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Environmental Health and Preventive Medicine

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Open Access 01-12-2018 | Research article

Hepatocyte growth factor and carotid intima-media thickness in relation to circulating CD34-positive cell levels

Authors: Yuji Shimizu, Shimpei Sato, Jun Koyamatsu, Hirotomo Yamanashi, Mako Nagayoshi, Shin-Ya Kawashiri, Keita Inoue, Shoichi Fukui, Hideaki Kondo, Seiko Nakamichi, Yasuhiro Nagata, Takahiro Maeda

Published in: Environmental Health and Preventive Medicine | Issue 1/2018

Abstract

Background

Hepatocyte growth factor (HGF) may act as a possible biochemical index for vascular damage, although evidence for the association between HGF and carotid intima-media thickness (CIMT) is limited. Since both HGF and circulating CD34-positive cells play an important role in endothelial repair, circulating CD34-positive cell levels may influence the association between HGF and CIMT.

Methods

We conducted a cross-sectional study of 269 elderly Japanese men aged 60–69 years who had undertaken an annual medical checkup from 2014 to 2015.

Results

The median value for circulating CD34-positive cells was 0.93 cells/μL. Among the study population, 135 men showed low circulating CD34-positive cell levels (≤ 0.93 cells/μL). By multivariable linear regression analysis, HGF was found to be significantly positively associated with CIMT only to participants with low circulating CD34-positive cell levels, with a multi-adjusted β of 0.26 (p = 0.005) and 0.002 (0.986) for low and high circulating CD34-positive cell levels, respectively. In addition, a significant interaction was observed between HGF and circulating CD34-positive cell levels (low and high) on CIMT (multivariable p value of 0.049). A positive association exists between HGF and CIMT in elderly Japanese men, limited to participants with low circulating CD34-positive cell levels.

Conclusion

A positive association exists between HGF and CIMT in community-dwelling elderly Japanese men, which is limited to participants with low numbers of circulating CD34-positive cells. Our findings indicate that circulating CD34-positive cell levels could determine the influence of HGF on CIMT in elderly Japanese men.

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Title: Hepatocyte growth factor and carotid intima-media thickness in relation to circulating CD34-positive cell levels
Authors: Yuji Shimizu
Shimpei Sato
Jun Koyamatsu
Hirotomo Yamanashi
Mako Nagayoshi
Shin-Ya Kawashiri
Keita Inoue
Shoichi Fukui
Hideaki Kondo
Seiko Nakamichi
Yasuhiro Nagata
Takahiro Maeda
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: Environmental Health and Preventive Medicine / Issue 1/2018
Print ISSN: 1342-078X
Electronic ISSN: 1347-4715
DOI: https://doi.org/10.1186/s12199-018-0705-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Hepatocyte growth factor and carotid intima-media thickness in relation to circulating CD34-positive cell levels

Abstract

Background

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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