The apple core sign was originally described on barium enemas as an ab rupt, irregular, and segmental stenosis with “shouldered margins” in colonic wall [1‐3]. This sign represents a non-distensible narrowing of the intestinal lumen by a stenosing circumferential colorectal cancer that allows passage of only a small amount of contrast media. The appearance is similar to an apple core, that is, the remnant of a partially eaten apple (Fig. 1). The apple core sign is also known as “napkin ring sign” [1, 2].
WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.
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