-sectional study of 988 elderly Japanese who participated in a general health check-up. Short stature was defined as a height of at or under the 25th percentile of the study population, and high platelet count as the highest tertiles of the platelet levels.

Results

High platelet counts were found to be independently and positively associated with hypertension while rs3782886 was independently associated with high platelet levels and short stature. The classical cardiovascular risk factor-adjusted odds ratio (OR) and 95% confidence interval (CI) of high platelet count for hypertension was 1.34 (1.02, 1.77). With non-minor homo of the rs3782886 as the reference group, the adjusted OR and 95% CI for high platelet count and short stature of minor home were 2.40 (1.30, 4.42) and 2.21 (1.16, 4.21), respectively.

Conclusion

SNP (rs3782886) was shown to be associated with high platelet count and short stature. This result partly explains how a genetic factor can influence the impact of height on endothelial repair.
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Metadata
Title
Short stature-related single-nucleotide polymorphism (SNP) activates endothelial repair activity in elderly Japanese
Authors
Yuji Shimizu
Hirotomo Yamanashi
Yuko Noguchi
Jun Koyamatsu
Mako Nagayoshi
Kairi Kiyoura
Shoichi Fukui
Mami Tamai
Shin-Ya Kawashiri
Kazuhiko Arima
Takahiro Maeda
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Environmental Health and Preventive Medicine / Issue 1/2019
Print ISSN: 1342-078X
Electronic ISSN: 1347-4715
DOI
https://doi.org/10.1186/s12199-019-0780-1

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