Published in:
Open Access 01-09-2019 | Antibiotic | Brief Report
Agreement Between Two Procalcitonin Assays in Hospitalized Children
Published in: Infectious Diseases and Therapy | Issue 3/2019
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Introduction
Agreement between available procalcitonin (PCT) assays is unclear. We sought to compare concordance between Roche and bioMérieux PCT assays using pediatric samples.
Methods
We evaluated 213 plasma samples from 208 children. We tested each sample on both the Roche and bioMérieux PCT platforms.
Results
At ranges < 2 μg/L, the Roche platform had a mean negative bias of 0.13 μg/L versus the bioMérieux platform. This bias resulted in PCT levels that crossed accepted cut points in 12.7% of patients.
Conclusions
PCT levels measured on either platform are similar, especially at PCT ranges used for antibiotic decision-making algorithms.
Funding
This work was supported by an investigator-initiated research agreement through bioMérieux and by the National Institute of Allergy and Infectious Diseases Childhood Infection Research Program (ChIRP), National Institute of Health and the National Center for Advancing Translational Sciences of the National Institute of Health.