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Published in: Current Cardiology Reports 10/2023

07-09-2023 | Arterial Diseases | Global Cardiovascular Health (L Sperling and D Gaita, Section Editors)

Arterial Stiffness and its Impact on Cardiovascular Health

Authors: Rachel Anne Xuereb, Caroline J. Magri, Robert G. Xuereb

Published in: Current Cardiology Reports | Issue 10/2023

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Abstract

Purpose of Review

Cardiovascular diseases are the leading cause of mortality globally. Identifying patients at risk is important to initiate preventive strategies. Over the last few decades, the role of the endothelium and its impact on arterial stiffness have been recognised as playing a pivotal role in cardiovascular disease. This review will focus on the effect of arterial stiffness in different patient cohorts with regard to cardiovascular morbidity and mortality, as well as its use in clinical practice.

Recent Findings

Arterial stiffness is associated with a range of cardiovascular risk factors and is an independent predictor of cardiovascular mortality. The gold standard for evaluating arterial stiffness is pulse wave velocity. Recently, cardio-ankle vascular index has been implemented as an easy and highly reproducible measure of arterial stiffness. Moreover, certain pharmacologic agents may modify arterial stiffness and alter progression of cardiovascular disease.

Summary

The endothelium plays an important role in cardiovascular disease. Implementing assessment of arterial stiffness in clinical practice will improve stratification of patients at risk of cardiovascular disease and help modify disease progression.
Literature
9.
go back to reference •• Fantin F, Giani A, Trentin M, Rossi AP, Zoico E, Mazzali G, et al. The correlation of arterial stiffness parameters with aging and comorbidity burden. J Clin Med. 2022;11(19):5761. https://doi.org/10.3390/jcm11195761. Recent study suggesting that arterial stiffness parameters can complement the characterization of patients affected by a remarkable comorbidity burden. •• Fantin F, Giani A, Trentin M, Rossi AP, Zoico E, Mazzali G, et al. The correlation of arterial stiffness parameters with aging and comorbidity burden. J Clin Med. 2022;11(19):5761. https://​doi.​org/​10.​3390/​jcm11195761. Recent study suggesting that arterial stiffness parameters can complement the characterization of patients affected by a remarkable comorbidity burden.
14.
go back to reference Zeiher AM, Drexler H, Saurbier B, Just H. Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension. J Clin Invest. 1993;92(2):652–62. https://doi.org/10.1172/JCI116634. Zeiher AM, Drexler H, Saurbier B, Just H. Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension. J Clin Invest. 1993;92(2):652–62. https://​doi.​org/​10.​1172/​JCI116634.
16.
go back to reference •• Hahad O, Arnold N, Prochaska JH, Panova-Noeva M, Schulz A, Lackner KJ, et al. Cigarette smoking is related to endothelial dysfunction of resistance, but not conduit arteries in the general population-results from the Gutenberg health study. Front Cardiovasc Med. 2021;8:674622. https://doi.org/10.3389/fcvm.2021.674622. Findings from this study suggest that cigarette smoking is associated with altered endothelial function of resistance. •• Hahad O, Arnold N, Prochaska JH, Panova-Noeva M, Schulz A, Lackner KJ, et al. Cigarette smoking is related to endothelial dysfunction of resistance, but not conduit arteries in the general population-results from the Gutenberg health study. Front Cardiovasc Med. 2021;8:674622. https://​doi.​org/​10.​3389/​fcvm.​2021.​674622. Findings from this study suggest that cigarette smoking is associated with altered endothelial function of resistance.
18.
go back to reference •• Yang Q, Wang P, Cai Y, Cui Y, Cui J, Du X, et al. Circulating microRNA-505 may serve as a prognostic biomarker for hypertension-associated endothelial dysfunction and inflammation. Front Cardiovasc Med. 2022;9:834121. https://doi.org/10.3389/fcvm.2022.834121. This study links for the first time miR-505 to endothelial dysfunction and inflammation under hypertensive conditions, supporting the translational value of miR-505 in prognosticating hypertension-associated endothelial impairment and inflammatory injuries in target organs such as the vessels and kidneys. •• Yang Q, Wang P, Cai Y, Cui Y, Cui J, Du X, et al. Circulating microRNA-505 may serve as a prognostic biomarker for hypertension-associated endothelial dysfunction and inflammation. Front Cardiovasc Med. 2022;9:834121. https://​doi.​org/​10.​3389/​fcvm.​2022.​834121. This study links for the first time miR-505 to endothelial dysfunction and inflammation under hypertensive conditions, supporting the translational value of miR-505 in prognosticating hypertension-associated endothelial impairment and inflammatory injuries in target organs such as the vessels and kidneys.
25.
go back to reference McVeigh GE, Allen PB, Morgan DR, Hanratty CG, Silke B. Nitric oxide modulation of blood vessel tone identified by arterial waveform analysis. Clin Sci (Lond). 2001;100(4):387–93 PMID: 11256976.CrossRefPubMed McVeigh GE, Allen PB, Morgan DR, Hanratty CG, Silke B. Nitric oxide modulation of blood vessel tone identified by arterial waveform analysis. Clin Sci (Lond). 2001;100(4):387–93 PMID: 11256976.CrossRefPubMed
27.
go back to reference Hadi HA, Carr CS, Al SJ. Endothelial dysfunction: cardiovascular risk factors, therapy, and outcome. Vasc Health Risk Manag. 2005;1(3):183–98 PMID: 17319104.PubMedPubMedCentral Hadi HA, Carr CS, Al SJ. Endothelial dysfunction: cardiovascular risk factors, therapy, and outcome. Vasc Health Risk Manag. 2005;1(3):183–98 PMID: 17319104.PubMedPubMedCentral
38.
go back to reference Franklin SS. Ageing and hypertension: the assessment of blood pressure indices in predicting coronary heart disease. J Hypertens Suppl. 1999;17(5):S29-36 PMID: 10706323.PubMed Franklin SS. Ageing and hypertension: the assessment of blood pressure indices in predicting coronary heart disease. J Hypertens Suppl. 1999;17(5):S29-36 PMID: 10706323.PubMed
47.
go back to reference Bramwell JC, Hill AV. The velocity of pulse wave in man. Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character. 1922;93(652):298–306. Bramwell JC, Hill AV. The velocity of pulse wave in man. Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character. 1922;93(652):298–306.
49.
go back to reference • Mitchell GF, Parise H, Benjamin EJ, Larson MG, Keyes MJ, Vita JA, et al. Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study. Hypertension. 2004;43(6):1239–45. https://doi.org/10.1161/01.HYP.0000128420.01881.aa. Findings from this study suggest that in a healthy cohort with a minimal burden of cardiovascular disease risk factors, an age-related increase in aortic stiffness, as compared with peripheral arterial stiffness, is associated with increasing forward wave amplitude and pulse pressure and reversal of the arterial stiffness gradient. • Mitchell GF, Parise H, Benjamin EJ, Larson MG, Keyes MJ, Vita JA, et al. Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study. Hypertension. 2004;43(6):1239–45. https://​doi.​org/​10.​1161/​01.​HYP.​0000128420.​01881.​aa. Findings from this study suggest that in a healthy cohort with a minimal burden of cardiovascular disease risk factors, an age-related increase in aortic stiffness, as compared with peripheral arterial stiffness, is associated with increasing forward wave amplitude and pulse pressure and reversal of the arterial stiffness gradient.
50.
go back to reference • Mendis S. The contribution of the Framingham Heart Study to the prevention of cardiovascular disease: a global perspective. Prog Cardiovasc Dis. 2010;53(1):10–4. https://doi.org/10.1016/j.pcad.2010.01.001. The Framingham Heart Study has also been in the forefront of the development of cardiovascular risk prediction equations for assessment of absolute risk. The Framingham Study provided insights into the prevalence, incidence, prognosis, predisposing factors and determinants of CVD. • Mendis S. The contribution of the Framingham Heart Study to the prevention of cardiovascular disease: a global perspective. Prog Cardiovasc Dis. 2010;53(1):10–4. https://​doi.​org/​10.​1016/​j.​pcad.​2010.​01.​001. The Framingham Heart Study has also been in the forefront of the development of cardiovascular risk prediction equations for assessment of absolute risk. The Framingham Study provided insights into the prevalence, incidence, prognosis, predisposing factors and determinants of CVD.
51.
go back to reference Hasegawa M. Fundamental research on human aortic pulse wave velocity. Jikei Med J. 1970;85:742–60. Hasegawa M. Fundamental research on human aortic pulse wave velocity. Jikei Med J. 1970;85:742–60.
56.
go back to reference Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D, et al. European network for non-invasive investigation of large arteries. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J. 2006;27:2588–2605. https://doi.org/10.1093/eurheartj/ehl254. Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D, et al. European network for non-invasive investigation of large arteries. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J. 2006;27:2588–2605. https://​doi.​org/​10.​1093/​eurheartj/​ehl254.
66.
go back to reference • Mitchell GF, Guo CY, Benjamin EJ, Larson MG, Keyes MJ, Vita JA, Vasan RS, Levy D. Cross-sectional correlates of increased aortic stiffness in the community: the Framingham Heart Study. Circulation. 2007;115(20):2628–36. https://doi.org/10.1161/CIRCULATIONAHA.106.667733. Findings from this study suggest that the prevalence of abnormal aortic stiffness increases steeply with advancing age, especially in the presence of obesity or diabetes. • Mitchell GF, Guo CY, Benjamin EJ, Larson MG, Keyes MJ, Vita JA, Vasan RS, Levy D. Cross-sectional correlates of increased aortic stiffness in the community: the Framingham Heart Study. Circulation. 2007;115(20):2628–36. https://​doi.​org/​10.​1161/​CIRCULATIONAHA.​106.​667733Findings from this study suggest that the prevalence of abnormal aortic stiffness increases steeply with advancing age, especially in the presence of obesity or diabetes.
68.
go back to reference Salomaa V, Riley W, Kark JD, Nardo C, Folsom AR. Non-insulin-dependent diabetes mellitus and fasting glucose and insulin concentrations are associated with arterial stiffness indexes. The ARIC Study. Atherosclerosis Risk in Communities Study. Circulation. 1995;91(5):1432–43. https://doi.org/10.1161/01.cir.91.5.1432. Salomaa V, Riley W, Kark JD, Nardo C, Folsom AR. Non-insulin-dependent diabetes mellitus and fasting glucose and insulin concentrations are associated with arterial stiffness indexes. The ARIC Study. Atherosclerosis Risk in Communities Study. Circulation. 1995;91(5):1432–43. https://​doi.​org/​10.​1161/​01.​cir.​91.​5.​1432.
75.
go back to reference • Franklin SS, Khan SA, Wong ND, Larson MG, Levy D. Is pulse pressure useful in predicting risk for coronary heart disease? The Framingham heart study Circulation. 1999;100(4):354–60. https://doi.org/10.1161/01.cir.100.4.354. Findings from this study suggest that higher pulse pressure is an important component of cardiovascular risk. • Franklin SS, Khan SA, Wong ND, Larson MG, Levy D. Is pulse pressure useful in predicting risk for coronary heart disease? The Framingham heart study Circulation. 1999;100(4):354–60. https://​doi.​org/​10.​1161/​01.​cir.​100.​4.​354. Findings from this study suggest that higher pulse pressure is an important component of cardiovascular risk.
76.
go back to reference • Benjamin EJ, Larson MG, Keyes MJ, Mitchell GF, Vasan RS, Keaney JF Jr, et al. Clinical correlates and heritability of flow-mediated dilation in the community: the Framingham Heart Study. Circulation. 2004;109(5):613–9. https://doi.org/10.1161/01.CIR.0000112565.60887.1E. Findings from this study suggest that increasing age, systolic blood pressure, and smoking are associated with lower flow-mediated dilation, whereas prior exercise and increasing heart rate were associated with higher flow-mediated dilation. • Benjamin EJ, Larson MG, Keyes MJ, Mitchell GF, Vasan RS, Keaney JF Jr, et al. Clinical correlates and heritability of flow-mediated dilation in the community: the Framingham Heart Study. Circulation. 2004;109(5):613–9. https://​doi.​org/​10.​1161/​01.​CIR.​0000112565.​60887.​1E. Findings from this study suggest that increasing age, systolic blood pressure, and smoking are associated with lower flow-mediated dilation, whereas prior exercise and increasing heart rate were associated with higher flow-mediated dilation.
77.
go back to reference • Mattace-Raso FU, van der Cammen TJ, Hofman A, van Popele NM, Bos ML, Schalekamp MA, et al. Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation. 2006;113(5):657–63. https://doi.org/10.1161/CIRCULATIONAHA.105.555235. This study concluded that aortic pulse wave velocity is an independent predictor of coronary heart disease and stroke in healthy individuals. • Mattace-Raso FU, van der Cammen TJ, Hofman A, van Popele NM, Bos ML, Schalekamp MA, et al. Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation. 2006;113(5):657–63. https://​doi.​org/​10.​1161/​CIRCULATIONAHA.​105.​555235. This study concluded that aortic pulse wave velocity is an independent predictor of coronary heart disease and stroke in healthy individuals.
82.
go back to reference •• Wang N, Guo Y, Li X, Dong Y, Liu Q, Wang G, et al. Association between cardio-ankle vascular index and masked uncontrolled hypertension in hypertensive patients: a cross-sectional study. J Atheroscler Thromb. 2022;2022(2):1–8. https://doi.org/10.1155/2022/3167518. Findings of this study support, for the first time, the novel notion that cardio-ankle vascular index, as an arterial stiffness parameter, is an independent risk factor for masked uncontrolled hypertension. •• Wang N, Guo Y, Li X, Dong Y, Liu Q, Wang G, et al. Association between cardio-ankle vascular index and masked uncontrolled hypertension in hypertensive patients: a cross-sectional study. J Atheroscler Thromb. 2022;2022(2):1–8. https://​doi.​org/​10.​1155/​2022/​3167518Findings of this study support, for the first time, the novel notion that cardio-ankle vascular index, as an arterial stiffness parameter, is an independent risk factor for masked uncontrolled hypertension.
90.
go back to reference •• Mavraganis G, Dimopoulou MA, Delialis D, Bampatsias D, Patras R, Sianis A, Maneta E, Stamatelopoulos K, Georgiopoulos G. Clinical implications of vascular dysfunction in acute and convalescent COVID-19: a systematic review. Eur J Clin Invest. 2022;52(11):e13859. https://doi.org/10.1111/eci.13859. Recent study, suggesting a detrimental effect of COVID‐19 on markers of endothelial function and arterial stiffness that could persist for months after the resolution of the infection. •• Mavraganis G, Dimopoulou MA, Delialis D, Bampatsias D, Patras R, Sianis A, Maneta E, Stamatelopoulos K, Georgiopoulos G. Clinical implications of vascular dysfunction in acute and convalescent COVID-19: a systematic review. Eur J Clin Invest. 2022;52(11):e13859. https://​doi.​org/​10.​1111/​eci.​13859. Recent study, suggesting a detrimental effect of COVID‐19 on markers of endothelial function and arterial stiffness that could persist for months after the resolution of the infection.
91.
go back to reference •• Schnaubelt S, Oppenauer J, Tihanyi D, et al. Arterial stiffness in acute COVID-19 and potential associations with clinical outcome. J Intern Med. 2021;290(2):437–43. https://doi.org/10.1111/joim.13275. Findings from this study suggest that COVID‐19 is related to enhanced pulse wave velocity, reflecting an increase in arterial stiffness. •• Schnaubelt S, Oppenauer J, Tihanyi D, et al. Arterial stiffness in acute COVID-19 and potential associations with clinical outcome. J Intern Med. 2021;290(2):437–43. https://​doi.​org/​10.​1111/​joim.​13275. Findings from this study suggest that COVID‐19 is related to enhanced pulse wave velocity, reflecting an increase in arterial stiffness.
92.
go back to reference •• Ratchford SM, Stickford JL, Province VM, et al. Vascular alterations among young adults with SARS‐CoV‐2. Am J Physiol Heart Circ Physiol. 2021;320(1):404‐410. https://doi.org/10.1152/ajpheart.00897. This study was the first to investigate the vascular implications of contracting SARS-CoV-2 among young, otherwise healthy adults. The main findings from this study are a strikingly lower vascular function and a higher arterial stiffness compared with healthy controls. This suggests significant vascular effects seen weeks after contracting SARS-CoV-2 in young adults. •• Ratchford SM, Stickford JL, Province VM, et al. Vascular alterations among young adults with SARS‐CoV‐2. Am J Physiol Heart Circ Physiol. 2021;320(1):404‐410. https://​doi.​org/​10.​1152/​ajpheart.​00897. This study was the first to investigate the vascular implications of contracting SARS-CoV-2 among young, otherwise healthy adults. The main findings from this study are a strikingly lower vascular function and a higher arterial stiffness compared with healthy controls. This suggests significant vascular effects seen weeks after contracting SARS-CoV-2 in young adults.
93.
go back to reference •• Jud P, Gressenberger P, Muster V, et al. Evaluation of endothelial dysfunction and inflammatory vasculopathy after SARS‐CoV‐2 infection‐a cross‐sectional study. Front Cardiovasc Med. 2021;8:750887. https://doi.org/10.3389/fcvm.2021.750887. Recent study suggesting that COVID-19 affects arterial stiffness, capillary morphology and selected parameters of arginine, kynurenine and homocysteine metabolism. •• Jud P, Gressenberger P, Muster V, et al. Evaluation of endothelial dysfunction and inflammatory vasculopathy after SARS‐CoV‐2 infection‐a cross‐sectional study. Front Cardiovasc Med. 2021;8:750887. https://​doi.​org/​10.​3389/​fcvm.​2021.​750887. Recent study suggesting that COVID-19 affects arterial stiffness, capillary morphology and selected parameters of arginine, kynurenine and homocysteine metabolism.
94.
go back to reference •• Szeghy RE, Province VM, Stute NL, et al. Carotid stiffness, intima‐media thickness and aortic augmentation index among adults with SARS‐CoV‐2. Exp Physiol. 2022;107(7):694‐707. https://doi.org/10.1113/ep089481. This study found that carotid stiffness and aortic augmentation index were greater in young adults who tested positive for SARS-CoV-2 compared with healthy young adults. These findings provide additional evidence for detrimental effects of SARS-CoV-2 on young adult vasculature, which might have implications for cardiovascular health. •• Szeghy RE, Province VM, Stute NL, et al. Carotid stiffness, intima‐media thickness and aortic augmentation index among adults with SARS‐CoV‐2. Exp Physiol. 2022;107(7):694‐707. https://​doi.​org/​10.​1113/​ep089481. This study found that carotid stiffness and aortic augmentation index were greater in young adults who tested positive for SARS-CoV-2 compared with healthy young adults. These findings provide additional evidence for detrimental effects of SARS-CoV-2 on young adult vasculature, which might have implications for cardiovascular health.
95.
go back to reference •• Zanoli L, Gaudio A, Mikhailidis DP, et al. Vascular dysfunction of COVID‐19 is partially reverted in the long‐term. Circ Res. 2022;130(9):1276‐1285. https://doi.org/10.1161/circresaha.121.320460. Recent study suggesting that COVID-19-related arterial stiffening involves several arterial tree portions and is partially resolved in the long-term. •• Zanoli L, Gaudio A, Mikhailidis DP, et al. Vascular dysfunction of COVID‐19 is partially reverted in the long‐term. Circ Res. 2022;130(9):1276‐1285. https://​doi.​org/​10.​1161/​circresaha.​121.​320460. Recent study suggesting that COVID-19-related arterial stiffening involves several arterial tree portions and is partially resolved in the long-term.
96.
go back to reference •• Evans PC, Rainger GE, Mason JC, Guzik TJ, Osto E, Stamataki Z, Neil D, Hoefer IE, Fragiadaki M, Waltenberger J, Weber C, Bochaton-Piallat ML, Bäck M. Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science. Cardiovasc Res. 2020;116(14):2177–2184. https://doi.org/10.1093/cvr/cvaa230. The Working Group on Atherosclerosis and Vascular Biology together with the Council of Basic Cardiovascular Science of the European Society of Cardiology provide a Position Statement on the importance of the endothelium in the underlying pathophysiology behind the clinical presentation in COVID-19 and identify key questions for future research to address. This position paper proposes that endothelial biomarkers and tests of function should be evaluated for their usefulness in the risk stratification of COVID-19 patients. •• Evans PC, Rainger GE, Mason JC, Guzik TJ, Osto E, Stamataki Z, Neil D, Hoefer IE, Fragiadaki M, Waltenberger J, Weber C, Bochaton-Piallat ML, Bäck M. Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science. Cardiovasc Res. 2020;116(14):2177–2184. https://​doi.​org/​10.​1093/​cvr/​cvaa230. The Working Group on Atherosclerosis and Vascular Biology together with the Council of Basic Cardiovascular Science of the European Society of Cardiology provide a Position Statement on the importance of the endothelium in the underlying pathophysiology behind the clinical presentation in COVID-19 and identify key questions for future research to address. This position paper proposes that endothelial biomarkers and tests of function should be evaluated for their usefulness in the risk stratification of COVID-19 patients.
98.
go back to reference Williams B, Lacy PS; CAFE and the ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) Investigators. Impact of heart rate on central aortic pressures and hemodynamics: analysis from the CAFE (Conduit Artery Function Evaluation) study: CAFE-Heart Rate. J Am Coll Cardiol. 2009;54(8):705–13. https://doi.org/10.1016/j.jacc.2009.02.088. Williams B, Lacy PS; CAFE and the ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) Investigators. Impact of heart rate on central aortic pressures and hemodynamics: analysis from the CAFE (Conduit Artery Function Evaluation) study: CAFE-Heart Rate. J Am Coll Cardiol. 2009;54(8):705–13. https://​doi.​org/​10.​1016/​j.​jacc.​2009.​02.​088.
100.
go back to reference Asmar RG, London GM, O'Rourke ME, Safar ME; REASON Project Coordinators and Investigators. Improvement in blood pressure, arterial stiffness and wave reflections with a very-low-dose perindopril/indapamide combination in hypertensive patient: a comparison with atenolol. Hypertension. 2001;38(4):922–6.https://doi.org/10.1161/hy1001.095774. Asmar RG, London GM, O'Rourke ME, Safar ME; REASON Project Coordinators and Investigators. Improvement in blood pressure, arterial stiffness and wave reflections with a very-low-dose perindopril/indapamide combination in hypertensive patient: a comparison with atenolol. Hypertension. 2001;38(4):922–6.https://​doi.​org/​10.​1161/​hy1001.​095774.
101.
go back to reference •• Cosentino F, Grant PJ, Aboyans V, Bailey CJ, Ceriello A, Delgado V, et al. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. Eur Heart J. 2020;41(2):255–323. https://doi.org/10.1093/eurheartj/ehz486. The emphasis in these guidelines is to provide information on the current state of the art in how to prevent and manage the effects of diabetes mellitus on the heart and vasculature. •• Cosentino F, Grant PJ, Aboyans V, Bailey CJ, Ceriello A, Delgado V, et al. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. Eur Heart J. 2020;41(2):255–323. https://​doi.​org/​10.​1093/​eurheartj/​ehz486. The emphasis in these guidelines is to provide information on the current state of the art in how to prevent and manage the effects of diabetes mellitus on the heart and vasculature.
103.
go back to reference •• Patoulias D, Papadopoulos C, Stavropoulos K, Zografou I, Doumas M, Karagiannis A. Prognostic value of arterial stiffness measurements in cardiovascular disease, diabetes, and its complications: The potential role of sodium-glucose co-transporter-2 inhibitors. The Journal of Clinical Hypertension. 2020;22(4):562–71. https://doi.org/10.1111/jch.13831. This paper summarised knowledge regarding the prognostic role of arterial stiffness in type 2 diabetes mellitus, along with the presentation of retrieved data on the potential role of sodium‐glucose co‐transporter‐2 inhibitors.CrossRefPubMedPubMedCentral •• Patoulias D, Papadopoulos C, Stavropoulos K, Zografou I, Doumas M, Karagiannis A. Prognostic value of arterial stiffness measurements in cardiovascular disease, diabetes, and its complications: The potential role of sodium-glucose co-transporter-2 inhibitors. The Journal of Clinical Hypertension. 2020;22(4):562–71. https://​doi.​org/​10.​1111/​jch.​13831This paper summarised knowledge regarding the prognostic role of arterial stiffness in type 2 diabetes mellitus, along with the presentation of retrieved data on the potential role of sodium‐glucose co‐transporter‐2 inhibitors.CrossRefPubMedPubMedCentral
115.
Metadata
Title
Arterial Stiffness and its Impact on Cardiovascular Health
Authors
Rachel Anne Xuereb
Caroline J. Magri
Robert G. Xuereb
Publication date
07-09-2023
Publisher
Springer US
Published in
Current Cardiology Reports / Issue 10/2023
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-023-01951-1

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