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European Child & Adolescent Psychiatry
Published in: European Child & Adolescent Psychiatry 10/2013

Open Access 01-10-2013 | Original Contribution

An inventory of European data sources for the long-term safety evaluation of methylphenidate

Authors: Macey L. Murray, Suppachai Insuk, Tobias Banaschewski, Antje C. Neubert, Suzanne McCarthy, Jan K. Buitelaar, David Coghill, Ralf W. Dittmann, Kerstin Konrad, Pietro Panei, Eric Rosenthal, Edmund J. Sonuga-Barke, Ian C. K. Wong

Published in: European Child & Adolescent Psychiatry | Issue 10/2013

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Abstract

To compile an inventory of European healthcare databases with potential to study long-term effects of methylphenidate (MPH) in patients with attention deficit hyperactivity disorder (ADHD). Potential databases were identified through expert opinion, the website of the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance, and literature search. An online survey was conducted among database providers/coordinators to ascertain the databases’ appropriateness for inclusion into the inventory. It included questions about database characteristics, sample size, availability of information on drug exposure, clinical data and accessibility. Forty-two databases from 11 countries were identified and their coordinators invited to participate; responses were obtained for 22 (52.4 %) databases of which 15 record ADHD diagnoses. Eleven had sufficient data on ADHD diagnosis, drug exposure, and at least one type of outcome information (symptoms/clinical events, weight, height, blood pressure, heart rate) to assess MPH safety. These were Aarhus University Prescription Database, Danish National Birth Cohort (Denmark); German Health Interview and Examination Survey for Children and Adolescents; Health Search Database Thales, Italian ADHD Register, Lombardy Region ADHD Database (Italy); Avon Longitudinal Study of Parents and Children, General Practice Research Database, The Health Improvement Network, QResearch (UK) and IMS Disease Analyzer (UK, Germany, France). Of the 20 databases with no responses, information on seven from publications and/or websites was obtained; Pedianet and the Integrated Primary Care Information database were considered suitable. Many European healthcare databases can be used for multinational long-term safety studies of MPH. Methodological research is underway to investigate the feasibility of their pooling and analysis.
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Metadata
Title
An inventory of European data sources for the long-term safety evaluation of methylphenidate
Authors
Macey L. Murray
Suppachai Insuk
Tobias Banaschewski
Antje C. Neubert
Suzanne McCarthy
Jan K. Buitelaar
David Coghill
Ralf W. Dittmann
Kerstin Konrad
Pietro Panei
Eric Rosenthal
Edmund J. Sonuga-Barke
Ian C. K. Wong
Publication date
01-10-2013
Publisher
Springer Berlin Heidelberg
Published in
European Child & Adolescent Psychiatry / Issue 10/2013
Print ISSN: 1018-8827
Electronic ISSN: 1435-165X
DOI
https://doi.org/10.1007/s00787-013-0386-x

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