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European Child & Adolescent Psychiatry
Published in: European Child & Adolescent Psychiatry 10/2019

01-10-2019 | Antidepressant Drugs | Original Contribution

Childhood methylphenidate adherence as a predictor of antidepressants use during adolescence

Authors: Nir Madjar, Dan Shlosberg, Maya Leventer-Roberts, Amichay Akriv, Adi Ghilai, Moshe Hoshen, Amir Krivoy, Gil Zalsman, Gal Shoval

Published in: European Child & Adolescent Psychiatry | Issue 10/2019

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Abstract

Methylphenidate (MPH) is a common and effective treatment for attention deficit hyperactivity disorder (ADHD), but little is known about the relationship between early childhood intake of MPH and onset of antidepressant treatment during adolescence. The study aimed to examine whether adherence to MPH during early childhood predicts the initiation of antidepressants during adolescence. This is a 12-year historical prospective nationwide cohort study of children enrolled in an integrated care system who were first prescribed MPH between the ages of 6 and 8 years (N = 6830). We tested for an association between their adherence to MPH during early childhood (as indicated by medication possession ratio from MPH onset through the age of twelve) and the likelihood of being prescribed any antidepressant during adolescence (age 13–18). As all country citizens are covered by mandatory health insurance, and full services are provided by one of the four integrated care systems, data regarding patients’ diagnoses, prescriptions, and medical purchases are well documented. Logistic regression analysis indicated that those with higher adherence to MPH had a 50% higher risk (95% CI 1.16–1.93) of receiving antidepressants during adolescence when controlling for other comorbid psychiatric conditions and parental use of antidepressants. In this large-scale longitudinal study, MPH adherence during early childhood emerged as a predictor for antidepressant treatment during adolescence, which may reflect increased emotional and behavioral dysregulation in this group. The highly adherent patients are at higher risk and should be clinically monitored more closely, particularly into adolescence.
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Metadata
Title
Childhood methylphenidate adherence as a predictor of antidepressants use during adolescence
Authors
Nir Madjar
Dan Shlosberg
Maya Leventer-Roberts
Amichay Akriv
Adi Ghilai
Moshe Hoshen
Amir Krivoy
Gil Zalsman
Gal Shoval
Publication date
01-10-2019
Publisher
Springer Berlin Heidelberg
Published in
European Child & Adolescent Psychiatry / Issue 10/2019
Print ISSN: 1018-8827
Electronic ISSN: 1435-165X
DOI
https://doi.org/10.1007/s00787-019-01301-z

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